ChemSpider 2D Image | Neuromedin N | C38H63N7O8

Neuromedin N

  • Molecular FormulaC38H63N7O8
  • Average mass745.949 Da
  • Monoisotopic mass745.473816 Da
  • ChemSpider ID8115921
  • defined stereocentres - 8 of 8 defined stereocentres


More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

102577-25-3 [RN]
L-Leucine, L-lysyl-L-isoleucyl-L-prolyl-L-tyrosyl-L-isoleucyl- [ACD/Index Name]
L-Lysyl-L-isoleucyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucin [German] [ACD/IUPAC Name]
L-Lysyl-L-isoleucyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine [ACD/IUPAC Name]
L-Lysyl-L-isoleucyl-L-prolyl-L-tyrosyl-L-isoleucyl-L-leucine [French] [ACD/IUPAC Name]
Neuromedin N [Wiki]
(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-4-methylpentanoic acid
92169-45-4 [RN]
h-lys-ile-pro-tyr-ile-leu-oh
Lys-Ile-Pro-Tyr-Ile-Leu;Neuromedin N (rat, mouse, porcine, canine)
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  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Bio Activity:

      7-TM Receptors Tocris Bioscience 1907
      Dopamine Receptor MedChem Express HY-P0079
      Endogenous neurotensin-like neuropeptide, originally isolated from porcine spinal cord. Binds to neurotensin receptors (IC50 = 16.7 nM for inhibition of [Trp11]-NT binding to rat brain receptors). Reg ulates guinea pig intestinal smooth muscle contraction and produces hypotension in rats. Also induces hypothermia following central administration in rats in vivo. Tocris Bioscience 1907
      Endogenous neurotensin-like neuropeptide, originally isolated from porcine spinal cord. Binds to neurotensin receptors (IC50 = 16.7 nM for inhibition of [Trp11]-NT binding to rat brain receptors). Regulates guinea pig intestinal smooth muscle contraction and produces hypotension in rats. Also induces hypothermia following central administration in rats in vivo. Tocris Bioscience 1907
      GPCR/G protein; Neuronal Signaling; MedChem Express HY-P0079
      Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes.;Target: dopamine D2 receptor;In the concentration range of 1-10 nM, neuromedin N produced a significant concentration-related increase in the Kd values of [3H]L-(-)-N-propylnorapomorphine binding sites in rat neostriatal membranes with a peak action at 10 nM (36% increase versus the control group mean value). The Bmax values were not affected by neuromedin N. Neurotensin at 10 nM induced an increase in the Kd values, which was not affected by a threshold concentration of neuromedin N (0.1 nM). In view of the higher potency of neuromedin N versus neurotensin to modulate neostriatal D2 receptors in contrast to the higher potency of neurotensin versus neuromedin N to bind to the cloned neurotensin receptors, it seems possible that the neuromedin N activated neostriatal neurotensin receptors controlling the D2 receptors represent a distinct subtype of neurotensin receptors. MedChem Express HY-P0079
      Neurotensin Receptors Tocris Bioscience 1907
      Neurotensin-like peptide Tocris Bioscience 1907
      Peptide Receptors Tocris Bioscience 1907

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.2±0.1 g/cm3
Boiling Point: 1071.6±65.0 °C at 760 mmHg
Vapour Pressure: 0.0±0.3 mmHg at 25°C
Enthalpy of Vaporization: 164.5±3.0 kJ/mol
Flash Point: 601.9±34.3 °C
Index of Refraction: 1.551
Molar Refractivity: 200.8±0.3 cm3
#H bond acceptors: 15
#H bond donors: 10
#Freely Rotating Bonds: 22
#Rule of 5 Violations: 3
ACD/LogP: 3.54
ACD/LogD (pH 5.5): -1.76
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): -1.13
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 1.00
Polar Surface Area: 246 Å2
Polarizability: 79.6±0.5 10-24cm3
Surface Tension: 53.3±3.0 dyne/cm
Molar Volume: 629.2±3.0 cm3

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