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25/11/2020 04:44:46
Normal
Acknowledged
When I build this structure as represented in my computational chemistry program it determines the chirality at the 4 chiral atoms as R,R,R and R not as R,S,R and R as is given in the systematic name. Why is this? If I convert the R to an S in the program the ribose OH's end up trans to each other. Is this an error in the naming? Thanks for your advise.
03/02/2021 10:22:18
I believe there must be an error in your software. I've checked multiple sources, generated the stereochem with multiple tools and manually assigned it myself – 2R,3S,4R,5R is correct for the structure shown. Thanks, Mark

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