ChemSpider 2D Image | Nebivolol hydrochloride | C22H26ClF2NO4

Nebivolol hydrochloride

  • Molecular FormulaC22H26ClF2NO4
  • Average mass441.896 Da
  • Monoisotopic mass441.151855 Da
  • ChemSpider ID9986920

  • defined stereocentres - 4 of 4 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(1R)-1-[(2R)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-{[(2R)-2-[(2S)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-hydroxyethyl]amino}ethan-1-ol hydrochloride
(2R)-2-[(2R)-6-Fluor-3,4-dihydro-2H-chromen-2-yl]-N-{(2R)-2-[(2S)-6-fluor-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl}-2-hydroxyethanaminiumchlorid [German] [ACD/IUPAC Name]
(2R)-2-[(2R)-6-Fluoro-3,4-dihydro-2H-chromen-2-yl]-N-{(2R)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl}-2-hydroxyethanaminium chloride [ACD/IUPAC Name]
(S,R,R,R)-nebivolol hydrochloride
152520-56-4 [RN]
2H-1-Benzopyran-2-ethanaminium, 6-fluoro-N-[(2R)-2-[(2R)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-hydroxyethyl]-3,4-dihydro-β-hydroxy-, chloride, (βR,2S)- (1:1) [ACD/Index Name]
Chlorure de (2R)-2-[(2R)-6-fluoro-3,4-dihydro-2H-chromén-2-yl]-N-{(2R)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromén-2-yl]-2-hydroxyéthyl}-2-hydroxyéthanaminium [French] [ACD/IUPAC Name]
Nebivolol hydrochloride
(1R)-1-[(2R)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-[[(2R)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]amino]ethanol
(1R)-1-[(2R)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-[[(2R)-2-[(2S)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl]amino]ethanol;hydrochloride
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

JGS34J7L9I [DBID]
UNII:JGS34J7L9I [DBID]
CGS 20267 | [DBID]
R-67145 [DBID]
UNII-JGS34J7L9I [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      A hydrochloride obtained by reaction of (<stereo>S</stereo>,<stereo>R</stereo>,<stereo>R</stereo>,<stereo>R</stereo>)-nebivolol with one equivalent of hydrochloric acid. ChEBI CHEBI:132913
      A hydrochloride obtained by reaction of (S,R,R,R)-nebivolol with one equivalent of hydrochloric acid. ChEBI https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:132913, CHEBI:132913

    • Bio Activity:

      7-TM Receptors Tocris Bioscience 3517
      Adrenergic Beta-1 Receptors Tocris Bioscience 3517
      Adrenergic Receptors Tocris Bioscience 3517
      Highly selective ?1-adrenoceptor antagonist Tocris Bioscience 3517
      Highly selective ?1-adrenoceptor antagonist (Ki values are 0.88, 20, 44, 700, 1160, 2400 and 4000 nM at ?1, 5-HT1A, ?2, 5-HT2, ?1, H1 and D2 receptors respectively). Induces vasodilation via a nitric oxide- and cGMP-dependent mechanism (EC50 = 11.36 ?M in renal arteries) and displays antihypertensive activity in vivo. GRK/? -arrestin biased agonist at the ?2 adrenoceptor. Tocris Bioscience 3517
      Highly selective ?1-adrenoceptor antagonist (Ki values are 0.88, 20, 44, 700, 1160, 2400 and 4000 nM at ?1, 5-HT1A, ?2, 5-HT2, ?1, H1 and D2 receptors respectively). Induces vasodilation via a nitric oxide- and cGMP-dependent mechanism (EC50 = 11.36 ?M in renal arteries) and displays antihypertensive activity in vivo. GRK/? -arrestin biased agonist at the ?2 adrenoceptor. Tocris Bioscience 3517
      Highly selective beta1-adrenoceptor antagonist Tocris Bioscience 3517
      Highly selective beta1-adrenoceptor antagonist (Ki values are 0.88, 20, 44, 700, 1160, 2400 and 4000 nM at beta1, 5-HT1A, beta2, 5-HT2, alpha1, H1 and D2 receptors respectively). Induces vasodilation via a nitric oxide- and cGMP-dependent mechanism (EC50 = 11.36 muM in renal arteries) and displays antihypertensive activity in vivo. GRK/beta -arrestin biased agonist at the beta2 adrenoceptor. Tocris Bioscience 3517

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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