ChemSpider 2D Image | Manidipine | C35H38N4O6


  • Molecular FormulaC35H38N4O6
  • Average mass610.699 Da
  • Monoisotopic mass610.279114 Da
  • ChemSpider ID3868

More details:

Featured data source

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl Methyl Ester
2,6-Diméthyl-4-(3-nitrophényl)-1,4-dihydro-3,5-pyridinedicarboxylate de 2-[4-(diphénylméthyl)-1-pipérazinyl]éthyle et de méthyle [French] [ACD/IUPAC Name]
2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate [ACD/IUPAC Name]
2-[4-(Diphenylmethyl)-1-piperazinyl]ethylmethyl (±)-1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinecarboxylate
2-[4-(Diphenylmethyl)-1-piperazinyl]ethyl-methyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridindicarboxylat [German] [ACD/IUPAC Name]
2-[4-(diphenylmethyl)piperazin-1-yl]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester [ACD/Index Name]
89226-50-6 [RN]
Manidipine [Wiki] [INN]

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

6300 [DBID]
6O4754US88 [DBID]
UNII:6O4754US88 [DBID]
BR-72917 [DBID]
CHEMBL1085699 [DBID]
QA-2961 [DBID]
R803FSR459 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Safety:

      C08CA11 Wikidata Q921133
      IRRITANT Matrix Scientific 076068
    • Bio Activity:

      Calcium Channel MedChem Express HY-B0419
      Manidipine is a calcium channel blocker that is used clinically as an antihypertensive. MedChem Express, HY-B0419
      Manidipine is a calcium channel blocker that is used clinically as an antihypertensive. ;Target: Calcium ChannelManidipine is a dihydropyridine calcium antagonist, which causes systemic vasodilation by inhibiting the voltage-dependent calcium inward currents in smooth muscle cells. Manidipine was well tolerated in clinical trials, with most adverse effects related to vasodilation [1]. Manidipine is a lipophilic, third-generation dihydropyridine calcium channel antagonist with a high degree of selectivity for the vasculature, thereby inducing marked peripheral vasodilation with negligible cardiodepression. manidipine represents a first-line treatment option for patients with essential mild-to-moderate hypertension [2]. Manidipine has neutral effects on glucose and lipid metabolism and is generally well tolerated. Manidipine thus represents a first-line option for lowering BP in patients with mild-to-moderate hypertension [3]. MedChem Express HY-B0419
      Membrane Tranporter/Ion Channel MedChem Express HY-B0419
      Membrane Tranporter/Ion Channel; MedChem Express HY-B0419

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.2±0.1 g/cm3
Boiling Point: 722.0±60.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.3 mmHg at 25°C
Enthalpy of Vaporization: 105.5±3.0 kJ/mol
Flash Point: 390.4±32.9 °C
Index of Refraction: 1.601
Molar Refractivity: 169.7±0.3 cm3
#H bond acceptors: 10
#H bond donors: 1
#Freely Rotating Bonds: 12
#Rule of 5 Violations: 3
ACD/LogP: 5.46
ACD/LogD (pH 5.5): 4.62
ACD/BCF (pH 5.5): 1152.95
ACD/KOC (pH 5.5): 3000.89
ACD/LogD (pH 7.4): 5.48
ACD/BCF (pH 7.4): 8432.27
ACD/KOC (pH 7.4): 21947.37
Polar Surface Area: 117 Å2
Polarizability: 67.3±0.5 10-24cm3
Surface Tension: 50.2±3.0 dyne/cm
Molar Volume: 495.5±3.0 cm3

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