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Search term: GMMVVJJBQBYMNZ-UHFFFAOYAT
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Inherent Properties, Identifiers and References
ChemSpider ID: 79114
Empirical Formula: C10H7ClFN
Molecular Weight: 195.6207
Nominal Mass: 195 Da
Average Mass: 195.6207 Da
Monoisotopic Mass: 195.025105 Da
Systematic Name: 4-chloro-6-fluoro-2-methyl-quinoline
SMILES: Fc1ccc2nc(cc(Cl)c2c1)C
InChI: InChI=1/C10H7ClFN/c1-6-4-9(11)8-5-7(12)2-3-10(8)13-6/h2-5H,1H3
InChIKey: GMMVVJJBQBYMNZ-UHFFFAOYAT
Std. InChI: InChI=1S/C10H7ClFN/c1-6-4-9(11)8-5-7(12)2-3-10(8)13-6/h2-5H,1H3
Std. InChIKey: GMMVVJJBQBYMNZ-UHFFFAOYSA-N
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Names and Synonyms

Validated by Experts, Validated by Users, Non-Validated, Removed by Users, Redirected by Users, Redirect Approved by Experts

4-Chloro-​6-fluoro-​2-methylq​uinoline

quinoline​, 4-chlor​o-6-fluor​o-2-methy​l-

18529-01-6 [RN]

242-403-6 [EINECS/ELINCS]

4-Chloro-​6-fluoro-​2-methyl-​quinoline

4-Chloro-​6-fluoroq​uinaldine

Chloroflu​oromethyl​quinoline

MFCD00272​332

Database ID(s)

Validated by Experts, Validated by Users, Non-Validated, Removed by Users, Redirected by Users, Redirect Approved by Experts

ACD/LogP: 3.29 # of Rule of 5 Violations: 0
ACD/LogD (pH 5.5): 3.28 ACD/LogD (pH 7.4): 3.29
ACD/BCF (pH 5.5): 183.71 ACD/BCF (pH 7.4): 186.6
ACD/KOC (pH 5.5): 1446.47 ACD/KOC (pH 7.4): 1469.29
#H bond acceptors: 1 #H bond donors: 0
#Freely Rotating Bonds: 0 Polar Surface Area: 12.89 Å2
Index of Refraction: 1.612 Molar Refractivity: 51.9 cm3
Molar Volume: 149.2 cm3 Polarizability: 20.57 10-24cm3
Surface Tension: 44.7 dyne/cm Density: 1.311 g/cm3
Flash Point: 117 °C Enthalpy of Vaporization: 48.75 kJ/mol
Boiling Point: 269.9 °C at 760 mmHg Vapour Pressure: 0.0117 mmHg at 25°C
            
 Log Octanol-Water Partition Coef (SRC):
    Log Kow (KOWWIN v1.67 estimate) =  3.53

 Boiling Pt, Melting Pt, Vapor Pressure Estimations (MPBPWIN v1.42):
    Boiling Pt (deg C):  280.45  (Adapted Stein & Brown method)
    Melting Pt (deg C):  76.07  (Mean or Weighted MP)
    VP(mm Hg,25 deg C):  0.00179  (Modified Grain method)
    Subcooled liquid VP: 0.00548 mm Hg (25 deg C, Mod-Grain method)

 Water Solubility Estimate from Log Kow (WSKOW v1.41):
    Water Solubility at 25 deg C (mg/L):  44.11
       log Kow used: 3.53 (estimated)
       no-melting pt equation used

 Water Sol Estimate from Fragments:
    Wat Sol (v1.01 est) =  571.13 mg/L

 ECOSAR Class Program (ECOSAR v0.99h):
    Class(es) found:
       Neutral Organics

 Henrys Law Constant (25 deg C) [HENRYWIN v3.10]:
   Bond Method :   6.57E-007  atm-m3/mole
   Group Method:   5.11E-006  atm-m3/mole
 Henrys LC [VP/WSol estimate using EPI values]:  1.045E-005 atm-m3/mole

 Log Octanol-Air Partition Coefficient (25 deg C) [KOAWIN v1.10]:
  Log Kow used:  3.53  (KowWin est)
  Log Kaw used:  -4.571  (HenryWin est)
      Log Koa (KOAWIN v1.10 estimate):  8.101
      Log Koa (experimental database):  None

 Probability of Rapid Biodegradation (BIOWIN v4.10):
   Biowin1 (Linear Model)         :  -0.2833
   Biowin2 (Non-Linear Model)     :   0.0000
 Expert Survey Biodegradation Results:
   Biowin3 (Ultimate Survey Model):   2.0785  (months      )
   Biowin4 (Primary Survey Model) :   3.3451  (days-weeks  )
 MITI Biodegradation Probability:
   Biowin5 (MITI Linear Model)    :   0.2280
   Biowin6 (MITI Non-Linear Model):   0.0014
 Anaerobic Biodegradation Probability:
   Biowin7 (Anaerobic Linear Model): -0.3197
 Ready Biodegradability Prediction:   NO

Hydrocarbon Biodegradation (BioHCwin v1.01):
    Structure incompatible with current estimation method!

 Sorption to aerosols (25 Dec C)[AEROWIN v1.00]:
  Vapor pressure (liquid/subcooled):  0.731 Pa (0.00548 mm Hg)
  Log Koa (Koawin est  ): 8.101
   Kp (particle/gas partition coef. (m3/ug)):
       Mackay model           :  4.11E-006 
       Octanol/air (Koa) model:  3.1E-005 
   Fraction sorbed to airborne particulates (phi):
       Junge-Pankow model     :  0.000148 
       Mackay model           :  0.000328 
       Octanol/air (Koa) model:  0.00247 

 Atmospheric Oxidation (25 deg C) [AopWin v1.92]:
   Hydroxyl Radicals Reaction:
      OVERALL OH Rate Constant =   6.2512 E-12 cm3/molecule-sec
      Half-Life =     1.711 Days (12-hr day; 1.5E6 OH/cm3)
      Half-Life =    20.532 Hrs
   Ozone Reaction:
      No Ozone Reaction Estimation
   Fraction sorbed to airborne particulates (phi): 0.000238 (Junge,Mackay)
    Note: the sorbed fraction may be resistant to atmospheric oxidation

 Soil Adsorption Coefficient (PCKOCWIN v1.66):
      Koc    :  7968
      Log Koc:  3.901 

 Aqueous Base/Acid-Catalyzed Hydrolysis (25 deg C) [HYDROWIN v1.67]:
    Rate constants can NOT be estimated for this structure!

 Bioaccumulation Estimates from Log Kow (BCFWIN v2.17):
   Log BCF from regression-based method = 2.022 (BCF = 105.1)
       log Kow used: 3.53 (estimated)

 Volatilization from Water:
    Henry LC:  5.11E-006 atm-m3/mole  (estimated by Group SAR Method)
    Half-Life from Model River:      161.7  hours   (6.737 days)
    Half-Life from Model Lake :       1881  hours   (78.38 days)

 Removal In Wastewater Treatment:
    Total removal:              13.96  percent
    Total biodegradation:        0.19  percent
    Total sludge adsorption:    13.52  percent
    Total to Air:                0.25  percent
      (using 10000 hr Bio P,A,S)

 Level III Fugacity Model:
           Mass Amount    Half-Life    Emissions
            (percent)        (hr)       (kg/hr)
   Air       0.77            41.1         1000       
   Water     14.1            1.44e+003    1000       
   Soil      83.9            2.88e+003    1000       
   Sediment  1.31            1.3e+004     0          
     Persistence Time: 1.62e+003 hr