ChemSpider 2D Image | CH5183284 | C20H16N6O

CH5183284

  • Molecular FormulaC20H16N6O
  • Average mass356.381 Da
  • Monoisotopic mass356.138550 Da
  • ChemSpider ID34450878

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

[5-Amino-1-(2-methyl-1H-benzimidazol-6-yl)-1H-pyrazol-4-yl](1H-indol-2-yl)methanon [German] [ACD/IUPAC Name]
[5-Amino-1-(2-methyl-1H-benzimidazol-6-yl)-1H-pyrazol-4-yl](1H-indol-2-yl)methanone [ACD/IUPAC Name]
[5-Amino-1-(2-méthyl-1H-benzimidazol-6-yl)-1H-pyrazol-4-yl](1H-indol-2-yl)méthanone [French] [ACD/IUPAC Name]
1265229-25-1 [RN]
CH5183284
DEBIO-1347
Methanone, [5-amino-1-(2-methyl-1H-benzimidazol-6-yl)-1H-pyrazol-4-yl]-1H-indol-2-yl- [ACD/Index Name]
NR9ZYH80Z8
(±)-naringenin
(5-Amino-1-(2-methyl-1H-benzo[d]imidazol-6-yl)-1H-pyrazol-4-yl)(1H-indol-2-yl)methanone
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  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Bio Activity:

      CH5183284 is a selective and orally available FGFR1/2/3 inhibitor. The IC50 values of CH5183284 on the enzyme activity of FGFR1/2/3/4 were 9.3, 7.6, 22, and 290 nM, respectively. ;IC50 value: 9.3, 7.6, 22, and 290 nM (FGFR1/2/3/4) [1];Target: FGFR;In vitro: The binding affinity (Kd) of CH5183284 for FGFR1, FGFR2, FGFR3, FGFR4, and KDR was 20, 20, 25, 740, and 960 nM, respectively (using the DiscoveRx panel). CH5183284 selectively inhibits FGFR1, FGFR2, and FGFR3 but does not inhibit kinase insert domain receptor (KDR) or other kinases. [1] CH5183284 shows antiproliferative activity against FGFR3-BAIAP2L1-positive cells only, including the bladder cancer cell line SW780, Rat-2_F3-B cells, and NIH-3T3 cells expressing FGFR3-BAIAP2L1, but not against NIH-3T3 cells expressing EML4-ALK (3T3_EML4-ALK) or HT1376 cells harboring WT FGFR. CH5183284/Debio 1347 induces apoptosis in SW780 and Rat-2_F3-B cells and suppresses FRS and ERK phosphorylation. [2];In vivo: CH5183284 shows significan MedChem Express HY-19957
      FGFR MedChem Express HY-19957
      Protein Tyrosine Kinase/RTK; MedChem Express HY-19957

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.5±0.1 g/cm3
Boiling Point: 775.5±55.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.7 mmHg at 25°C
Enthalpy of Vaporization: 112.9±3.0 kJ/mol
Flash Point: 422.8±31.5 °C
Index of Refraction: 1.804
Molar Refractivity: 100.7±0.5 cm3
#H bond acceptors: 7
#H bond donors: 4
#Freely Rotating Bonds: 3
#Rule of 5 Violations: 0
ACD/LogP: 2.40
ACD/LogD (pH 5.5): 2.00
ACD/BCF (pH 5.5): 16.69
ACD/KOC (pH 5.5): 215.95
ACD/LogD (pH 7.4): 2.29
ACD/BCF (pH 7.4): 32.13
ACD/KOC (pH 7.4): 415.70
Polar Surface Area: 105 Å2
Polarizability: 39.9±0.5 10-24cm3
Surface Tension: 66.9±7.0 dyne/cm
Molar Volume: 234.7±7.0 cm3

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