ChemSpider 2D Image | Pazopanib Hydrochloride | C21H24ClN7O2S

Pazopanib Hydrochloride

  • Molecular FormulaC21H24ClN7O2S
  • Average mass473.979 Da
  • Monoisotopic mass473.140076 Da
  • ChemSpider ID9700526

More details:






Validated by Experts, Validated by Users, Non-Validated, Removed by Users

5-({4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]-2-pyrimidinyl}amino)-2-methylbenzenesulfonamide hydrochloride (1:1) [ACD/IUPAC Name]
5-({4-[(2,3-Diméthyl-2H-indazol-6-yl)(méthyl)amino]-2-pyrimidinyl}amino)-2-méthylbenzènesulfonamide, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
5-({4-[(2,3-Dimethyl-2H-indazol-6-yl)(methyl)amino]-2-pyrimidinyl}amino)-2-methylbenzolsulfonamidhydrochlorid (1:1) [German] [ACD/IUPAC Name]
635702-64-6 [RN]
Benzenesulfonamide, 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-, hydrochloride (1:1) [ACD/Index Name]
GW786034B
GW-786034B
Pazopanib Hydrochloride [USAN]
Votrient [Trade name]
[635702-64-6]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

33Y9ANM545 [DBID]
GW-786034 [DBID]
UNII:33Y9ANM545 [DBID]
UNII-33Y9ANM545 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Safety:

      5 Axon Medchem 1420
      H303;H313;H317;H333;H334;H335;H373 Axon Medchem 1420
      no pictogram Axon Medchem 1420
      P101;P102;P103;P260;P262;P263;P264;P270;P280;P304;P312;P340 Axon Medchem 1420
      Warning Axon Medchem 1420
    • Chemical Class:

      A hydrochloride salt prepared from equimolar amounts of pazopanib and hydrochloric acid. Used for treatment of kidney cancer. ChEBI CHEBI:71217
    • Bio Activity:

      Pazopanib Hcl (GW-786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively. MedChem Express
      Pazopanib Hcl (GW-786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.; IC50 value: 10/30/47/84/74/140/146 nM (pan VEGFR1/2/3/PDGFR/FGFR/c-Kit/c-Fms) [1]; Target: VEGFR/PDGFR/VEGFR/CSF1R; in vitro: Pazopanib potently inhibits VEGF-induced phosphorylation of VEGFR2 in HUVEC cells with IC50 of 8 nM [1]. MedChem Express HY-12009
      PDGFR MedChem Express HY-12009
      PDGFR VEGFR MedChem Express HY-12009
      Protein Tyrosine Kinase/RTK MedChem Express HY-12009
      Protein Tyrosine Kinase/RTK; MedChem Express HY-12009

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

No predicted properties have been calculated for this compound.

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