Found 1 result

Search term: 475207-59-1 (Found by approved synonym)

ChemSpider 2D Image | Sorafenib tosylate | C28H24ClF3N4O6S

Sorafenib tosylate

  • Molecular FormulaC28H24ClF3N4O6S
  • Average mass637.027 Da
  • Monoisotopic mass636.105713 Da
  • ChemSpider ID359744

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

2-Pyridinecarboxamide, 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-, 4-methylbenzenesulfonate (1:1) [ACD/Index Name]
4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methyl-2-pyridinecarboxamide 4-methylbenzenesulfonate (1:1) [ACD/IUPAC Name]
4-[4-({[4-Chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridine-2-carboxamide 4-methylbenzenesulfonate (1:1)
475207-59-1 [RN]
4-Methylbenzolsulfonsäure --4-[4-({[4-chlor-3-(trifluormethyl)phenyl]carbamoyl}amino)phenoxy]-N-methyl-2-pyridincarboxamid (1:1) [German] [ACD/IUPAC Name]
4-Methylbenzolsulfonsäure--4-[4-({[4-chlor-3-(trifluormethyl)phenyl]carbamoyl}amino)phenoxy]-N-methylpyridin-2-carboxamid(1:1)
5T62Q3B36J
Acide 4-méthylbenzènesulfonique - 4-[4-({[4-chloro-3-(trifluorométhyl)phényl]carbamoyl}amino)phénoxy]-N-méthyl-2-pyridinecarboxamide (1:1) [French] [ACD/IUPAC Name]
acide 4-méthylbenzènesulfonique - 4-[4-({[4-chloro-3-(trifluorométhyl)phényl]carbamoyl}amino)phénoxy]-N-méthylpyridine-2-carboxamide (1:1)
Nexavar [Trade name]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

BAY 54-9085 [DBID]
BAY 43-9006 [DBID]
NSC724772 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Safety:

      5 Axon Medchem 1397
      GHS07 Biosynth Q-201730
      H303;H313;H317;H333;H334;H335;H373 Axon Medchem 1397
      H315; H319; H335 Biosynth Q-201730
      no pictogram Axon Medchem 1397
      P101;P102;P103;P260;P262;P263;P264;P270;P280;P304;P312;P340 Axon Medchem 1397
      P261; P280; P302+P352; P304+P340; P305+P351+P338; P312 Biosynth Q-201730
      Warning Biosynth Q-201730
      Warning Axon Medchem 1397
    • Target Organs:

      PDGFR inhibitor; Raf inhibitor; FLT3 inhibitor, FGFR inhibitor, RET inhibitor; Mast/stem cell GFR Kit TargetMol T0093
    • Bio Activity:

      MAPK MedChem Express HY-10201A
      MAPK ; MedChem Express HY-10201A
      PDGFR??, B-raf, RAF-1, FLT3, Mast/stem cell GFR, FGFR1, ret;Mast/stem cell GFR Kit TargetMol T0093
      Raf MedChem Express HY-10201A
      Sorafenib tosylate (BAY 43-9006) is a potent inhibitor of Raf-1 with IC50 values of 6 nM, 22 nM and 90 nM for Raf-1, B-Raf, and VEGFR2 respectively, BAY 43-9006 suppresses both wild-type and V599E mut ant BRAF activity in vitro. MedChem Express
      Sorafenib tosylate (BAY 43-9006) is a potent inhibitor of Raf-1 with IC50 values of 6 nM, 22 nM and 90 nM for Raf-1, B-Raf, and VEGFR2 respectively, BAY 43-9006 suppresses both wild-type and V599E mutant BRAF activity in vitro.; IC50 Value: 6 nM (Raf-1); 22 nM (B-Raf); 90 nM (VEGFR2) [1]; Target: Raf-1; Sorafenib is a drug approved for the treatment of primary kidney cancer (advanced renal cell carcinoma) and advanced primary liver cancer (hepatocellular carcinoma). MedChem Express HY-10201A
      Tyrosine Kinase/Adaptors; MAPK Signaling TargetMol T0093

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

No predicted properties have been calculated for this compound.

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