ChemSpider 2D Image | Ribociclib succinate | C27H36N8O5

Ribociclib succinate

  • Molecular FormulaC27H36N8O5
  • Average mass552.625 Da
  • Monoisotopic mass552.280884 Da
  • ChemSpider ID35308292

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1374639-75-4 [RN]
7H-Pyrrolo[2,3-d]pyrimidine-6-carboxamide, 7-cyclopentyl-N,N-dimethyl-2-[[5-(1-piperazinyl)-2-pyridinyl]amino]-, butanedioate (1:1) [ACD/Index Name]
Acide succinique - 7-cyclopentyl-N,N-diméthyl-2-{[5-(1-pipérazinyl)-2-pyridinyl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (1:1) [French] [ACD/IUPAC Name]
Bernsteinsäure --7-cyclopentyl-N,N-dimethyl-2-{[5-(1-piperazinyl)-2-pyridinyl]amino}-7H-pyrrolo[2,3-d]pyrimidin-6-carboxamid (1:1) [German] [ACD/IUPAC Name]
BG7HLX2919
LEE011-BBA
Ribociclib succinate [USAN]
Succinic acid - 7-cyclopentyl-N,N-dimethyl-2-{[5-(1-piperazinyl)-2-pyridinyl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (1:1) [ACD/IUPAC Name]
UNII:BG7HLX2919
1374639-75-4 (succinate)
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      CDK MedChem Express HY-15777B
      Cell Cycle/DNA Damage MedChem Express HY-15777B
      Cell Cycle/DNA Damage; MedChem Express HY-15777B
      LEE011 succinate is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. MedChem Express http://www.medchemexpress.com/tr-14035.html, HY-15777B
      LEE011 succinate is an orally available cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. ;IC50 Value: 307 ? 68 nM (neuroblastoma-derived cell lines) [1];Target: CDK4;CDK6;In vitro: CDK4/6 inhibitor LEE011 specifically inhibits CDK4 and 6, thereby inhibiting retinoblastoma (Rb) protein phosphorylation. Inhibition of Rb phosphorylation prevents CDK-mediated G1-S phase transition, thereby arresting the cell cycle in the G1 phase, suppressing DNA synthesis and inhibiting cancer cell growth. Overexpression of CDK4/6, as seen in certain types of cancer, causes cell cycle deregulation.Treatment with LEE011 significantly reduced proliferation in 12 of 17 human neuroblastoma-derived cell lines by inducing cytostasis at nanomolar concentrations (mean IC50 = 307 ? 68 nmol/L in sensitive lines). LEE011 caused cell-cycle arrest and cellular senescence that was attributed to dose-dependent decreases in MedChem Express HY-15777B

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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