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Inherent Properties, Identifiers and References
ChemSpider ID: 919348
Empirical Formula: C17H13ClN4
Molecular Weight: 308.7649
Nominal Mass: 308 Da
Average Mass: 308.7649 Da
Monoisotopic Mass: 308.082874 Da
Quick Links: Permalink Similar Isomers
Systematic Name: (E)-2-(1H-benzimidazol-2-yl)-3-[(3-chloro-4-methyl-phenyl)amino]p​rop-2-enenitrile
SMILES: Clc1c(ccc(c1)N\C=C(/C#N)c3nc2ccccc2n3)C
InChI: InChI=1/C17H13ClN4/c1-11-6-7-13(8-14(11)18)20-10-12(9-19)17-21-15​-4-2-3-5-16(15)22-17/h2-8,10,20H,1H3,(H,21,22)/b12-10+
InChIKey: UMEQYLMGWKIOSF-ZRDIBKRKBV
(Details...) Original Reference(s) Filter
Data Source External ID(s)
ASINEX Substance Vendors BAS 05163985
Directory of Useful Decoys N/A
DiscoveryGate 1078115
PubChem 1078115
Ryan Scientific Substance Vendors BAS 05163985
ZINC Substance Vendors ZINC00790677
(Details...) Names and Synonyms

Validated by Experts, Validated by Users, Non-Validated, Removed by Users, Redirected by Users, Redirect Approved by Experts

(E)-2-(1H​-Benzoimi​dazol-2-y​l)-3-(3-c​hloro-4-m​ethyl-phe​nylamino)​-acryloni​trile

(Details...) Database ID(s)

Validated by Experts, Validated by Users, Non-Validated, Removed by Users, Redirected by Users, Redirect Approved by Experts

BAS 05163​985

ZINC00790​677

(Details...) Predicted Properties
LogP: ACD/LogP: 4.35
XLogP: 4.00
# of Rule of 5 Violations: 0
ACD/LogD (pH 5.5): 4.23 ACD/LogD (pH 7.4): 4.35
ACD/BCF (pH 5.5): 914.53 ACD/BCF (pH 7.4): 1182.41
ACD/KOC (pH 5.5): 4254.96 ACD/KOC (pH 7.4): 5501.33
#H bond acceptors: 4 #H bond donors: 2
#Freely Rotating Bonds: 3 Polar Surface Area: 44.85 Å2
Index of Refraction: 1.732 Molar Refractivity: 89.96 cm3
Molar Volume: 224.8 cm3 Polarizability: 35.66 10-24cm3
Surface Tension: 67.3 dyne/cm Density: 1.372 g/cm3
Flash Point: 261 °C Enthalpy of Vaporization: 77.82 kJ/mol
Boiling Point: 508 °C at 760 mmHg Vapour Pressure: 1.93E-10 mmHg at 25°C
            
 Log Octanol-Water Partition Coef (SRC):
    Log Kow (KOWWIN v1.67 estimate) =  3.12

 Boiling Pt, Melting Pt, Vapor Pressure Estimations (MPBPWIN v1.42):
    Boiling Pt (deg C):  551.57  (Adapted Stein & Brown method)
    Melting Pt (deg C):  236.69  (Mean or Weighted MP)
    VP(mm Hg,25 deg C):  6.9E-012  (Modified Grain method)
    Subcooled liquid VP: 1.33E-009 mm Hg (25 deg C, Mod-Grain method)

 Water Solubility Estimate from Log Kow (WSKOW v1.41):
    Water Solubility at 25 deg C (mg/L):  12.86
       log Kow used: 3.12 (estimated)
       no-melting pt equation used

 Water Sol Estimate from Fragments:
    Wat Sol (v1.01 est) =  55.468 mg/L

 ECOSAR Class Program (ECOSAR v0.99h):
    Class(es) found:
       Allylic/Vinyl Nitriles
       Imidazoles

 Henrys Law Constant (25 deg C) [HENRYWIN v3.10]:
   Bond Method :   4.07E-014  atm-m3/mole
   Group Method:   Incomplete
 Henrys LC [VP/WSol estimate using EPI values]:  2.180E-013 atm-m3/mole

 Log Octanol-Air Partition Coefficient (25 deg C) [KOAWIN v1.10]:
  Log Kow used:  3.12  (KowWin est)
  Log Kaw used:  -11.779  (HenryWin est)
      Log Koa (KOAWIN v1.10 estimate):  14.899
      Log Koa (experimental database):  None

 Probability of Rapid Biodegradation (BIOWIN v4.10):
   Biowin1 (Linear Model)         :   0.5460
   Biowin2 (Non-Linear Model)     :   0.4807
 Expert Survey Biodegradation Results:
   Biowin3 (Ultimate Survey Model):   2.0180  (months      )
   Biowin4 (Primary Survey Model) :   2.9948  (weeks       )
 MITI Biodegradation Probability:
   Biowin5 (MITI Linear Model)    :  -0.1811
   Biowin6 (MITI Non-Linear Model):   0.0016
 Anaerobic Biodegradation Probability:
   Biowin7 (Anaerobic Linear Model): -0.9573
 Ready Biodegradability Prediction:   NO

Hydrocarbon Biodegradation (BioHCwin v1.01):
    Structure incompatible with current estimation method!

 Sorption to aerosols (25 Dec C)[AEROWIN v1.00]:
  Vapor pressure (liquid/subcooled):  1.77E-007 Pa (1.33E-009 mm Hg)
  Log Koa (Koawin est  ): 14.899
   Kp (particle/gas partition coef. (m3/ug)):
       Mackay model           :  16.9 
       Octanol/air (Koa) model:  195 
   Fraction sorbed to airborne particulates (phi):
       Junge-Pankow model     :  0.998 
       Mackay model           :  0.999 
       Octanol/air (Koa) model:  1 

 Atmospheric Oxidation (25 deg C) [AopWin v1.92]:
   Hydroxyl Radicals Reaction:
      OVERALL OH Rate Constant =  79.1098 E-12 cm3/molecule-sec
      Half-Life =     0.135 Days (12-hr day; 1.5E6 OH/cm3)
      Half-Life =     1.622 Hrs
   Ozone Reaction:
      OVERALL Ozone Rate Constant =     0.105000 E-17 cm3/molecule-sec
      Half-Life =    10.914 Days (at 7E11 mol/cm3)
   Fraction sorbed to airborne particulates (phi): 0.999 (Junge,Mackay)
    Note: the sorbed fraction may be resistant to atmospheric oxidation

 Soil Adsorption Coefficient (PCKOCWIN v1.66):
      Koc    :  5103
      Log Koc:  3.708 

 Aqueous Base/Acid-Catalyzed Hydrolysis (25 deg C) [HYDROWIN v1.67]:
    Rate constants can NOT be estimated for this structure!

 Bioaccumulation Estimates from Log Kow (BCFWIN v2.17):
   Log BCF from regression-based method = 1.701 (BCF = 50.29)
       log Kow used: 3.12 (estimated)

 Volatilization from Water:
    Henry LC:  4.07E-014 atm-m3/mole  (estimated by Bond SAR Method)
    Half-Life from Model River: 2.528E+010  hours   (1.053E+009 days)
    Half-Life from Model Lake : 2.758E+011  hours   (1.149E+010 days)

 Removal In Wastewater Treatment:
    Total removal:               6.85  percent
    Total biodegradation:        0.13  percent
    Total sludge adsorption:     6.72  percent
    Total to Air:                0.00  percent
      (using 10000 hr Bio P,A,S)

 Level III Fugacity Model:
           Mass Amount    Half-Life    Emissions
            (percent)        (hr)       (kg/hr)
   Air       0.000214        3.21         1000       
   Water     10.2            1.44e+003    1000       
   Soil      89.4            2.88e+003    1000       
   Sediment  0.341           1.3e+004     0          
     Persistence Time: 2.72e+003 hr