ChemSpider 2D Image | MK-4827 (tosylate) | C26H28N4O4S

MK-4827 (tosylate)

  • Molecular FormulaC26H28N4O4S
  • Average mass492.590 Da
  • Monoisotopic mass492.183136 Da
  • ChemSpider ID35308189
  • defined stereocentres - 1 of 1 defined stereocentres


More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1038915-73-9 [RN]
2-{4-[(3S)-3-Piperidinyl]phenyl}-2H-indazole-7-carboxamide 4-methylbenzenesulfonate (1:1) [ACD/IUPAC Name]
2H-Indazole-7-carboxamide, 2-[4-[(3S)-3-piperidinyl]phenyl]-, 4-methylbenzenesulfonate (1:1) [ACD/Index Name]
4-Methylbenzolsulfonsäure --2-{4-[(3S)-3-piperidinyl]phenyl}-2H-indazol-7-carboxamid (1:1) [German] [ACD/IUPAC Name]
Acide 4-méthylbenzènesulfonique - 2-{4-[(3S)-3-pipéridinyl]phényl}-2H-indazole-7-carboxamide (1:1) [French] [ACD/IUPAC Name]
MK-4827 (tosylate)
Niraparib tosylate
(S)-2-(4-(Piperidin-3-yl)phenyl)-2H-indazole-7-carboxamide 4-methylbenzenesulfonate
1038915-73-9 (tosylate)
2-[4-(3S)-3-piperidinylphenyl]-2H-indazole-7-carboxamide, 4-methylbenzenesulfonate
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

75KE12AY9U [DBID]
UNII:75KE12AY9U [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Bio Activity:

      Cell Cycle/DNA Damage MedChem Express HY-10619B
      Cell Cycle/DNA Damage; MedChem Express HY-10619B
      MK-4827(Niraparib) tosylate is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; MedChem Express http://www.medchemexpress.com/gw3965.html
      MK-4827(Niraparib) tosylate is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP and Tank1.; IC50 value: 3.8 nM/2.1 nM( PARP1/2) [1]; Target: PARP1/2; in vitro: MK-4827 displays excellent PARP 1 and 2 inhibition with IC(50) = 3.8 and 2.1 nM, respectively, and in a whole cell assay, it inhibits PARP activity with EC(50) = 4 nM and inhibits proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC(50) in the 10-100 nM range [1]. MedChem Express HY-10619B
      MK-4827(Niraparib) tosylate is a selective inhibitor of PARP1/PARP2 with IC50 of 3.8 nM/2.1 nM; with great activity in cancer cells with mutant BRCA-1 and BRCA-2; >330-fold selective against PARP3, V-PARP and Tank1.;IC50 value: 3.8 nM/2.1 nM( PARP1/2) [1];Target: PARP1/2;In vitro: MK-4827 displays excellent PARP 1 and 2 inhibition with IC(50) = 3.8 and 2.1 nM, respectively, and in a whole cell assay, it inhibits PARP activity with EC(50) = 4 nM and inhibits proliferation of cancer cells with mutant BRCA-1 and BRCA-2 with CC(50) in the 10-100 nM range [1]. ;In vivo: MK-4827 is well tolerated in vivo and demonstrates efficacy as a single agent in a xenograft model of BRCA-1 deficient cancer [1]. In addition, MK-4827 strongly enhances the effect of radiation on a variety of human tumor xenografts, both p53 wild type and p53 mutant. The enhancement of radiation response is observed in clinically relevant radiation-dose fractionation schedules. The therapeutic window during which time MedChem Express HY-10619B
      PARP MedChem Express HY-10619B

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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