PLANNED MAINTENANCE

There will be scheduled maintenance work beginning on Wednesday 26th February 2020 from 11:00 AM through to 12.00 PM (GMT).

During this time, you may not be able to log into ChemSpider. We apologise for any inconvenience this might cause and thank you for your patience.


ChemSpider 2D Image | GW5074 | C15H8Br2INO2

GW5074

  • Molecular FormulaC15H8Br2INO2
  • Average mass520.942 Da
  • Monoisotopic mass518.796631 Da
  • ChemSpider ID4750213
  • Double-bond stereo - Double-bond stereo


More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(3Z)-3-(3,5-Dibrom-4-hydroxybenzyliden)-5-iod-1,3-dihydro-2H-indol-2-on [German] [ACD/IUPAC Name]
(3Z)-3-(3,5-Dibromo-4-hydroxybenzylidene)-5-iodo-1,3-dihydro-2H-indol-2-one [ACD/IUPAC Name]
(3Z)-3-(3,5-Dibromo-4-hydroxybenzylidène)-5-iodo-1,3-dihydro-2H-indol-2-one [French] [ACD/IUPAC Name]
220904-83-6 [RN]
2H-Indol-2-one, 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo-, (3Z)- [ACD/Index Name]
3-(3,5-Dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one
3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one
5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone
GW5074
MFCD03453076
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

EU-0100510 [DBID]
G6416_SIGMA [DBID]
GW-5074 [DBID]
Lopac-G-6416 [DBID]
NCGC00015478-01 [DBID]
NCGC00025134-01 [DBID]
Tocris-1381 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Safety:

      5 Axon Medchem 1984
      H303;H313;H317;H333;H334;H335;H373 Axon Medchem 1984
      no pictogram Axon Medchem 1984
      P101;P102;P103;P260;P262;P263;P264;P270;P280;P304;P312;P340 Axon Medchem 1984
      Sold for research purposes under agreement from Glaxo Wellcome Inc and Glaxo Group Ltd. Tocris Bioscience 1381
      Warning Axon Medchem 1984
    • Bio Activity:

      Enzymes Tocris Bioscience 1381
      GW 5074 is a potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC50 = 9 nM); displays ? 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fms.; IC50 value: 9 nM [1]; Target: GW5074 is a potent and specific inhibitor of c-Raf with IC50 of 9 nM and has no effect of MKK6, MKK7, p38 MAP kinase and cdks in vitro. MedChem Express HY-10542
      Kinases Tocris Bioscience 1381
      MAPK MedChem Express HY-10542
      MAPK ; MedChem Express HY-10542
      Potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC50 = 9 nM). Displays ? 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. Tocris Bioscience 1381
      Potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC50 = 9 nM). Displays greater than or equal to 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. Tocris Bioscience 1381
      Potent, selective c-Raf1 kinase inhibitor Tocris Bioscience 1381
      Raf MedChem Express HY-10542
      Raf Kinase Tocris Bioscience 1381

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 2.2±0.1 g/cm3
Boiling Point: 561.4±50.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.6 mmHg at 25°C
Enthalpy of Vaporization: 87.6±3.0 kJ/mol
Flash Point: 293.3±30.1 °C
Index of Refraction: 1.790
Molar Refractivity: 98.1±0.3 cm3
#H bond acceptors: 3
#H bond donors: 2
#Freely Rotating Bonds: 1
#Rule of 5 Violations: 2
ACD/LogP: 6.36
ACD/LogD (pH 5.5): 5.18
ACD/BCF (pH 5.5): 4880.94
ACD/KOC (pH 5.5): 14337.14
ACD/LogD (pH 7.4): 4.00
ACD/BCF (pH 7.4): 317.29
ACD/KOC (pH 7.4): 932.00
Polar Surface Area: 49 Å2
Polarizability: 38.9±0.5 10-24cm3
Surface Tension: 72.0±3.0 dyne/cm
Molar Volume: 231.7±3.0 cm3

Click to predict properties on the Chemicalize site






Advertisement