ChemSpider 2D Image | 11-Dehydrothromboxane B2 | C20H32O6

11-Dehydrothromboxane B2

  • Molecular FormulaC20H32O6
  • Average mass368.465 Da
  • Monoisotopic mass368.219879 Da
  • ChemSpider ID4444414
  • Double-bond stereo - Double-bond stereo

    defined stereocentres - 4 of 4 defined stereocentres


More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(5Z)-7-{(2R,3S,4S)-4-Hydroxy-2-[(1E,3S)-3-hydroxy-1-octen-1-yl]-6-oxotetrahydro-2H-pyran-3-yl}-5-heptenoic acid [ACD/IUPAC Name]
(5Z)-7-{(2R,3S,4S)-4-Hydroxy-2-[(1E,3S)-3-hydroxy-1-octen-1-yl]-6-oxotetrahydro-2H-pyran-3-yl}-5-heptensäure [German] [ACD/IUPAC Name]
11-dehydro Thromboxane B2
11-dehydro-thromboxane B2
11-Dehydrothromboxane B2 [Wiki]
11-Dehydro-thromboxane B2
1-dehydro-TXB2
5-Heptenoic acid, 7-((2R,3S,4S)-tetrahydro-4-hydroxy-2-((1E,3S)-3-hydroxy-1-octenyl)-6-oxo-2H-pyran-3-yl)-, (5Z)-
Acide (5Z)-7-{(2R,3S,4S)-4-hydroxy-2-[(1E,3S)-3-hydroxy-1-octén-1-yl]-6-oxotétrahydro-2H-pyran-3-yl}-5-hepténoïque [French] [ACD/IUPAC Name]
Thromboxa-5,13-dien-1-oic acid, 9,15-dihydroxy-11-oxo-, (5Z,9α,13E,15S)-
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

C05964 [DBID]
CHEBI:28667 [DBID]
LMFA03030004 [DBID]
  • Miscellaneous
    • Chemical Class:

      A thromboxane obtained by formal oxidation of the hemiacetal hydroxy function of thromboxane B<smallsub>2</smallsub>. ChEBI CHEBI:28667

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.2±0.1 g/cm3
Boiling Point: 588.5±50.0 °C at 760 mmHg
Vapour Pressure: 0.0±3.7 mmHg at 25°C
Enthalpy of Vaporization: 100.8±6.0 kJ/mol
Flash Point: 202.9±23.6 °C
Index of Refraction: 1.552
Molar Refractivity: 100.9±0.3 cm3
#H bond acceptors: 6
#H bond donors: 3
#Freely Rotating Bonds: 12
#Rule of 5 Violations: 0
ACD/LogP: 1.96
ACD/LogD (pH 5.5): 1.48
ACD/BCF (pH 5.5): 4.98
ACD/KOC (pH 5.5): 64.33
ACD/LogD (pH 7.4): -0.32
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 1.03
Polar Surface Area: 104 Å2
Polarizability: 40.0±0.5 10-24cm3
Surface Tension: 52.7±3.0 dyne/cm
Molar Volume: 315.6±3.0 cm3

Predicted data is generated using the US Environmental Protection Agency’s EPISuite™

                        
 Log Octanol-Water Partition Coef (SRC):
    Log Kow (KOWWIN v1.67 estimate) =  3.07

 Boiling Pt, Melting Pt, Vapor Pressure Estimations (MPBPWIN v1.42):
    Boiling Pt (deg C):  552.16  (Adapted Stein & Brown method)
    Melting Pt (deg C):  236.47  (Mean or Weighted MP)
    VP(mm Hg,25 deg C):  6.72E-015  (Modified Grain method)
    Subcooled liquid VP: 1.29E-012 mm Hg (25 deg C, Mod-Grain method)

 Water Solubility Estimate from Log Kow (WSKOW v1.41):
    Water Solubility at 25 deg C (mg/L):  28.52
       log Kow used: 3.07 (estimated)
       no-melting pt equation used

 Water Sol Estimate from Fragments:
    Wat Sol (v1.01 est) =  179.42 mg/L

 ECOSAR Class Program (ECOSAR v0.99h):
    Class(es) found:
       Esters-acid
       Surfactants-anionic-acid
       Vinyl/Allyl Alcohols-acid

 Henrys Law Constant (25 deg C) [HENRYWIN v3.10]:
   Bond Method :   5.53E-014  atm-m3/mole
   Group Method:   Incomplete
 Henrys LC [VP/WSol estimate using EPI values]:  1.142E-016 atm-m3/mole

 Log Octanol-Air Partition Coefficient (25 deg C) [KOAWIN v1.10]:
  Log Kow used:  3.07  (KowWin est)
  Log Kaw used:  -11.646  (HenryWin est)
      Log Koa (KOAWIN v1.10 estimate):  14.716
      Log Koa (experimental database):  None

 Probability of Rapid Biodegradation (BIOWIN v4.10):
   Biowin1 (Linear Model)         :   1.2449
   Biowin2 (Non-Linear Model)     :   0.9986
 Expert Survey Biodegradation Results:
   Biowin3 (Ultimate Survey Model):   3.5080  (days-weeks  )
   Biowin4 (Primary Survey Model) :   4.4586  (hours-days  )
 MITI Biodegradation Probability:
   Biowin5 (MITI Linear Model)    :   0.8900
   Biowin6 (MITI Non-Linear Model):   0.6889
 Anaerobic Biodegradation Probability:
   Biowin7 (Anaerobic Linear Model):  0.8092
 Ready Biodegradability Prediction:   YES

Hydrocarbon Biodegradation (BioHCwin v1.01):
    Structure incompatible with current estimation method!

 Sorption to aerosols (25 Dec C)[AEROWIN v1.00]:
  Vapor pressure (liquid/subcooled):  1.72E-010 Pa (1.29E-012 mm Hg)
  Log Koa (Koawin est  ): 14.716
   Kp (particle/gas partition coef. (m3/ug)):
       Mackay model           :  1.74E+004 
       Octanol/air (Koa) model:  128 
   Fraction sorbed to airborne particulates (phi):
       Junge-Pankow model     :  1 
       Mackay model           :  1 
       Octanol/air (Koa) model:  1 

 Atmospheric Oxidation (25 deg C) [AopWin v1.92]:
   Hydroxyl Radicals Reaction:
      OVERALL OH Rate Constant = 150.1360 E-12 cm3/molecule-sec [Cis-isomer]
      OVERALL OH Rate Constant = 165.3360 E-12 cm3/molecule-sec [Trans-isomer]
      Half-Life =    0.855 Hrs (12-hr day; 1.5E6 OH/cm3) [Cis-isomer]
      Half-Life =    0.776 Hrs (12-hr day; 1.5E6 OH/cm3) [Trans-isomer]
   Ozone Reaction:
      OVERALL Ozone Rate Constant =    26.000000 E-17 cm3/molecule-sec [Cis-]
      OVERALL Ozone Rate Constant =    40.000000 E-17 cm3/molecule-sec [Trans-]
      Half-Life =     1.058 Hrs (at 7E11 mol/cm3) [Cis-isomer]
      Half-Life =     0.688 Hrs (at 7E11 mol/cm3) [Trans-isomer]
   Reaction With Nitrate Radicals May Be Important!
   Fraction sorbed to airborne particulates (phi): 1 (Junge,Mackay)
    Note: the sorbed fraction may be resistant to atmospheric oxidation

 Soil Adsorption Coefficient (PCKOCWIN v1.66):
      Koc    :  13.69
      Log Koc:  1.136 

 Aqueous Base/Acid-Catalyzed Hydrolysis (25 deg C) [HYDROWIN v1.67]:
    Rate constants can NOT be estimated for this structure!

 Bioaccumulation Estimates from Log Kow (BCFWIN v2.17):
   Log BCF from regression-based method = 0.500 (BCF = 3.162)
       log Kow used: 3.07 (estimated)

 Volatilization from Water:
    Henry LC:  5.53E-014 atm-m3/mole  (estimated by Bond SAR Method)
    Half-Life from Model River: 2.032E+010  hours   (8.468E+008 days)
    Half-Life from Model Lake : 2.217E+011  hours   (9.238E+009 days)

 Removal In Wastewater Treatment:
    Total removal:               6.33  percent
    Total biodegradation:        0.13  percent
    Total sludge adsorption:     6.20  percent
    Total to Air:                0.00  percent
      (using 10000 hr Bio P,A,S)

 Level III Fugacity Model:
           Mass Amount    Half-Life    Emissions
            (percent)        (hr)       (kg/hr)
   Air       0.101           0.654        1000       
   Water     27.2            208          1000       
   Soil      72.3            416          1000       
   Sediment  0.385           1.87e+003    0          
     Persistence Time: 288 hr




                    

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