ChemSpider 2D Image | Ibutamoren mesilate | C28H40N4O8S2

Ibutamoren mesilate

  • Molecular FormulaC28H40N4O8S2
  • Average mass624.769 Da
  • Monoisotopic mass624.228760 Da
  • ChemSpider ID4953379

  • defined stereocentres - 1 of 1 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1'-(2-Methylalanyl-O-benzyl-D-seryl)-1-(methylsulfonyl)-1,2-dihydrospiro[indole-3,4'-piperidine] methanesulfonate (1:1) [ACD/IUPAC Name]
159752-10-0 [RN]
Acide méthanesulfonique - 1'-(2-méthylalanyl-O-benzyl-D-séryl)-1-(méthylsulfonyl)-1,2-dihydrospiro[indole-3,4'-piperidine] (1:1) [French] [ACD/IUPAC Name]
Ibutamoren (mesylate)
Ibutamoren mesilate
Ibutamoren mesylate
Methansulfonsäure --1'-(2-methylalanyl-O-benzyl-D-seryl)-1-(methylsulfonyl)-1,2-dihydrospiro[indole-3,4'-piperidine] (1:1) [German] [ACD/IUPAC Name]
Propanamide, 2-amino-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4'-piperidin]-1'-yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methyl-, methanesulfonate (1:1) [ACD/Index Name]
(R)-2-amino-N-(3-(benzyloxy)-1-(1-(methylsulfonyl)spiro[indoline-3,4'-piperidin]-1'-yl)-1-oxopropan-2-yl)-2-methylpropanamide methanesulfonate
(R)-2-amino-N-(3-(benzyloxy)-1-(1-(methylsulfonyl)spiro[indoline-3,4'-piperidine]-1'-yl)-1-oxopropan-2-yl)-2-methylpropanamide methanesulfonate
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

R90JB6QJ2B [DBID]
L-163191 [DBID]
MK-0677 [DBID]
MK-677 [DBID]
UNII:R90JB6QJ2B [DBID]
UNII-R90JB6QJ2B [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      7-TM Receptors Tocris Bioscience 5272
      Ghrelin Receptors Tocris Bioscience 5272
      GHSR MedChem Express HY-50844
      GPCR/G protein MedChem Express HY-50844
      GPCR/G protein; MedChem Express HY-50844
      High affinity ghrelin receptor agonist Tocris Bioscience 5272
      High affinity ghrelin receptor agonist (pKi = 8.14). Growth hormone (GH) secretagog; stimulates GH release from rat pituitary cells in vitro (EC50 = 1.3 nM) and enhances GH plasma levels in vivo. Also attenuates isoproterenol-induced lipolysis in rat adipocytes in vitro. Orally bioavailable. Tocris Bioscience 5272
      High affinity ghrelin receptor agonist (pKi = 8.14). Growth hormone (GH) secretagog; stimulates GH release from rat pituitary cells in vitro (EC50 = 1.3 nM) and enhances GH plasma levels in vivo. Also attenuates isoproterenol-induced lipolysis in rat adipocytes in vitro. Orally bioavailable. Tocris Bioscience 5272
      Ibutamoren mesylate (MK-0677) is an orally active nonpeptide growth hormone (GH) secretagogue. MedChem Express http://www.medchemexpress.com/zstk474.html, HY-50844
      Ibutamoren mesylate (MK-0677) is an orally active nonpeptide growth hormone (GH) secretagogue. ;IC50 Value: ;Target: GHSR;Ibutamoren mesylate (MK-0677) stimulates GH release through a pituitary and hypothalamic receptor that is different from the GH-releasing hormone receptor. MK-677is a drug which acts as a potent, orally active growth hormone secretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including growth hormone and IGF-1, but without affecting cortisol levels. It is currently under development as a potential treatment for reduced levels of these hormones, such as in growth hormone deficient children or elderly adults, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly. Ibutamoren mesylate (MK-0677) also alters MedChem Express HY-50844
      Peptide Receptors Tocris Bioscience 5272

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

No predicted properties have been calculated for this compound.

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