ChemSpider 2D Image | SGC707 | C16H18N4O2

SGC707

  • Molecular FormulaC16H18N4O2
  • Average mass298.340 Da
  • Monoisotopic mass298.142975 Da
  • ChemSpider ID34500443

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1-(6-Isochinolinyl)-3-[2-oxo-2-(1-pyrrolidinyl)ethyl]harnstoff [German] [ACD/IUPAC Name]
1-(6-Isoquinoléinyl)-3-[2-oxo-2-(1-pyrrolidinyl)éthyl]urée [French] [ACD/IUPAC Name]
1-(6-Isoquinolinyl)-3-[2-oxo-2-(1-pyrrolidinyl)ethyl]urea [ACD/IUPAC Name]
1-Isoquinolin-6-yl-3-(2-oxo-2-pyrrolidin-1-yl-ethyl)-urea
SGC707
Urea, N-6-isoquinolinyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]- [ACD/Index Name]
[1687736-54-4]
1-(isoquinolin-6-yl)-3-(2-oxo-2-(pyrrolidin-1-yl)ethyl)urea
1-(isoquinolin-6-yl)-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea
1687736-54-4 [RN]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 4693 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Safety:

      This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC 707 probe summary on the SGC website. Tocris Bioscience 5367
    • Bio Activity:

      Cell Cycle/DNA Damage MedChem Express HY-19715
      Cell Cycle/DNA Damage; MedChem Express HY-19715
      Enzymes Tocris Bioscience 5367
      HMTase MedChem Express HY-19715
      Potent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50 = 31 nM). Inhibits PRMT3-mediated methyltransferase activity in vitro. Displays >100-fold selectivity against 31 other methyltransferases and 250 other non-epigenetic targets. Tocris Bioscience 5367
      Potent allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50 = 31 nM). Inhibits PRMT3-mediated methyltransferase activity in vitro. Displays >100-fold selectivity against 31 other methyltransferases and 250 other non-epigenetic targets. Tocris Bioscience 5367
      Potent and selective allosteric inhibitor of PRMT3 Tocris Bioscience 5367
      Protein Arginine Methyltransferases Tocris Bioscience 5367
      SGC707 is a first-in-class PRMT3 chemical probe which is a potent, selective, and cell-active allosteric inhibitor of PRMT3 with IC50 of 31 nM.; IC50 value: 31 nM; Target: PRMT3; in vitro: SGC707 is the first PRMT3 chemical probe. MedChem Express HY-19715
      Transferases Tocris Bioscience 5367

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.3±0.1 g/cm3
Boiling Point: 538.5±46.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.4 mmHg at 25°C
Enthalpy of Vaporization: 81.6±3.0 kJ/mol
Flash Point: 279.5±29.0 °C
Index of Refraction: 1.677
Molar Refractivity: 84.6±0.3 cm3
#H bond acceptors: 6
#H bond donors: 2
#Freely Rotating Bonds: 3
#Rule of 5 Violations: 0
ACD/LogP: 0.94
ACD/LogD (pH 5.5): 0.75
ACD/BCF (pH 5.5): 1.69
ACD/KOC (pH 5.5): 37.15
ACD/LogD (pH 7.4): 1.21
ACD/BCF (pH 7.4): 4.89
ACD/KOC (pH 7.4): 107.70
Polar Surface Area: 74 Å2
Polarizability: 33.5±0.5 10-24cm3
Surface Tension: 69.3±3.0 dyne/cm
Molar Volume: 224.7±3.0 cm3

Click to predict properties on the Chemicalize site






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