ChemSpider 2D Image | MPEP | C14H12ClN

MPEP

  • Molecular FormulaC14H12ClN
  • Average mass229.705 Da
  • Monoisotopic mass229.065826 Da
  • ChemSpider ID7970355

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

219911-35-0 [RN]
2-methyl-6-(2-phenylethynyl)pyridine hydrochloride
2-Methyl-6-(phenylethinyl)pyridinhydrochlorid (1:1) [German] [ACD/IUPAC Name]
2-Methyl-6-(phenylethynyl)pyridine hydrochloride
2-Methyl-6-(phenylethynyl)pyridine hydrochloride (1:1) [ACD/IUPAC Name]
2-Méthyl-6-(phényléthynyl)pyridine, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
6-Methyl-2-(phenylethynyl)pyridine hydrochloride
96206-92-7 [RN]
MFCD02262119 [MDL number]
MPEP
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CHEBI:64158 [DBID]
AU9X845ZWM [DBID]
EU-0100738 [DBID]
M5435_SIGMA [DBID]
  • Experimental Physico-chemical Properties

    • Experimental Solubility:

      Soluble in DMSO (100mM) and in ethanol (100 mM) Hello Bio HB0426
      Soluble to 5 mM in water and to 100 mM in DMSO Tocris Bioscience 1212
      Soluble to 5 mM in water with gentle warming and to 100 mM in DMSO Tocris Bioscience 1212
  • Miscellaneous

    • Chemical Class:

      A hydrochloride salt obtained by reaction of 2-methyl-6-(phenylethynyl)pyridine with one equivalent of hydrochloric acid. Potent and highly selective non-competitive antagonist at the mGlu<smallsub>5< /smallsub> receptor subtype (IC<smallsub>50</smallsub> = 36 nM) and a positive allosteric modulator at mGlu<smallsub>4</smallsub> receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. ChEBI CHEBI:64158
      A hydrochloride salt obtained by reaction of 2-methyl-6-(phenylethynyl)pyridine with one equivalent of hydrochloric acid. Potent and highly selective non-competitive antagonist at the mGlu5 receptor s ubtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. ChEBI CHEBI:64158

    • Bio Activity:

      <p>MPEP hydrochloride is a potent, selective and non-competitive mGlu<sub>5</sub> receptor antagonist (IC<sub>50</sub> = 36 nM) and also a mGlu<sub>4</sub> receptor positive allosteric modulator (PAM).</p> <p><br />MPEP prevents induction of various types of long term potentiation (LTP) and long term depression (LTD).</p> <p>MPEP also suppresses addiction-like behaviour for cocaine, ethanol and nicotine in various models of addiction. MPEP is blood-brain barrier (BBB) permeable and is active <em> in vivo</em>.</p> <p><br />Water soluble&nbsp;<a href="/mtep-hydrochloride.html" title="MTEP hydrochloride high selective mGlu5 antagonist" target="_self">MTEP hydrochloride</a> is also available.</p> Hello Bio HB0426
      <p>MPEP hydrochloride is a potent, selective and non-competitive mGlu<sub>5</sub> receptor antagonist (IC<sub>50</sub> = 36 nM) and also a mGlu<sub>4</sub> receptor positive allosteric modulator (PAM).</p> <p><br />MPEP prevents induction of various types of long term potentiation (LTP) and long term depression (LTD).</p> <p>MPEP also suppresses addiction-like behaviour for cocaine, ethanol and nicotine in various models of addiction. MPEP is blood-brain barrier (BBB) permeable and is active <em> in vivo</em>.</p> <p><br />Water soluble&nbsp;<a href=/mtep-hydrochloride.html title=MTEP hydrochloride high selective mGlu5 antagonist target=_self>MTEP hydrochloride</a> is also available.</p> Hello Bio HB0426
      7-TM Receptors Tocris Bioscience 1212
      Biochemicals & small molecules/Antagonists & inhibitors Hello Bio HB0426
      Glutamate (Metabotropic) Group I Receptors Tocris Bioscience 1212
      Glutamate (Metabotropic) Receptors Tocris Bioscience 1212
      GPCR/G protein; MedChem Express HY-14609
      mGlu5 antagonist and positive allosteric modulator at mGlu4 Tocris Bioscience 1212
      mGluR MedChem Express HY-14609
      Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administ ration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. Also available as part of the Group I mGlu Receptor Tocriset™. Tocris Bioscience 1212
      Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw. Also available as part of the Group I mGlu Receptor Tocriset?. Tocris Bioscience 1212
      Potent, selective mGluR<sub>5</sub> antagonist / mGluR<sub>4</sub> positive allosteric modulator Hello Bio HB0426
      Receptors & Transporters/G protein coupled receptors/Metabotropic glutamate/Group I (mGlu<sub>5</sub>, mGlu<sub>1</sub>) Hello Bio HB0426

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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