ChemSpider 2D Image | Fingolimod hydrochloride | C19H34ClNO2

Fingolimod hydrochloride

  • Molecular FormulaC19H34ClNO2
  • Average mass343.932 Da
  • Monoisotopic mass343.227814 Da
  • ChemSpider ID97086

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

Fingolimod hydrochloride [USAN]
1,3-Propanediol, 2-amino-2-[2-(4-octylphenyl)ethyl]-, hydrochloride (1:1) [ACD/Index Name]
162359-56-0 [RN]
2-amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol hydrochloride
2-Amino-2-(4-octylphenethyl)propane-1,3-diol hydrochloride
2-amino-2-[2-(4-octylphenyl) ethyl]-1,3-propanediol hydrochloride
2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propandiolhydrochlorid
2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propandiolhydrochlorid (1:1) [German] [ACD/IUPAC Name]
2-Amino-2-[2-(4-octylphényl)éthyl]-1,3-propanediol chlorhydrate
2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol hydrochloride
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

FTY720 [DBID]
FTY720 hydrochloride [DBID]
FTY-720A [DBID]
FTY 720 [DBID]
FTY-720 [DBID]
  • References
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      S1P Receptor antagonist TargetMol T2539

    • Chemical Class:

      The hydrochloride salt of 2-amino-2-[2-(4-octylphenyl) ethyl]-1,3-propanediol (fingolimod). ChEBI https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:63112, CHEBI:63112

    • Bio Activity:

      <p>Cell permeable immunosuppressor which displays lymphocyte sequestration properties. It is a sphingosine 1-phosphate (S1P) receptor modulator (S1P1, S1P3, S1P4, and S1P5) when phosphorylated by sphingosine kinase.</p> <p>It also enhances activity of Sphingosine transporter Abcb1 and leukotriene C4 transporter Abcc1 and inhibits Cytosolic phospholipase A2 independent of sphingosine 1-phosphate receptors.</p <p>It induces autophagy and apoptosis and shows immunosuppresant actions. Also suppresses the development of the multiple sclreosis EAE model.</p> <p>Recently investigated as part of COVID-19 compound repurposing.</p> Hello Bio HB3899
      7-TM Receptors Tocris Bioscience 6176
      Biochemicals & small molecules/Agonists & activators Hello Bio HB3899
      Cell permeable immunosuppressor displaying lymphocyte sequestration properties and used for treatment in multiple sclerosis. Potent sphingosine 1-phosphate (S1P) receptor (S1P1, S1P3, S1P4, and S1P5) agonist when phosphorylated by sphingosine kinase. Sphingosine transporter Abcb1 and leukotriene C4 transporter Abcc1 activity enhancer. Cytosolic phospholipase A2 inhibitor, independent of sphingosine 1-phosphate receptors. Autophagy inducer. Apoptosis inducer. Hello Bio HB3899
      Fingolimod Hcl (FTY720) is a S1P antagonist with IC50 of 0.033 nM.; IC50 value: 0.033 nM; Target: S1P; in vitro: The inhibitory effect of S1P is revered by various concentrations of FTY720, with IC50 effect of 173 nM. MedChem Express HY-12005
      GPCR/G protein MedChem Express HY-12005
      GPCR/G Protein TargetMol T2539
      GPCR/G protein; MedChem Express HY-12005
      LPL Receptor MedChem Express HY-12005
      Potent S1P receptor agonist; also immunosuppresent Tocris Bioscience 6176
      Potent S1P receptor agonist; also immunosuppressant Tocris Bioscience 6176
      Potent sphingosine 1-phosphate (S1P) receptor (S1P1, S1P3, S1P4, and S1P5) agonist Hello Bio HB3899
      Receptors & Transporters/G protein coupled receptors/Sphingosine-1-phosphate Hello Bio HB3899
      S1P receptor TargetMol T2539
      S1P receptor agonist; undergoes phosphorylation by sphingosine kinase 2, which then binds S1P1,3,4 and 5 receptors (EC50 values are 0.3 - 0.6 nM for S1P1, 4 and 5 and ~3 nM for S1P3). Immunosuppresant; sequesters lymphocytes in lymph nodes, reducing autoimmune response. Suppresses the development of EAE (an in vivo model of MS). Orally bioavailable and blood-brain barrier permeable. Tocris Bioscience 6176
      S1P receptor agonist; undergoes phosphorylation by sphingosine kinase 2, which then binds S1P1,3,4 and 5 receptors (EC50 values are 0.3 - 0.6 nM for S1P1, 4 and 5 and ~3 nM for S1P3). Immunosuppresent; sequesters lymphocytes in lymph nodes, reducing autoimmune response. Suppresses the development of EAE (an in vivo model of MS). Orally bioavailable and blood-brain barrier permeable. Tocris Bioscience 6176
      Sphingosine-1-phosphate Receptors Tocris Bioscience 6176

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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