ChemSpider 2D Image | LDN-214117 | C25H29N3O3

LDN-214117

  • Molecular FormulaC25H29N3O3
  • Average mass419.516 Da
  • Monoisotopic mass419.220886 Da
  • ChemSpider ID35033264

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1-(4-(6-Methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl)phenyl)piperazine
1-{4-[6-Methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl}piperazin [German] [ACD/IUPAC Name]
1-{4-[6-Methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl}piperazine [ACD/IUPAC Name]
1-{4-[6-Méthyl-5-(3,4,5-triméthoxyphényl)-3-pyridinyl]phényl}pipérazine [French] [ACD/IUPAC Name]
1-{4-[6-methyl-5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl}piperazine
1627503-67-6 [RN]
LDN-214117
Piperazine, 1-[4-[6-methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]- [ACD/Index Name]
[1627503-67-6] [RN]
1-​[4-​[6-​methyl-​5-​(3,​4,​5-​trimethoxyphenyl)​-​3-​pyridinyl]​phenyl]​-piperazine
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Safety:

      Sold for research purposes under exclusive agreement from The Brigham and Women's Hospital Inc. US patent 14/776,302 Tocris Bioscience 6152

    • Target Organs:

      TGF-beta/Smad inhibitor TargetMol T1944

    • Bio Activity:

      ALK MedChem Express HY-16712
      ALK2 TargetMol T1944
      BMP and Other Activin Receptors Tocris Bioscience 6152
      Enzyme-Linked Receptors Tocris Bioscience 6152
      LDN-214117 is a potent and selective ALK2 inhibitor with IC50 of 22 nM; MedChem Express http://www.medchemexpress.com/remodelin.html
      LDN-214117 is a potent and selective ALK2 inhibitor with IC50 of 22 nM; > 100 fold selectivity for ALK5; also inhibits BMP6(IC50=100 nM).; IC50 value: 22 nM(ALK2) [1]; Target: ALK2 inhibitor; LDN-214117 is a highly BMP selective compound, significantly biased toward ALK2 and its cognate ligands including BMP6 and also demonstrates a high degree of kinome selectivity and low; cytotoxicity. MedChem Express HY-16712
      LDN-214117 is a potent and selective ALK2 inhibitor with IC50 of 22 nM; > 100 fold selectivity for ALK5; also inhibits BMP6(IC50=100 nM).;IC50 value: 22 nM(ALK2) [1];Target: ALK2 inhibitorLDN-214117 is a highly BMP selective compound, significantly biased toward ALK2 and its cognate ligands including BMP6 and also demonstrates a high degree of kinome selectivity and lowcytotoxicity. LDN-214117 may be useful as highly selectiveprobes of BMP-mediated cellular physiology that may provide auseful complement to the dorsomorphin class of compounds. Furthermore, this class of BMP inhibitors offers a structurallydistinct template for the development of therapeutics for the;Treatment of BMP signaling-mediated diseases such as FOP. MedChem Express HY-16712
      Potent and selective ALK2 inhibitor Tocris Bioscience 6152
      Potent and selective inhibitor of type I bone morphogenic protein (BMP) receptor ALK2 (IC50 = 24 nM). Shows preference for ALK1 and ALK2 over ALK3 and 164-fold selectivity for BMP6 inhibition (IC50 = 100 nM) over TGF-beta1. Exhibits improved kinome selectivity over K 02288 (Cat.No. 4986) and low cytotoxicity. Tocris Bioscience 6152
      Protein Tyrosine Kinase/RTK MedChem Express HY-16712
      Protein Tyrosine Kinase/RTK; MedChem Express HY-16712
      Receptor Serine/Threonine Kinases (RSTKs) Tocris Bioscience 6152
      Tyrosine Kinase/Adaptors TargetMol T1944

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.1±0.1 g/cm3
Boiling Point: 567.9±50.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.6 mmHg at 25°C
Enthalpy of Vaporization: 85.2±3.0 kJ/mol
Flash Point: 297.3±30.1 °C
Index of Refraction: 1.573
Molar Refractivity: 121.9±0.3 cm3
#H bond acceptors: 6
#H bond donors: 1
#Freely Rotating Bonds: 6
#Rule of 5 Violations: 0
ACD/LogP: 3.27
ACD/LogD (pH 5.5): 0.34
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.67
ACD/LogD (pH 7.4): 2.08
ACD/BCF (pH 7.4): 11.42
ACD/KOC (pH 7.4): 90.24
Polar Surface Area: 56 Å2
Polarizability: 48.3±0.5 10-24cm3
Surface Tension: 42.2±3.0 dyne/cm
Molar Volume: 369.8±3.0 cm3

Click to predict properties on the Chemicalize site


Advertisement