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ChemSpider 2D Image | 9222 | C26H31FN7O6P

9222

  • Molecular FormulaC26H31FN7O6P
  • Average mass587.540 Da
  • Monoisotopic mass587.205750 Da
  • ChemSpider ID9672789

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

16XC2U7W8N
1H-Pyrazole-3-acetamide, 5-[[7-[3-[ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)- [ACD/Index Name]
1H-pyrazole-5-acetamide, 3-[[7-[3-[ethyl[2-(phosphonooxy)ethyl]amino]propoxy]-4-quinazolinyl]amino]-N-(3-fluorophenyl)-
2-((3-((4-((5-(2-((3-fluorophenyl)amino)-2-oxoethyl)-1H-pyrazol-3-yl)amino)quinazolin-7-yl)oxy)propyl)(ethyl)amino)ethyl dihydrogen phosphate
2-{Ethyl[3-({4-[(3-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-5-yl)amino]-7-quinazolinyl}oxy)propyl]amino}ethyl dihydrogen phosphate [ACD/IUPAC Name]
2-{Ethyl[3-({4-[(3-{2-[(3-fluorphenyl)amino]-2-oxoethyl}-1H-pyrazol-5-yl)amino]-7-chinazolinyl}oxy)propyl]amino}ethyldihydrogenphosphat [German] [ACD/IUPAC Name]
2-{ethyl[3-({4-[(5-{2-[(3-fluorophenyl)amino]-2-oxoethyl}-1H-pyrazol-3-yl)amino]quinazolin-7-yl}oxy)propyl]amino}ethyl dihydrogen phosphate
722543-31-9 [RN]
9222
AZD-1152
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

Kinome_3324 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Bio Activity:

      Aurora Kinase MedChem Express HY-10127
      AZD1152 (barasertib), pro-drug of barasertib-hQPA(HY-10126), is a selective Aurora B kinase inhibitor, AZD1152 inhibited the proliferation various types of human leukemia cells with an IC50 ranging f rom 3 nM to 40 nM. MedChem Express
      AZD1152 (barasertib), pro-drug of barasertib-hQPA(HY-10126), is a selective Aurora B kinase inhibitor, AZD1152 inhibited the proliferation various types of human leukemia cells with an IC50 ranging from 3 nM to 40 nM.; IC50 value: 3-40 nM (HL-60, NB4, MOLM13; PALL-2; MV4-11; EOL-1; K562 cell) [1]; Target: Aurora B kinase; in vitro: AZD1152, a highly selective inhibitor of Aurora B kinase, on various types of human leukemia cells. MedChem Express HY-10127
      AZD1152 (barasertib), pro-drug of barasertib-hQPA(HY-10126), is a selective Aurora B kinase inhibitor, AZD1152 inhibited the proliferation various types of human leukemia cells with an IC50 ranging from 3 nM to 40 nM.;IC50 value: 3-40 nM (HL-60, NB4, MOLM13; PALL-2; MV4-11; EOL-1; K562 cell) [1];Target: Aurora B kinase;In vitro: AZD1152, a highly selective inhibitor of Aurora B kinase, on various types of human leukemia cells. AZD1152 inhibited the proliferation of AML lines (HL-60, NB4, MOLM13), ALL line (PALL-2), biphenotypic leukemia (MV4-11), acute eosinophilic leukemia (EOL-1), and the blast crisis of chronic myeloid leukemia K562 cells with an IC50 ranging from 3 nM to 40 nM, as measured by thymidine uptake on day 2 of culture [1]. The selective Aurora B inhibitor AZD1152-induced apoptotic death in myeloma cell lines at nanomolar concentrations, with a cell cycle phenotype consistent with that reported previously for Aurora B inhibition [3]. AZD1152 exerted antiproliferative MedChem Express HY-10127
      Cell Cycle/DNA Damage MedChem Express HY-10127
      Cell Cycle/DNA Damage; MedChem Express HY-10127

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.5±0.1 g/cm3
Boiling Point:
Vapour Pressure:
Enthalpy of Vaporization:
Flash Point:
Index of Refraction: 1.675
Molar Refractivity: 150.8±0.3 cm3
#H bond acceptors: 13
#H bond donors: 5
#Freely Rotating Bonds: 15
#Rule of 5 Violations: 3
ACD/LogP: 1.71
ACD/LogD (pH 5.5): -1.74
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): -2.26
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 1.00
Polar Surface Area: 185 Å2
Polarizability: 59.8±0.5 10-24cm3
Surface Tension: 73.6±3.0 dyne/cm
Molar Volume: 401.4±3.0 cm3

Click to predict properties on the Chemicalize site






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