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Nintedanib

Molecular FormulaC₃₁H₃₃N₅O₄
Average mass539.625 Da
Monoisotopic mass539.253235 Da
ChemSpider ID7985471

- Double-bond stereo

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Featured data source

Names and Synonyms
Database ID(s)

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(3Z)-3-{[(4-{Méthyl[2-(4-méthyl-1-pipérazinyl)acétyl]amino}phényl)amino](phényl)méthylène}-2-oxo-6-indolinecarboxylate de méthyle [French] [ACD/IUPAC Name]

1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)- [ACD/Index Name]

3-[[4-[methyl-[2-(4-methyl-1-piperazinyl)-1-oxoethyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylic acid methyl ester

656247-17-5 [RN]

Methyl (3Z)-3-{[(4-{methyl[(4-methyl-1-piperazinyl)acetyl]amino}phenyl)amino](phenyl)methylene}-2-oxo-6-indolinecarboxylate [ACD/IUPAC Name]

Methyl-(3Z)-3-{[(4-{methyl[(4-methyl-1-piperazinyl)acetyl]amino}phenyl)amino](phenyl)methylen}-2-oxo-6-indolincarboxylat [German] [ACD/IUPAC Name]

Nintedanib [INN] [USAN] [Wiki]

Nintedanib [Spanish] [INN]

Nintédanib [French] [INN]

Nintedanibum [Latin] [INN]

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Ofev [Trade name]

Vargatef [Trade name]

(3z)-2,3-dihydro-3-(((4-(methyl(2-(4-methyl-1-piperazinyl)acetyl)amino)phenyl)amino)phenylmethylene)-2-oxo-1h-indole-6-carboxylic acid methyl ester

(3Z)-2,3-Dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-indole-6-carboxylic acid methyl ester

(3Z)-2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-1H-indole-6-carboxylic acid, methyl ester

(3Z)-2-keto-3-[[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]amino]-phenyl-methylene]indoline-6-carboxylic acid methyl ester

(3Z)-3-[[[4-[methyl-[2-(4-methyl-1-piperazinyl)-1-oxoethyl]amino]phenyl]amino]-phenylmethylene]-2-oxo-6-indolinecarboxylic acid methyl ester

(3Z)-3-[[4-[methyl-[2-(4-methyl-1-piperazinyl)-1-oxoethyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylic acid methyl ester

(Z)-3-[(4-{Methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino}phenylamino)methylene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester

(Z)-methyl 3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

(Z)-methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

(Z)-Methyl 3-((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)-phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

1624587-84-3 [RN]

1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[2-(4-4-[methyl[2-(4-|methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester

656247-17-5 (free base)

928326-83-4?? 656247-17-5

CID 9809715

D10481

https://www.ebi.ac.uk/chembl/compound_reportcard/CHEMBL502835/

Intedanib

Intedanib-d3

KS-1434

methyl (3Z)-2-hydroxy-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-3H-indole-6-carboxylate

methyl (3Z)-2-hydroxy-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]indole-6-carboxylate

methyl (3Z)-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-1H-indole-6-carboxylate

methyl (3Z)-3-[({4-[N-methyl-2-(4-methylpiperazin-1-yl)acetamido]phenyl}amino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate

methyl (3Z)-3-[(4-{methyl[(4-methylpiperazin-1-yl)acetyl]amino}anilino)(phenyl)methylidene]-2-oxo-2,3-dihydro-1H-indole-6-carboxylate

methyl (3Z)-3-[[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]amino]-phenyl-methylene]-2-oxo-indoline-6-carboxylate

methyl (3Z)-3-[[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]phenyl]amino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate

methyl (3Z)-3-[[[4-[methyl-[2-(4-methylpiperazin-1-yl)ethanoyl]amino]phenyl]amino]-phenyl-methylidene]-2-oxo-1H-indole-6-carboxylate

methyl (3Z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenyl-methylene]-2-oxo-indoline-6-carboxylate

methyl (3Z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxylate

Methyl (3z)-3-{[(4-{methyl[(4-Methylpiperazin-1-Yl)acetyl]amino}phenyl)amino](Phenyl)methylidene}-2-Oxo-2,3-Dihydro-1h-Indole-6-Carboxylate

methyl (Z)-3-(((4-(N-methyl-2-(4-methylpiperazin-1-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxylate

methyl(3z)-3-[[4-[methyl-[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1h-indole-6-carboxylate

MFCD11974012

nintédanib

Nintedanib (USAN/INN)

nintedanibum

Ofev (TN)

Ofev®

UNII:G6HRD2P839

UNII-G6HRD2P839

Vargatef®

XIN

нинтеданиб [Russian]

نينتيدانيب [Arabic]

尼达尼布 [Chinese]

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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

9229 [DBID]

BIBF 1120 [DBID]

BIBF-1120 [DBID]

G6HRD2P839 [DBID]

Experimental data
Predicted - ACD/Labs
Predicted - ChemAxon
Predicted - Mcule

Experimental Physico-chemical Properties

Experimental Solubility:

Miscellaneous

Target Organs:

VEGFR inhibitor TargetMol T1777

Chemical Class:

Bio Activity:

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density:	1.3±0.1 g/cm³
Boiling Point:	742.2±60.0 °C at 760 mmHg
Vapour Pressure:	0.0±2.5 mmHg at 25°C
Enthalpy of Vaporization:	108.2±3.0 kJ/mol
Flash Point:	402.7±32.9 °C
Index of Refraction:	1.658
Molar Refractivity:	154.8±0.3 cm³
#H bond acceptors:	9
#H bond donors:	2
#Freely Rotating Bonds:	8
#Rule of 5 Violations:	1

ACD/LogP:	2.59
ACD/LogD (pH 5.5):	0.88
ACD/BCF (pH 5.5):	1.00
ACD/KOC (pH 5.5):	9.48
ACD/LogD (pH 7.4):	2.48
ACD/BCF (pH 7.4):	37.60
ACD/KOC (pH 7.4):	376.90
Polar Surface Area:	94 Å²
Polarizability:	61.4±0.5 10^-24cm³
Surface Tension:	58.0±3.0 dyne/cm
Molar Volume:	420.1±3.0 cm³

Click to predict properties on the Chemicalize site

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Nintedanib

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Target Organs:

Chemical Class:

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