ChemSpider 2D Image | PF-05175157 | C23H27N5O2

PF-05175157

  • Molecular FormulaC23H27N5O2
  • Average mass405.493 Da
  • Monoisotopic mass405.216461 Da
  • ChemSpider ID52083240

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1'-(2-methyl-1H-1,3-benzodiazole-5-carbonyl)-1-(propan-2-yl)-1,4,6,7-tetrahydrospiro[indazole-5,4'-piperidin]-7-one
1301214-47-0 [RN]
1-isopropyl-1'-(2-methyl-1H-1,3-benzodiazole-5-carbonyl)-4,6-dihydrospiro[indazole-5,4'-piperidin]-7-one
1-Isopropyl-1'-[(2-methyl-1H-benzimidazol-6-yl)carbonyl]-1,4-dihydrospiro[indazole-5,4'-piperidin]-7(6H)-on [German] [ACD/IUPAC Name]
1-Isopropyl-1'-[(2-methyl-1H-benzimidazol-6-yl)carbonyl]-1,4-dihydrospiro[indazole-5,4'-piperidin]-7(6H)-one [ACD/IUPAC Name]
1-Isopropyl-1'-[(2-méthyl-1H-benzimidazol-6-yl)carbonyl]-1,4-dihydrospiro[indazole-5,4'-piperidin]-7(6H)-one [French] [ACD/IUPAC Name]
PF-05175157
Spiro[5H-indazole-5,4'-piperidin]-7(6H)-one, 1,4-dihydro-1'-[(2-methyl-1H-benzimidazol-6-yl)carbonyl]-1-(1-methylethyl)- [ACD/Index Name]
[1301214-47-0] [RN]
1'-(2-methyl-3H-benzimidazole-5-carbonyl)-1-propan-2-ylspiro[4,6-dihydroindazole-5,4'-piperidine]-7-one
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

P826WR56FI [DBID]
CCRIS 4693 [DBID]
UNII:P826WR56FI [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Safety:

      Sold for research purposes under agreement from Pfizer Inc. Tocris Bioscience 5790

    • Bio Activity:

      Acetyl-CoA carboxylase (ACC) 1 and 2 inhibitor Tocris Bioscience 5790
      Acetyl-CoA carboxylase (ACC) 2 and 1 inhibitor (IC50 values are 45 and 98 nM, respectively). Reduces hepatic and skeletal muscle malonyl-CoA levels in rats. Also inhibits hepatic de novo lipogenesis and reduces whole body respiratory exchange ratio in rats. Orally bioavailable. Tocris Bioscience 5790
      Cell Biology Tocris Bioscience 5790
      Cell Metabolism Tocris Bioscience 5790
      Lipid Metabolism Tocris Bioscience 5790
      Other Lipid Metabolism Tocris Bioscience 5790

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.4±0.1 g/cm3
Boiling Point: 692.0±55.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.2 mmHg at 25°C
Enthalpy of Vaporization: 101.4±3.0 kJ/mol
Flash Point: 372.3±31.5 °C
Index of Refraction: 1.710
Molar Refractivity: 114.6±0.5 cm3
#H bond acceptors: 7
#H bond donors: 1
#Freely Rotating Bonds: 2
#Rule of 5 Violations: 0
ACD/LogP: 1.34
ACD/LogD (pH 5.5): 1.87
ACD/BCF (pH 5.5): 10.66
ACD/KOC (pH 5.5): 122.29
ACD/LogD (pH 7.4): 2.51
ACD/BCF (pH 7.4): 47.43
ACD/KOC (pH 7.4): 544.12
Polar Surface Area: 84 Å2
Polarizability: 45.4±0.5 10-24cm3
Surface Tension: 55.4±7.0 dyne/cm
Molar Volume: 293.1±7.0 cm3

Click to predict properties on the Chemicalize site


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