ChemSpider 2D Image | Raloxifene HCl | C28H28ClNO4S

Raloxifene HCl

  • Molecular FormulaC28H28ClNO4S
  • Average mass510.044 Da
  • Monoisotopic mass509.142761 Da
  • ChemSpider ID49573

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

[6-hydroxy-2-(4-hydroxyphényl)-1-benzothiophén-3-yl][4-(2-pipéridin-1-yléthoxy)phényl]méthanone chlorhydrate [French]
[6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl][4-(2-piperidin-1-ylethoxy)phenyl]methanone hydrochloride
[6-Hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl][4-(2-piperidin-1-ylethoxy)phenyl]methanonhydrochlorid
[6-Hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]{4-[2-(1-piperidinyl)ethoxy]phenyl}methanone hydrochloride (1:1) [ACD/IUPAC Name]
[6-Hydroxy-2-(4-hydroxyphényl)-1-benzothiophén-3-yl]{4-[2-(1-pipéridinyl)éthoxy]phényl}méthanone, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
[6-Hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]{4-[2-(1-piperidinyl)ethoxy]phenyl}methanonhydrochlorid (1:1) [German] [ACD/IUPAC Name]
[6-Hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]{4-[2-(piperidin-1-yl)ethoxy]phenyl}methanone hydrochloride (1:1)
[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone hydrochloride
1-[2-(4-{[6-Hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]carbonyl}phenoxy)ethyl]piperidinium chloride
6-Hydroxy-2-(p-hydroxyphenyl)benzo(b)thien-3-yl-p-(2-piperidinoethoxy)phenyl ketone hydrochloride
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

4F86W47BR6 [DBID]
LY 156758 [DBID]
D02217 [DBID]
EU-0101051 [DBID]
LY 139481 [DBID]
LY-139481 [DBID]
LY-156758 [DBID]
NSC706725 [DBID]
Prestwick_1035 [DBID]
R1402_SIGMA [DBID]
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      Estrogen/Progestogen Receptor antagonist; SERM agonist TargetMol T1549

    • Chemical Class:

      A hydrochloride salt resulting from the reaction of equimolar amounts of raloxifene and hydrogen chloride. ChEBI CHEBI:50740

    • Bio Activity:

      Biochemicals & small molecules Hello Bio HB2509
      Endocrinology/ Hormones TargetMol T1549
      Estrogen and Related Receptors Tocris Bioscience 2280
      Estrogen Receptor ;AO;SERM TargetMol T1549
      Estrogen Receptor/ERR MedChem Express HY-13738A
      Nuclear Receptors Tocris Bioscience 2280
      Others MedChem Express HY-13738A
      RaloxifeneHcl(LY156758 Hcl) is a second generation selective estrogen receptor antagonist. MedChem Express
      RaloxifeneHcl(LY156758 Hcl) is a second generation selective estrogen receptor antagonist.; Target: Estrogen receptor; Approved: September 14, 2007; Raloxifene activates TGF beta 3 promoter as a full agonist at nanomolar concentrations, and raloxifene inhibits the estrogen response element-containing vitellogenin promoter expression as a pure estrogen antagonist in transient transfection assays [1]. MedChem Express HY-13738A
      RaloxifeneHcl(LY156758 Hcl) is a second generation selective estrogen receptor antagonist.;Target: Estrogen receptorApproved: September 14, 2007Raloxifene activates TGF beta 3 promoter as a full agonist at nanomolar concentrations, and raloxifene inhibits the estrogen response element-containing vitellogenin promoter expression as a pure estrogen antagonist in transient transfection assays [1]. Raloxifene, has been demonstrated as a potent uncompetitive inhibitor of human liver aldehyde oxidase-catalyzed oxidation of phthalazine, vanillin, and nicotine-Delta1'(5')-iminium ion, with Ki values of 0.87 nM, 1.2 nM and 1.4 nM. Raloxifene has also been shown to be a noncompetitive inhibitor of an aldehyde oxidase-catalyzed reduction reaction of a hydroxamic acid-containing compound, with a Ki of 51 nM [2]. Raloxifene (3 mg/kg/day) has potent estrogenic activity on bone resorption and serum cholesterol, a lesser effect on bone formation, and minimal activity on uterine wet weight in o MedChem Express HY-13738A
      Receptors & Transporters/Nuclear hormone/Estrogen and related/Non-selective Hello Bio HB2509
      Selective estrogen receptor modulator Hello Bio HB2509
      Selective estrogen receptor modulator (K<sub>i</sub> values are 0.38 and 5.6 nM at Er&alpha; and Er&beta; respectively). Shows estrogenic activity in bone and anti-estrogenic activity in breast tissue. Also shows antitumor and autophagy inducing effects. Active <em> in vivo</em>. Hello Bio HB2509
      Selective estrogen receptor modulator (SERM) Tocris Bioscience 2280
      Selective estrogen receptor modulator (SERM) that binds to ER? and ER?, and tissue-dependently activates or blocks estrogen-induced transcription. Acts as an antiestrogen in breast and uterine tissue, but displays estrogen agonist activity in bone. In D12 rat hypothalamic cells, inhibits progesterone receptor induction by estrogen with an IC50 of 1 nM. Tocris Bioscience 2280
      Selective estrogen receptor modulator (SERM) that binds to ER? and ER?, and tissue-dependently activates or blocks estrogen-induced transcription. Acts as an antiestrogen in breast and uterine tissue, but displays estrogen agonist activity in bone. In D12 rat hypothalamic cells, inhibits progesterone receptor induction by estrogen with an IC50 of 1 nM. Tocris Bioscience 2280
      Selective estrogen receptor modulator (SERM) that binds to ERalpha and ERbeta, and tissue-dependently activates or blocks estrogen-induced transcription. Acts as an antiestrogen in breast and uterine tissue, but displays estrogen agonist activity in bone. In D12 rat hypothalamic cells, inhibits progesterone receptor induction by estrogen with an IC50 of 1 nM. Tocris Bioscience 2280

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


Advertisement