ChemSpider 2D Image | Donepezil hydrochloride | C24H30ClNO3

Donepezil hydrochloride

  • Molecular FormulaC24H30ClNO3
  • Average mass415.953 Da
  • Monoisotopic mass415.191437 Da
  • ChemSpider ID5539

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

120011-70-3 [RN]
1-Benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine Hydrochloride
1H-inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride
1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride (1:1) [ACD/Index Name]
2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride
2-[(1-Benzyl-4-piperidinyl)methyl]-5,6-dimethoxy-1-indanone hydrochloride
2-[(1-Benzyl-4-piperidinyl)methyl]-5,6-dimethoxy-1-indanone hydrochloride (1:1) [ACD/IUPAC Name]
2-[(1-Benzyl-4-pipéridinyl)méthyl]-5,6-diméthoxy-1-indanone, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
2-[(1-Benzyl-4-piperidinyl)methyl]-5,6-dimethoxy-1-indanonhydrochlorid (1:1) [German] [ACD/IUPAC Name]
2-[(1-benzylpipéridin-4-yl)méthyl]-5,6-diméthoxy-2,3-dihydro-1H-indén-1-one chlorhydrate [French]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

D00670 [DBID]
E 2020 [DBID]
E-2020 [DBID]
UN 2811 [DBID]
UN2811 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Safety:

      5 Axon Medchem 1438
      H303;H313;H317;H333;H334;H335;H373 Axon Medchem 1438
      IRRITANT Matrix Scientific 090394
      no pictogram Axon Medchem 1438
      None LKT Labs [D5753]
      P101;P102;P103;P260;P262;P263;P264;P270;P280;P304;P312;P340 Axon Medchem 1438
      P261; P262 Biosynth Q-201040
      Warning Axon Medchem 1438
    • Compound Source:

      synthetic; E-2020, BNAG Microsource [01504403]
    • Bio Activity:

      AChE MedChem Express HY-B0034
      Cholinesterases Tocris Bioscience 4385
      Donepezil Hcl(E-2020) is a noncompetitive acetylcholinesterase inhibitor, which can readily cross the blood brain barrier and increases the concentration of cortical acetylcholine. MedChem Express HY-B0034, http://www.medchemexpress.com/amrubicin.html
      Donepezil Hcl(E-2020) is a noncompetitive acetylcholinesterase inhibitor, which can readily cross the blood brain barrier and increases the concentration of cortical acetylcholine. ;IC50 Value:;Target: AChE;It is known that Donepezil Hydrochloride is a useful tool in the study of Alzheimer's disease. Studies indicate that Donepezil Hydrochloride protects the brain against diisopropylfluorophosphate-induced effects. Studies indicate that Donepezil Hydrochloride selectively inhibits acetylcholinesterase, whereas it has little effect on butyrylcholinesterase. Alternate studies suggest that Donepezil Hydrochloride increases the concentration of extracellular acetylcholine in the cerebral cortex and hippocampus of rats. MedChem Express HY-B0034
      Enzymes Tocris Bioscience 4385
      Esterases Tocris Bioscience 4385
      Neuronal Signaling MedChem Express HY-B0034
      Neuronal Signaling; MedChem Express HY-B0034
      Potent acetylcholinesterase inhibitor (IC50 = 5.7 nM). Displays 1252-fold selectivity for AChE over BuChE (IC50 = 7138 nM for BuChE). Orally active. Tocris Bioscience 4385
      Potent AChE inhibitor Tocris Bioscience 4385

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

No predicted properties have been calculated for this compound.

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