ChemSpider 2D Image | lifirafenib | C25H17F3N4O3

lifirafenib

  • Molecular FormulaC25H17F3N4O3
  • Average mass478.423 Da
  • Monoisotopic mass478.125275 Da
  • ChemSpider ID58145118
  • defined stereocentres - 3 of 3 defined stereocentres


More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1,8-Naphthyridin-2(1H)-one, 5-[[(1R,1aS,6bR)-1a,6b-dihydro-1-[6-(trifluoromethyl)-1H-benzimidazol-2-yl]-1H-cyclopropa[b]benzofuran-5-yl]oxy]-3,4-dihydro- [ACD/Index Name]
10554
1446090-79-4 [RN]
5-(((1R,1AS,6bR)-1-(6-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-1a,6b-dihydro-1H-cyclopropa[b]benzofuran-5-yl)oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one
5-({(1R,1aS,6bR)-1-[6-(Trifluormethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-on [German] [ACD/IUPAC Name]
5-({(1R,1aS,6bR)-1-[6-(Trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one [ACD/IUPAC Name]
5-({(1R,1aS,6bR)-1-[6-(Trifluorométhyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphtyridin-2(1H)-one [French] [ACD/IUPAC Name]
8762XZS5ZF
BEIGENE-283
lifirafenib [INN]
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Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.5±0.1 g/cm3
Boiling Point: 705.6±60.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.2 mmHg at 25°C
Enthalpy of Vaporization: 103.2±3.0 kJ/mol
Flash Point: 380.6±32.9 °C
Index of Refraction: 1.673
Molar Refractivity: 118.1±0.3 cm3
#H bond acceptors: 7
#H bond donors: 2
#Freely Rotating Bonds: 4
#Rule of 5 Violations: 0
ACD/LogP: 3.92
ACD/LogD (pH 5.5): 4.30
ACD/BCF (pH 5.5): 1049.58
ACD/KOC (pH 5.5): 4851.05
ACD/LogD (pH 7.4): 4.36
ACD/BCF (pH 7.4): 1211.94
ACD/KOC (pH 7.4): 5601.45
Polar Surface Area: 89 Å2
Polarizability: 46.8±0.5 10-24cm3
Surface Tension: 62.0±3.0 dyne/cm
Molar Volume: 314.9±3.0 cm3

Click to predict properties on the Chemicalize site






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