ChemSpider 2D Image | DL0310000 | C22H27ClN2O4S

DL0310000

  • Molecular FormulaC22H27ClN2O4S
  • Average mass450.979 Da
  • Monoisotopic mass450.138000 Da
  • ChemSpider ID56639

  • defined stereocentres - 2 of 2 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(+)-cis-3-(Acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Monohydrochloride
(+)-cis-Diltiazem Hydrochloride
(2S,3S)-(+)-cis-3-Acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride
(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate hydrochloride
(2S,3S)-5-[2-(Dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate hydrochloride (1:1) [ACD/IUPAC Name]
(2S,3S)-5-[2-(Dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-ylacetathydrochlorid
(2S,3S)-5-[2-(Dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl-acetathydrochlorid (1:1) [German] [ACD/IUPAC Name]
1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, (2S,3S)-, hydrochloride (1:1) [ACD/Index Name]
1,5-benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, (2S,3S)-, monohydrochloride
200-835-2 [EINECS]
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

4228706 [DBID]
CRD 401 [DBID]
CRD-401 [DBID]
OLH94387TE [DBID]
33286-22-5, 42399-41-7 [DBID]
D00616 [DBID]
D2521_SIGMA [DBID]
EU-0100327 [DBID]
MLS000028432 [DBID]
Prestwick_176 [DBID]
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  • Experimental Physico-chemical Properties
  • Predicted Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      A hydrochloride salt resulting from the reaction of equimolar amounts of diltiazem and hydrogen chloride. A calcium-channel blocker and vasodilator, it is used in the management of angina pectoris and hypertension. ChEBI https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:645509, CHEBI:645509

    • Bio Activity:

      Antihypertensive and cardioprotective agent; an inhibitor of L-type Ca2+ channels. Tocris Bioscience 0685, 685
      Ca2+ channel blocker (L-type) Tocris Bioscience 0685, 685
      Calcium Channel MedChem Express HY-14656
      Calcium Channels Tocris Bioscience 685
      Diltiazem hydrochloride is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions. MedChem Express
      Diltiazem hydrochloride is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.; Target: Calcium Channel; Diltiazem is a nondihydropyridine (non-DHP) member of the class of drugs known as calcium channel blockers, used in the treatment of hypertension, angina pectoris, and some types of arrhythmia. MedChem Express HY-14656
      Diltiazem hydrochloride is a benzothiazepine derivative with vasodilating action due to its antagonism of the actions of the calcium ion in membrane functions.;Target: Calcium ChannelDiltiazem is a nondihydropyridine (non-DHP) member of the class of drugs known as calcium channel blockers, used in the treatment of hypertension, angina pectoris, and some types of arrhythmia. It is a benzothiazepine, which differentiates it from the other classes of non-DHP calcium channel blockers such as the phenylalkylamines. Diltiazem is a potent vasodilator, increasing blood flow and variably decreasing the heart rate via strong depression of A-V node conduction. Its pharmacological activity is somewhat similar to verapamil [1]. Recent research has shown diltiazem is able to reduce cocaine cravings in drug-addicted rats. This is believed to be due to the effects of calcium blockers on dopaminergic and glutamatergic signalling in the brain. Diltiazem also enhances the analgesic effect of morphine MedChem Express HY-14656
      Ion Channels Tocris Bioscience 685
      Membrane Tranporter/Ion Channel MedChem Express HY-14656
      Membrane Tranporter/Ion Channel; MedChem Express HY-14656
      Voltage-gated Calcium Channels Tocris Bioscience 685

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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