ChemSpider 2D Image | 1-Amino-5-phosphono-1-indanecarboxylic acid | C10H12NO5P

1-Amino-5-phosphono-1-indanecarboxylic acid

  • Molecular FormulaC10H12NO5P
  • Average mass257.180 Da
  • Monoisotopic mass257.045319 Da
  • ChemSpider ID3881975

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

170847-18-4 [RN]
1-Amino-2,3-dihydro-5-phosphono-1H-indene-1-carboxylic acid
1-Amino-5-phosphono-1-indancarbonsäure [German] [ACD/IUPAC Name]
1-Amino-5-phosphono-1-indanecarboxylic acid [ACD/IUPAC Name]
1-Amino-5-phosphonoindane-1-carboxylic acid
1H-Indene-1-carboxylic acid, 1-amino-2,3-dihydro-5-phosphono- [ACD/Index Name]
Acide 1-amino-5-phosphono-1-indanecarboxylique [French] [ACD/IUPAC Name]
(RS)-1-Amino-5-phosphonoindan-1-carboxylic acid
(RS)-APICA
[170847-18-4] [RN]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 4693 [DBID]
NSC 231634 | [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Bio Activity:

      7-TM Receptors Tocris Bioscience 1073
      Glutamate (Metabotropic) Group II Receptors Tocris Bioscience 1073
      Glutamate (Metabotropic) Receptors Tocris Bioscience 1073
      Rigidified analog of MPPG (Cat. No. 0853); selective group II metabotropic glutamate receptor antagonist (IC50 = 30 ?M) with no significant effect on group I and III mGlu receptors at concentrations u p to 1 mM. Increases extracellular glutamate concentrations and possesses unusual inverse agonist-like action. Tocris Bioscience 1073
      Rigidified analog of MPPG (Cat. No. 0853); selective group II metabotropic glutamate receptor antagonist (IC50 = 30 ?M) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Increases extracellular glutamate concentrations and possesses unusual inverse agonist-like action. Tocris Bioscience 1073
      Rigidified analog of MPPG (Cat. No. 0853); selective group II metabotropic glutamate receptor antagonist (IC50 = 30 muM) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Increases extracellular glutamate concentrations and possesses unusual inverse agonist-like action. Tocris Bioscience 1073
      Selective group II antagonist Tocris Bioscience 1073

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.6±0.1 g/cm3
Boiling Point: 559.9±60.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.6 mmHg at 25°C
Enthalpy of Vaporization: 88.6±3.0 kJ/mol
Flash Point: 292.4±32.9 °C
Index of Refraction: 1.671
Molar Refractivity: 58.3±0.4 cm3
#H bond acceptors: 6
#H bond donors: 5
#Freely Rotating Bonds: 2
#Rule of 5 Violations: 1
ACD/LogP: -0.89
ACD/LogD (pH 5.5): -4.52
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): -4.80
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 1.00
Polar Surface Area: 131 Å2
Polarizability: 23.1±0.5 10-24cm3
Surface Tension: 93.2±5.0 dyne/cm
Molar Volume: 155.9±5.0 cm3

Predicted data is generated using the US Environmental Protection Agency�s EPISuite™

                        
 Log Octanol-Water Partition Coef (SRC):
    Log Kow (KOWWIN v1.67 estimate) =  -2.36

 Boiling Pt, Melting Pt, Vapor Pressure Estimations (MPBPWIN v1.42):
    Boiling Pt (deg C):  480.00  (Adapted Stein & Brown method)
    Melting Pt (deg C):  304.03  (Mean or Weighted MP)
    VP(mm Hg,25 deg C):  1.95E-013  (Modified Grain method)
    Subcooled liquid VP: 2.58E-010 mm Hg (25 deg C, Mod-Grain method)

 Water Solubility Estimate from Log Kow (WSKOW v1.41):
    Water Solubility at 25 deg C (mg/L):  1.9e+004
       log Kow used: -2.36 (estimated)
       no-melting pt equation used

 Water Sol Estimate from Fragments:
    Wat Sol (v1.01 est) =  1.2572e+005 mg/L

 ECOSAR Class Program (ECOSAR v0.99h):
    Class(es) found:
       Aliphatic Amines-acid
       Benzyl Amines-acid

 Henrys Law Constant (25 deg C) [HENRYWIN v3.10]:
   Bond Method :   3.39E-021  atm-m3/mole
   Group Method:   Incomplete
 Henrys LC [VP/WSol estimate using EPI values]:  3.473E-018 atm-m3/mole

 Log Octanol-Air Partition Coefficient (25 deg C) [KOAWIN v1.10]:
  Log Kow used:  -2.36  (KowWin est)
  Log Kaw used:  -18.858  (HenryWin est)
      Log Koa (KOAWIN v1.10 estimate):  16.498
      Log Koa (experimental database):  None

 Probability of Rapid Biodegradation (BIOWIN v4.10):
   Biowin1 (Linear Model)         :   0.7224
   Biowin2 (Non-Linear Model)     :   0.4909
 Expert Survey Biodegradation Results:
   Biowin3 (Ultimate Survey Model):   2.7329  (weeks-months)
   Biowin4 (Primary Survey Model) :   3.6836  (days-weeks  )
 MITI Biodegradation Probability:
   Biowin5 (MITI Linear Model)    :   0.2178
   Biowin6 (MITI Non-Linear Model):   0.0400
 Anaerobic Biodegradation Probability:
   Biowin7 (Anaerobic Linear Model):  0.3378
 Ready Biodegradability Prediction:   NO

Hydrocarbon Biodegradation (BioHCwin v1.01):
    Structure incompatible with current estimation method!

 Sorption to aerosols (25 Dec C)[AEROWIN v1.00]:
  Vapor pressure (liquid/subcooled):  3.44E-008 Pa (2.58E-010 mm Hg)
  Log Koa (Koawin est  ): 16.498
   Kp (particle/gas partition coef. (m3/ug)):
       Mackay model           :  87.2 
       Octanol/air (Koa) model:  7.73E+003 
   Fraction sorbed to airborne particulates (phi):
       Junge-Pankow model     :  1 
       Mackay model           :  1 
       Octanol/air (Koa) model:  1 

 Atmospheric Oxidation (25 deg C) [AopWin v1.92]:
   Hydroxyl Radicals Reaction:
      OVERALL OH Rate Constant =  29.2521 E-12 cm3/molecule-sec
      Half-Life =     0.366 Days (12-hr day; 1.5E6 OH/cm3)
      Half-Life =     4.388 Hrs
   Ozone Reaction:
      No Ozone Reaction Estimation
   Fraction sorbed to airborne particulates (phi): 1 (Junge,Mackay)
    Note: the sorbed fraction may be resistant to atmospheric oxidation

 Soil Adsorption Coefficient (PCKOCWIN v1.66):
      Koc    :  10
      Log Koc:  1.000 

 Aqueous Base/Acid-Catalyzed Hydrolysis (25 deg C) [HYDROWIN v1.67]:
    Rate constants can NOT be estimated for this structure!

 Bioaccumulation Estimates from Log Kow (BCFWIN v2.17):
   Log BCF from regression-based method = 0.500 (BCF = 3.162)
       log Kow used: -2.36 (estimated)

 Volatilization from Water:
    Henry LC:  3.39E-021 atm-m3/mole  (estimated by Bond SAR Method)
    Half-Life from Model River:  2.77E+017  hours   (1.154E+016 days)
    Half-Life from Model Lake : 3.021E+018  hours   (1.259E+017 days)

 Removal In Wastewater Treatment:
    Total removal:               1.85  percent
    Total biodegradation:        0.09  percent
    Total sludge adsorption:     1.75  percent
    Total to Air:                0.00  percent
      (using 10000 hr Bio P,A,S)

 Level III Fugacity Model:
           Mass Amount    Half-Life    Emissions
            (percent)        (hr)       (kg/hr)
   Air       3.82e-010       8.77         1000       
   Water     46.5            900          1000       
   Soil      53.5            1.8e+003     1000       
   Sediment  0.0892          8.1e+003     0          
     Persistence Time: 973 hr




                    

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