PLANNED MAINTENANCE

There will be scheduled maintenance work beginning on Wednesday 26th February 2020 from 11:00 AM through to 12.00 PM (GMT).

During this time, you may not be able to log into ChemSpider. We apologise for any inconvenience this might cause and thank you for your patience.


ChemSpider 2D Image | Fostamatinib | C23H26FN6O9P

Fostamatinib

  • Molecular FormulaC23H26FN6O9P
  • Average mass580.459 Da
  • Monoisotopic mass580.148315 Da
  • ChemSpider ID9846198

More details:



Featured data source



Validated by Experts, Validated by Users, Non-Validated, Removed by Users

[6-({5-Fluor-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl}amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl]methyldihydrogenphosphat [German] [ACD/IUPAC Name]
[6-({5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl}amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate [ACD/IUPAC Name]
2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]- [ACD/Index Name]
901119-35-5 [RN]
9022
Dihydrogénophosphate de [6-({5-fluoro-2-[(3,4,5-triméthoxyphényl)amino]-4-pyrimidinyl}amino)-2,2-diméthyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl]méthyle [French] [ACD/IUPAC Name]
fostamatinib [French] [INN]
fostamatinib [Spanish] [INN]
fostamatinibum [Latin] [INN]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

R 788 [DBID]
R788 [DBID]
R-788 [DBID]
R7935788 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Bio Activity:

      Protein Tyrosine Kinase/RTK MedChem Express HY-13038A
      Protein Tyrosine Kinase/RTK; MedChem Express HY-13038A
      R788 (Fostamatinib), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM. MedChem Express
      R788 (Fostamatinib), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.; IC50 Value: 41 nM [1]; Target: Syk; in vitro: R788 is a methylene phosphate prodrug of R406, which can be rapidly converted to R406 in vivo. MedChem Express HY-13038A
      Syk MedChem Express HY-13038A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module

Density: 1.5±0.1 g/cm3
Boiling Point: 814.2±75.0 °C at 760 mmHg
Vapour Pressure: 0.0±3.1 mmHg at 25°C
Enthalpy of Vaporization: 124.1±3.0 kJ/mol
Flash Point: 446.2±37.1 °C
Index of Refraction: 1.629
Molar Refractivity: 137.9±0.3 cm3
#H bond acceptors: 15
#H bond donors: 4
#Freely Rotating Bonds: 10
#Rule of 5 Violations: 2
ACD/LogP: 2.12
ACD/LogD (pH 5.5): -2.18
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): -3.10
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 1.00
Polar Surface Area: 197 Å2
Polarizability: 54.7±0.5 10-24cm3
Surface Tension: 68.8±3.0 dyne/cm
Molar Volume: 387.8±3.0 cm3

Click to predict properties on the Chemicalize site






Advertisement