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Polythiazide

Molecular FormulaC₁₁H₁₃ClF₃N₃O₄S₃
Average mass439.882 Da
Monoisotopic mass438.970886 Da
ChemSpider ID4704

More details:

Featured data source

Names and Synonyms
Database ID(s)

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1,1-Dioxyde de 6-chloro-2-méthyl-3-{[(2,2,2-trifluoroéthyl)sulfanyl]méthyl}-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide [French] [ACD/IUPAC Name]

206-468-4 [EINECS]

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-2-methyl-3-(((2,2,2-trifluoroethyl)thio)methyl)-, 1,1-dioxide

2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoroethyl)thio]methyl]-, 1,1-dioxide [ACD/Index Name]

346-18-9 [RN]

6-Chlor-2-methyl-3-{[(2,2,2-trifluorethyl)sulfanyl]methyl}-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-sulfonamid-1,1-dioxid [German] [ACD/IUPAC Name]

6-CHLORO-2-METHYL-3-[[(2,2,2-TRIFLUOROETHYL)SULFANYL]METHYL]-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE-7-SULFONAMIDE 1,1-DIOXIDE

6-Chloro-2-methyl-3-{[(2,2,2-trifluoroethyl)sulfanyl]methyl}-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide [ACD/IUPAC Name]

6-chloro-2-méthyl-3-{[(2,2,2-trifluoroéthyl)sulfanyl]méthyl}-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxyde

6-chloro-2-methyl-3-{[(2,2,2-trifluoroethyl)thio]methyl}-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

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Drenusil [Trade name]

MFCD00072071

Nephril [Trade name]

politiazida [Spanish] [INN]

polythiazide [French] [INN]

Polythiazide [BAN] [INN] [JAN] [USAN] [Wiki]

polythiazidum [Latin] [INN]

Renese [Trade name]

политиазид [Russian] [INN]

بوليثيازيد [Arabic] [INN]

泊利噻嗪 [Chinese] [INN]

⁶,2,4-benzothiadiazine-7-sulfonamide

2H-1,2, 4-Benzothiadiazine-7-sulfonamide, 6-chloro-3, 4-dihydro-2-methyl-3-[[ (2,2,2-trifluoroethyl)thio]methyl]-, 1, 1-dioxide

2H-1,2,4-Benzothiadiazine-7-sulfonamide,6-chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoroethyl)thio]methyl]-,1,1-dioxide

2-Methyl-3-(b,b,b-trifluoroethylthiomethyl)-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-Dioxide

2-Methyl-3-(β,β,β-trifluoroethylthiomethyl)-6-chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide

6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1&λ

6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1&λ;<sup>6</sup>,2,4-benzothiadiazine-7-sulfonamide

6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1?⁶,2,4-benzothiadiazine-7-sulfonamide

6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ⁶,2,4-benzothiadiazine-7-sulfonamide

6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydrobenzo[e][1,2,4]thiadiazine-7-sulfonamide

6-chloro-2-methyl-1,1-dioxo-3-{[(2,2,2-trifluoroethyl)sulfanyl]methyl}-3,4-dihydro-2H-1λ6,2,4-benzothiadiazine-7-sulfonamide

6-chloro-2-methyl-1,1-dioxo-3-{[(2,2,2-trifluoroethyl)sulfanyl]methyl}-3,4-dihydro-2H-1λ⁶,2,4-benzothiadiazine-7-sulfonamide

6-Chloro-2-methyl-3-([(2,2,2-trifluoroethyl)sulfanyl]methyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

6-Chloro-3,4-dihydro-2-methyl-3-(((2,2,2-trifluoroethyl)thio)methyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

6-Chloro-3,4-dihydro-2-methyl-3-[[(2,2, 2-trifluoroethyl)thio]methyl]-2H-1,2, 4-benzothiadiazine-7-sulfonamide 1,1-dioxide

6-Chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoroethyl)thio]methyl]-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide

6-Chloro-3,4-dihydro-2-methyl-7-sulphamoyl-3-(2,2,2-trifluoroethylthiomethyl)-2H-benzo-1,2,4-thiadiazine 1,1-dioxide

KS-1466

P-2525|Renese®

politiazida

polythiazidum

Renese®

RENESE-R

Thiazide [Wiki]

WLN: T66 BSWN EM DHJ C1 D1S1XFFF HG ISZW

политиазид

بوليثيازيد

泊利噻嗪

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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1187 [DBID]

36780APV5N [DBID]

UNII:36780APV5N [DBID]

BRN 0770371 [DBID]

C07766 [DBID]

CCRIS 6094 [DBID]

D00657 [DBID]

HSDB 850 [DBID]

NSC 108161 [DBID]

NSC108161 [DBID]

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Experimental data
Predicted - ACD/Labs
Predicted - EPISuite
Predicted - ChemAxon

Experimental Physico-chemical Properties
- Experimental Melting Point:
  
  214 °C Jean-Claude Bradley Open Melting Point Dataset 16961, 21624
Miscellaneous
- Safety:
  
  C03AA05 Wikidata Q7227099

Gas Chromatography

Retention Index (Normal Alkane):

Retention Index (Linear):

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density:	1.6±0.1 g/cm³
Boiling Point:	580.1±60.0 °C at 760 mmHg
Vapour Pressure:	0.0±1.6 mmHg at 25°C
Enthalpy of Vaporization:	86.8±3.0 kJ/mol
Flash Point:	304.7±32.9 °C
Index of Refraction:	1.566
Molar Refractivity:	89.8±0.4 cm³
#H bond acceptors:	7
#H bond donors:	3
#Freely Rotating Bonds:	5
#Rule of 5 Violations:	0

ACD/LogP:	1.55
ACD/LogD (pH 5.5):	1.59
ACD/BCF (pH 5.5):	9.47
ACD/KOC (pH 5.5):	173.99
ACD/LogD (pH 7.4):	1.58
ACD/BCF (pH 7.4):	9.36
ACD/KOC (pH 7.4):	171.90
Polar Surface Area:	152 Å²
Polarizability:	35.6±0.5 10^-24cm³
Surface Tension:	48.3±3.0 dyne/cm
Molar Volume:	275.3±3.0 cm³

Predicted data is generated using the US Environmental Protection Agency�s EPISuite™

                        
 Log Octanol-Water Partition Coef (SRC):
    Log Kow (KOWWIN v1.67 estimate) =  1.00
    Log Kow (Exper. database match) =  1.90
       Exper. Ref:  Sangster (1994)

 Boiling Pt, Melting Pt, Vapor Pressure Estimations (MPBPWIN v1.42):
    Boiling Pt (deg C):  529.30  (Adapted Stein & Brown method)
    Melting Pt (deg C):  226.29  (Mean or Weighted MP)
    VP(mm Hg,25 deg C):  4.81E-011  (Modified Grain method)
    MP  (exp database):  214 deg C
    Subcooled liquid VP: 4.94E-009 mm Hg (25 deg C, Mod-Grain method)

 Water Solubility Estimate from Log Kow (WSKOW v1.41):
    Water Solubility at 25 deg C (mg/L):  3.66
       log Kow used: 1.90 (expkow database)
       no-melting pt equation used

 Water Sol Estimate from Fragments:
    Wat Sol (v1.01 est) =  67.391 mg/L

 ECOSAR Class Program (ECOSAR v0.99h):
    Class(es) found:
       Neutral Organics

 Henrys Law Constant (25 deg C) [HENRYWIN v3.10]:
   Bond Method :   1.43E-012  atm-m3/mole
   Group Method:   Incomplete
 Henrys LC [VP/WSol estimate using EPI values]:  7.606E-012 atm-m3/mole

 Log Octanol-Air Partition Coefficient (25 deg C) [KOAWIN v1.10]:
  Log Kow used:  1.90  (exp database)
  Log Kaw used:  -10.233  (HenryWin est)
      Log Koa (KOAWIN v1.10 estimate):  12.133
      Log Koa (experimental database):  None

 Probability of Rapid Biodegradation (BIOWIN v4.10):
   Biowin1 (Linear Model)         :  -0.3985
   Biowin2 (Non-Linear Model)     :   0.0000
 Expert Survey Biodegradation Results:
   Biowin3 (Ultimate Survey Model):   1.3726  (recalcitrant)
   Biowin4 (Primary Survey Model) :   2.6650  (weeks-months)
 MITI Biodegradation Probability:
   Biowin5 (MITI Linear Model)    :  -0.5677
   Biowin6 (MITI Non-Linear Model):   0.0000
 Anaerobic Biodegradation Probability:
   Biowin7 (Anaerobic Linear Model): -0.0230
 Ready Biodegradability Prediction:   NO

Hydrocarbon Biodegradation (BioHCwin v1.01):
    Structure incompatible with current estimation method!

 Sorption to aerosols (25 Dec C)[AEROWIN v1.00]:
  Vapor pressure (liquid/subcooled):  6.59E-007 Pa (4.94E-009 mm Hg)
  Log Koa (Koawin est  ): 12.133
   Kp (particle/gas partition coef. (m3/ug)):
       Mackay model           :  4.55 
       Octanol/air (Koa) model:  0.333 
   Fraction sorbed to airborne particulates (phi):
       Junge-Pankow model     :  0.994 
       Mackay model           :  0.997 
       Octanol/air (Koa) model:  0.964 

 Atmospheric Oxidation (25 deg C) [AopWin v1.92]:
   Hydroxyl Radicals Reaction:
      OVERALL OH Rate Constant = 220.1969 E-12 cm3/molecule-sec
      Half-Life =     0.049 Days (12-hr day; 1.5E6 OH/cm3)
      Half-Life =     0.583 Hrs
   Ozone Reaction:
      No Ozone Reaction Estimation
   Reaction With Nitrate Radicals May Be Important!
   Fraction sorbed to airborne particulates (phi): 0.996 (Junge,Mackay)
    Note: the sorbed fraction may be resistant to atmospheric oxidation

 Soil Adsorption Coefficient (PCKOCWIN v1.66):
      Koc    :  4427
      Log Koc:  3.646 

 Aqueous Base/Acid-Catalyzed Hydrolysis (25 deg C) [HYDROWIN v1.67]:
    Rate constants can NOT be estimated for this structure!

 Bioaccumulation Estimates from Log Kow (BCFWIN v2.17):
   Log BCF from regression-based method = 0.763 (BCF = 5.794)
       log Kow used: 1.90 (expkow database)

 Volatilization from Water:
    Henry LC:  1.43E-012 atm-m3/mole  (estimated by Bond SAR Method)
    Half-Life from Model River: 8.587E+008  hours   (3.578E+007 days)
    Half-Life from Model Lake : 9.368E+009  hours   (3.903E+008 days)

 Removal In Wastewater Treatment:
    Total removal:               2.16  percent
    Total biodegradation:        0.09  percent
    Total sludge adsorption:     2.07  percent
    Total to Air:                0.00  percent
      (using 10000 hr Bio P,A,S)

 Level III Fugacity Model:
           Mass Amount    Half-Life    Emissions
            (percent)        (hr)       (kg/hr)
   Air       0.0013          1.17         1000       
   Water     26.4            4.32e+003    1000       
   Soil      73.5            8.64e+003    1000       
   Sediment  0.0954          3.89e+004    0          
     Persistence Time: 2.68e+003 hr

Click to predict properties on the Chemicalize site

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Polythiazide

More details:

Experimental Melting Point:

Safety:

Retention Index (Normal Alkane):

Retention Index (Linear):

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