ChemSpider 2D Image | Fostamatinib | C23H26FN6O9P

Fostamatinib

  • Molecular FormulaC23H26FN6O9P
  • Average mass580.459 Da
  • Monoisotopic mass580.148315 Da
  • ChemSpider ID9846198

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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

[6-({5-Fluor-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl}amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl]methyldihydrogenphosphat [German] [ACD/IUPAC Name]
[6-({5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl}amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate [ACD/IUPAC Name]
{[6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-3-oxo-2H,3H,4H-pyrido[3,2-b][1,4]oxazin-4-yl]methoxy}phosphonic acid
2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one, 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]- [ACD/Index Name]
901119-35-5 [RN]
Dihydrogénophosphate de [6-({5-fluoro-2-[(3,4,5-triméthoxyphényl)amino]-4-pyrimidinyl}amino)-2,2-diméthyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl]méthyle [French] [ACD/IUPAC Name]
fostamatinib [French] [INN]
fostamatinib [Spanish] [INN]
fostamatinibum [Latin] [INN]
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

9022 [DBID]
R 788 [DBID]
R788 [DBID]
R-788 [DBID]
R7935788 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous
    • Bio Activity:

      Protein Tyrosine Kinase/RTK MedChem Express HY-13038A
      Protein Tyrosine Kinase/RTK; MedChem Express HY-13038A
      R788 (Fostamatinib), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM. MedChem Express
      R788 (Fostamatinib), a prodrug of the active metabolite R406, is a potent Syk inhibitor with IC50 of 41 nM.; IC50 Value: 41 nM [1]; Target: Syk; in vitro: R788 is a methylene phosphate prodrug of R406, which can be rapidly converted to R406 in vivo. MedChem Express HY-13038A
      Syk MedChem Express HY-13038A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.5±0.1 g/cm3
Boiling Point: 814.2±75.0 °C at 760 mmHg
Vapour Pressure: 0.0±3.1 mmHg at 25°C
Enthalpy of Vaporization: 124.1±3.0 kJ/mol
Flash Point: 446.2±37.1 °C
Index of Refraction: 1.629
Molar Refractivity: 137.9±0.3 cm3
#H bond acceptors: 15
#H bond donors: 4
#Freely Rotating Bonds: 10
#Rule of 5 Violations: 2
ACD/LogP: 2.12
ACD/LogD (pH 5.5): -2.18
ACD/BCF (pH 5.5): 1.00
ACD/KOC (pH 5.5): 1.00
ACD/LogD (pH 7.4): -3.10
ACD/BCF (pH 7.4): 1.00
ACD/KOC (pH 7.4): 1.00
Polar Surface Area: 197 Å2
Polarizability: 54.7±0.5 10-24cm3
Surface Tension: 68.8±3.0 dyne/cm
Molar Volume: 387.8±3.0 cm3

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