ChemSpider 2D Image | GW5074 | C15H8Br2INO2

GW5074

  • Molecular FormulaC15H8Br2INO2
  • Average mass520.942 Da
  • Monoisotopic mass518.796631 Da
  • ChemSpider ID4750213
  • Double-bond stereo - Double-bond stereo


More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(3Z)-3-(3,5-Dibrom-4-hydroxybenzyliden)-5-iod-1,3-dihydro-2H-indol-2-on [German] [ACD/IUPAC Name]
(3Z)-3-(3,5-Dibromo-4-hydroxybenzylidene)-5-iodo-1,3-dihydro-2H-indol-2-one [ACD/IUPAC Name]
(3Z)-3-(3,5-Dibromo-4-hydroxybenzylidène)-5-iodo-1,3-dihydro-2H-indol-2-one [French] [ACD/IUPAC Name]
220904-83-6 [RN]
2H-Indol-2-one, 3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-1,3-dihydro-5-iodo-, (3Z)- [ACD/Index Name]
3-(3,5-Dibromo-4-hydroxybenzyliden)-5-iodo-1,3-dihydroindol-2-one
3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one
5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone
GW5074
MFCD03453076
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

EU-0100510 [DBID]
G6416_SIGMA [DBID]
GW-5074 [DBID]
Lopac-G-6416 [DBID]
NCGC00015478-01 [DBID]
NCGC00025134-01 [DBID]
Tocris-1381 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Safety:

      5 Axon Medchem 1984
      H303;H313;H317;H333;H334;H335;H373 Axon Medchem 1984
      no pictogram Axon Medchem 1984
      P101;P102;P103;P260;P262;P263;P264;P270;P280;P304;P312;P340 Axon Medchem 1984
      Sold for research purposes under agreement from Glaxo Wellcome Inc and Glaxo Group Ltd. Tocris Bioscience 1381
      Warning Axon Medchem 1984
    • Bio Activity:

      Enzymes Tocris Bioscience 1381
      GW 5074 is a potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC50 = 9 nM); displays ? 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fms.; IC50 value: 9 nM [1]; Target: GW5074 is a potent and specific inhibitor of c-Raf with IC50 of 9 nM and has no effect of MKK6, MKK7, p38 MAP kinase and cdks in vitro. MedChem Express HY-10542
      Kinases Tocris Bioscience 1381
      MAPK MedChem Express HY-10542
      MAPK ; MedChem Express HY-10542
      Potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC50 = 9 nM). Displays ? 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. Tocris Bioscience 1381
      Potent, selective and cell-permeable c-Raf1 kinase inhibitor (IC50 = 9 nM). Displays greater than or equal to 100-fold selectivity for raf kinase over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. Tocris Bioscience 1381
      Potent, selective c-Raf1 kinase inhibitor Tocris Bioscience 1381
      Raf MedChem Express HY-10542
      Raf Kinase Tocris Bioscience 1381

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 2.2±0.1 g/cm3
Boiling Point: 561.4±50.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.6 mmHg at 25°C
Enthalpy of Vaporization: 87.6±3.0 kJ/mol
Flash Point: 293.3±30.1 °C
Index of Refraction: 1.790
Molar Refractivity: 98.1±0.3 cm3
#H bond acceptors: 3
#H bond donors: 2
#Freely Rotating Bonds: 1
#Rule of 5 Violations: 2
ACD/LogP: 6.36
ACD/LogD (pH 5.5): 5.18
ACD/BCF (pH 5.5): 4880.94
ACD/KOC (pH 5.5): 14337.14
ACD/LogD (pH 7.4): 4.00
ACD/BCF (pH 7.4): 317.29
ACD/KOC (pH 7.4): 932.00
Polar Surface Area: 49 Å2
Polarizability: 38.9±0.5 10-24cm3
Surface Tension: 72.0±3.0 dyne/cm
Molar Volume: 231.7±3.0 cm3

Click to predict properties on the Chemicalize site






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