ChemSpider 2D Image | Dibucaine hydrochloride | C20H30ClN3O2

Dibucaine hydrochloride

  • Molecular FormulaC20H30ClN3O2
  • Average mass379.924 Da
  • Monoisotopic mass379.202667 Da
  • ChemSpider ID5853

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

2-Butoxy-N-(2-diethylaminoethyl)-4-quinolinecarboxamide hydrochloride
2-Butoxy-N-[2-(diethylamino)ethyl]-4-chinolincarboxamidhydrochlorid (1:1) [German] [ACD/IUPAC Name]
2-Butoxy-N-[2-(diéthylamino)éthyl]-4-quinoléinecarboxamide, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide hydrochloride (1:1) [ACD/IUPAC Name]
2-Butoxy-N-[2-(diethylamino)ethyl]-4-quinolinecarboxamide Monohydrochloride
2-Butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide hydrochloride (1:1)
4-Quinolinecarboxamide, 2-butoxy-N-[2-(diethylamino)ethyl]-, hydrochloride (1:1) [ACD/Index Name]
61-12-1 [RN]
benzolin
Benzolin (VAN)
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

C 3225 [DBID]
D02220 [DBID]
D0638_SIAL [DBID]
MLS000028429 [DBID]
SMR000058369 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Appearance:

      white powder Oxford University Chemical Safety Data (No longer updated) More details
    • Stability:

      Stable. Incompatible with strong oxidizing agents. Protect from moisture. Oxford University Chemical Safety Data (No longer updated) More details
    • Toxicity:

      IPR-RAT LD50 22 mg kg-1, SCU-RAT LD50 27 mg kg-1, IVN-RAT LD50 52 mg kg-1, ORL-BWD LD50 42 mg kg-1 Oxford University Chemical Safety Data (No longer updated) More details
    • Safety:

      Safety glasses, adequate ventilation. Oxford University Chemical Safety Data (No longer updated) More details
      Xn Abblis Chemicals AB1004834
    • Target Organs:

      Sodium Channel;ChE inhibitor TargetMol T0364L
    • Chemical Class:

      The monohydrochloride salt of cinchocaine. It is used in creams, ointments and suppositories for temporary relief of pain and itching associated with skin and anorectal conditions. ChEBI CHEBI:59735
    • Compound Source:

      synthetic Microsource [01500236]
    • Bio Activity:

      Dibucaine Hydrochloride is a local anesthetic of the amide type now generally used for surface anesthesia. MedChem Express
      Dibucaine Hydrochloride is a local anesthetic of the amide type now generally used for surface anesthesia.; Target: Sodium Channel; Dibucaine is an amide local anesthetic. MedChem Express HY-B0552A
      Dibucaine Hydrochloride is a local anesthetic of the amide type now generally used for surface anesthesia.;Target: Sodium ChannelDibucaine is an amide local anesthetic. Dibucaine reduced the degradation of BSA-gold complex in the reservosomes, which was not caused either by an inhibition of the whole proteolytic activity of the parasite or by a reduction on the expression levels of cruzipain [1].Dibucaine, a quaternary ammonium compound, inhibited SChE to a minimum within 2 min in a reversible manner. The inhibition was very potent. It had an IC(50) of 5.3 microM with BuTch or 3.8 microM with AcTch. The inhibition was competitive with respect to BuTch with a K(i) of 1.3 microM and a linear-mixed type (competitive/noncompetitive) with respect to AcTch with inhibition constants, K(i) and K(I) of 0.66 and 2.5 microM, respectively. Dibucaine possesses a butoxy side chain that is similar to the butryl group of BuTch and longer by an ethylene group from AcTch [2]. MedChem Express HY-B0552A
      Membrane Tranporter/Ion Channel MedChem Express HY-B0552A
      Membrane Tranporter/Ion Channel; MedChem Express HY-B0552A
      Membrane Transporter/Ion Channel; Neuroscience TargetMol T0364L
      Sodium Channel MedChem Express HY-B0552A
      Sodium channel ;ChE TargetMol T0364L

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

No predicted properties have been calculated for this compound.

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