ChemSpider 2D Image | HLCL-61 (hydrochloride) | C23H25ClN2O

HLCL-61 (hydrochloride)

  • Molecular FormulaC23H25ClN2O
  • Average mass380.910 Da
  • Monoisotopic mass380.165527 Da
  • ChemSpider ID57251262

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride (1:1) [ACD/IUPAC Name]
1-(9-Éthyl-9H-carbazol-3-yl)-N-(2-méthoxybenzyl)méthanamine, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanaminhydrochlorid (1:1) [German] [ACD/IUPAC Name]
1158279-20-9 [RN]
9H-Carbazole-3-methanamine, 9-ethyl-N-[(2-methoxyphenyl)methyl]-, hydrochloride (1:1) [ACD/Index Name]
HLCL-61 (hydrochloride)
1-(9-Ethyl-9H-carbazol-3-yl)-N-(2-methoxybenzyl)methanamine hydrochloride
1158279-20-9 (HCl)
  • Miscellaneous
    • Bio Activity:

      Cell Cycle/DNA Damage; MedChem Express HY-100025A
      HLCL-61 hydrochloride is a first-in-class small-molecule inhibitor of PRMT5. ;Target: PRMT5;In vitro: HLCL-61 shows effective inhibition of symmetric arginine dimethylation (me2) of histones H3 and H4 in AML samples, starting at 12 h post-treatment and persisting after 48 h. Treatment of AML cell lines (MV4-11 and THP-1) and primary blasts with HLCL-61 also resulted in a decrease of cell viability. HLCL-61 is also effective in promoting apoptosis in MV4-11 and THP-1 cells after 48 h.[1] MedChem Express HY-100025A
      HMTase MedChem Express HY-100025A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

No predicted properties have been calculated for this compound.

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