ChemSpider 2D Image | met-enkephalin | C27H35N5O7S

met-enkephalin

  • Molecular FormulaC27H35N5O7S
  • Average mass573.661 Da
  • Monoisotopic mass573.225708 Da
  • ChemSpider ID391597
  • defined stereocentres - 3 of 3 defined stereocentres


More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

[5-Methionine]Enkephalin
[Met]enkephalin
261-335-8 [EINECS]
H-Tyr-Gly-Gly-Phe-Met-OH
L-Methionine, L-tyrosylglycylglycyl-L-phenylalanyl- [ACD/Index Name]
L-Tyrosylglycylglycyl-L-phenylalanyl-L-methionin [German] [ACD/IUPAC Name]
L-Tyrosylglycylglycyl-L-phenylalanyl-L-methionine [ACD/IUPAC Name]
L-Tyrosylglycylglycyl-L-phénylalanyl-L-méthionine [French] [ACD/IUPAC Name]
metencefalina [Spanish] [INN]
métenkefaline [French] [INN]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

AIDS000187 [DBID]
AIDS-000187 [DBID]
C11684 [DBID]
M6638_SIGMA [DBID]
  • Miscellaneous
    • Bio Activity:

      GPCR/G protein MedChem Express HY-P0073
      GPCR/G protein; Neuronal Signaling; MedChem Express HY-P0073
      Opioid Receptor MedChem Express HY-P0073
      Tyr-Gly-Gly-Phe-Met-OH (Methionine enkephalin) is synthetic opioid peptides.; Target: Opioid Receptor; Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems. MedChem Express HY-P0073
      Tyr-Gly-Gly-Phe-Met-OH (Methionine enkephalin) is synthetic opioid peptides.;Target: Opioid ReceptorMethionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems. MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells. Clinical trial studies in cancer patients have shown that MENK activates immune cells directly and by inhibiting regulatory T-cells (Tregs). MENK may also change the tumor microenvironment by binding to opioid receptor on or in cancer cells. All of these mechanisms of action have biologic significance and potential for use in cancer immunotherapy. Furthermore, they reveal a relationship between the endocrine and immune systems. Due to the apparent role of MENK in cancer therapy we reviewed herein, the research undertaken with MENK in recent years; which has advanced our understanding of the role MENK has in cancer pro MedChem Express HY-P0073

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.3±0.1 g/cm3
Boiling Point: 1052.9±65.0 °C at 760 mmHg
Vapour Pressure: 0.0±0.3 mmHg at 25°C
Enthalpy of Vaporization: 161.5±3.0 kJ/mol
Flash Point: 590.6±34.3 °C
Index of Refraction: 1.609
Molar Refractivity: 149.9±0.3 cm3
#H bond acceptors: 12
#H bond donors: 8
#Freely Rotating Bonds: 16
#Rule of 5 Violations: 3
ACD/LogP: 1.54
ACD/LogD (pH 5.5): -1.18
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): -1.54
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 1.00
Polar Surface Area: 225 Å2
Polarizability: 59.4±0.5 10-24cm3
Surface Tension: 61.7±3.0 dyne/cm
Molar Volume: 433.1±3.0 cm3

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