ChemSpider 2D Image | Dexmedetomidine Hydrochloride | C13H17ClN2

Dexmedetomidine Hydrochloride

  • Molecular FormulaC13H17ClN2
  • Average mass236.740 Da
  • Monoisotopic mass236.108032 Da
  • ChemSpider ID5293298

  • defined stereocentres - 1 of 1 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(S)-4-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole Monohydrochloride
145108-58-3 [RN]
1H-Imidazole, 4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1) [ACD/Index Name]
1H-imidazole, 4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-, monohydrochloride
4-((S)-a,2,3-Trimethylbenzyl)imidazole Monohydrochloride
4-[(1S)-1-(2,3-diméthylphényl)éthyl]-1H-imidazole chlorhydrate
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride (1:1) [ACD/IUPAC Name]
4-[(1S)-1-(2,3-Diméthylphényl)éthyl]-1H-imidazole, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazolhydrochlorid
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazolhydrochlorid (1:1) [German] [ACD/IUPAC Name]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1018WH7F9I [DBID]
MPV-1440 [DBID]
UNII:1018WH7F9I [DBID]
UNII-1018WH7F9I [DBID]
  • Experimental Physico-chemical Properties

    • Experimental Solubility:

      <p>Soluble in water (100 mM), and in DMSO (100 mM)</p> Hello Bio HB2686
      DMSO 49 mg/mL; Water <1 mg/mL MedChem Express HY-17034A
      DMSO:>25 mg/ml; DMF?30 mg/ml; MedChem Express HY-17034A
      Soluble to 100 mM in water and to 100 mM in DMSO Tocris Bioscience 2749
  • Miscellaneous

    • Bio Activity:

      <p>Potent, highly selective ?2 adrenoceptor agonist (K<sub>i</sub> values are 1.08 and 1750 nM at ?2 and ?1 receptors, respectively). Active isomer of medetomidine. Shows greater selectivity for ?1-adrenoceptors than clonidine and UK14304. Shows various actions such as hypotensive, bradycardic, anxiolytic, hypothermic, sedative and analgesic properties.</p> Hello Bio HB2686
      7-TM Receptors Tocris Bioscience 2749
      Active isomer of medetomidine (Cat.No. 5160), a potent, highly selective ?2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for ?2- and ?1-adrenoceptors respectively). Displays greater selectivit y over ?1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects . Tocris Bioscience 2749
      Active isomer of medetomidine (Cat.No. 5160), a potent, highly selective ?2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for ?2- and ?1-adrenoceptors respectively). Displays greater selectivity over ?1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects. Tocris Bioscience 2749
      Active isomer of medetomidine (Cat.No. 5160), a potent, highly selective alpha2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for alpha2- and alpha1-adrenoceptors respectively). Displays greater selectivity over alpha1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects. Tocris Bioscience 2749
      Active isomer of medetomidine, a potent, highly selective alpha2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for alpha2- and alpha1-adrenoceptors respectively). Displays greater selectivity over alpha1-adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects. Racemate also available. Tocris Bioscience 2749
      Adrenergic Alpha-2 Receptors Tocris Bioscience 2749
      Adrenergic Receptor MedChem Express HY-17034A
      Adrenergic Receptors Tocris Bioscience 2749
      Dexmedetomidine Hydrochloride is an agonist of adrenergic alpha-2 receptor, which is used in veterinary medicine for its analgesic and sedative properties. MedChem Express
      Dexmedetomidine Hydrochloride is an agonist of adrenergic alpha-2 receptor, which is used in veterinary medicine for its analgesic and sedative properties.; Target: Adrenergic alpha-2 Receptor; Dexmedetomidine, acting at alpha(2A) adrenoceptors, must be present during the encoding process to decrease discrete cue fear memory; however, its ability to suppress contextual memory is likely the result of blocking the consolidation process [1]. MedChem Express HY-17034A
      Dexmedetomidine Hydrochloride is an agonist of adrenergic alpha-2 receptor, which is used in veterinary medicine for its analgesic and sedative properties.;Target: Adrenergic alpha-2 ReceptorDexmedetomidine, acting at alpha(2A) adrenoceptors, must be present during the encoding process to decrease discrete cue fear memory; however, its ability to suppress contextual memory is likely the result of blocking the consolidation process [1]. Dexmedetomidine had no analgesic effects in alpha(2A)-adrenoceptor KO mice [2]. Dexmedetomidine was effective in blocking these sympathomimetic actions of cocaine even in all 7 subjects who were homozygous for the Del322-325 polymorphism in the alpha2C AR, a loss-of-function mutation that is highly enriched in blacks [3]. MedChem Express HY-17034A
      GPCR/G protein MedChem Express HY-17034A
      GPCR/G protein; MedChem Express HY-17034A
      Potent, highly selective ?2 agonist. Active isomer of medetomidine (Cat. No. 2023) Tocris Bioscience 2749
      Potent, highly selective ?2 agonist. Active isomer of medetomidine (Cat. No. 5160) Tocris Bioscience 2749
      Potent, highly selective alpha2 agonist. Active isomer of medetomidine (Cat. No. 5160) Tocris Bioscience 2749

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


Advertisement