ChemSpider 2D Image | MPEP hydrochloride | C14H12ClN

MPEP hydrochloride

  • Molecular FormulaC14H12ClN
  • Average mass229.705 Da
  • Monoisotopic mass229.065826 Da
  • ChemSpider ID7970355

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

219911-35-0 [RN]
2-Methyl-6-(phenylethinyl)pyridinhydrochlorid (1:1) [German] [ACD/IUPAC Name]
2-Methyl-6-(phenylethynyl)pyridine hydrochloride
2-Methyl-6-(phenylethynyl)pyridine hydrochloride (1:1) [ACD/IUPAC Name]
2-Méthyl-6-(phényléthynyl)pyridine, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
6-Methyl-2-(phenylethynyl)pyridine hydrochloride
MFCD02262119 [MDL number]
MPEP hydrochloride
Pyridine, 2-methyl-6-(2-phenylethynyl)-, hydrochloride (1:1) [ACD/Index Name]
[219911-35-0]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CHEBI:64158 [DBID]
AU9X845ZWM [DBID]
EU-0100738 [DBID]
M5435_SIGMA [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Safety:

      5 Axon Medchem 1222
      H303;H313;H317;H333;H334;H335;H373 Axon Medchem 1222
      no pictogram Axon Medchem 1222
      P101;P102;P103;P260;P262;P263;P264;P270;P280;P304;P312;P340 Axon Medchem 1222
      Warning Axon Medchem 1222
    • Chemical Class:

      A hydrochloride salt obtained by reaction of 2-methyl-6-(phenylethynyl)pyridine with one equivalent of hydrochloric acid. Potent and highly selective non-competitive antagonist at the mGlu<smallsub>5< /smallsub> receptor subtype (IC<smallsub>50</smallsub> = 36 nM) and a positive allosteric modulator at mGlu<smallsub>4</smallsub> receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. ChEBI CHEBI:64158
    • Bio Activity:

      7-TM Receptors Tocris Bioscience 1212
      Glutamate (Metabotropic) Group I Receptors Tocris Bioscience 1212
      Glutamate (Metabotropic) Receptors Tocris Bioscience 1212
      GPCR/G protein; MedChem Express HY-14609
      mGlu5 antagonist and positive allosteric modulator at mGlu4 Tocris Bioscience 1212
      mGluR MedChem Express HY-14609
      Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administ ration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. Also available as part of the Group I mGlu Receptor Tocriset™. Tocris Bioscience 1212
      Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. Also available as part of the Group I mGlu Receptor Tocriset?. Tocris Bioscience 1212

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

No predicted properties have been calculated for this compound.

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