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Search term: VCLIYGCIMKDQPK-OVCLIPMQBJ
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Inherent Properties, Identifiers and References
ChemSpider ID: 4656302
Empirical Formula: C21H10Cl3N3S
Molecular Weight: 442.7482
Nominal Mass: 441 Da
Average Mass: 442.7482 Da
Monoisotopic Mass: 440.9661 Da
Systematic Name: (E)-3-(2-chloro-3-quinolyl)-2-[4-(3,4-dichlorophenyl)thiazol-2-yl​]prop-2-enenitrile
SMILES: Clc4ccc(c1nc(sc1)C(\C#N)=C\c2c(Cl)nc3c(c2)cccc3)cc4Cl
InChI: InChI=1/C21H10Cl3N3S/c22-16-6-5-13(9-17(16)23)19-11-28-21(27-19)1​5(10-25)8-14-7-12-3-1-2-4-18(12)26-20(14)24/h1-9,11H/b15-8+
InChIKey: VCLIYGCIMKDQPK-OVCLIPMQBJ
Std. InChI: InChI=1S/C21H10Cl3N3S/c22-16-6-5-13(9-17(16)23)19-11-28-21(27-19)​15(10-25)8-14-7-12-3-1-2-4-18(12)26-20(14)24/h1-9,11H/b15-8+
Std. InChIKey: VCLIYGCIMKDQPK-OVCLIPMQSA-N
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3-(2-chlo​ro-3-quin​olinyl)-2​-[4-(3,4-​dichlorop​henyl)-1,​3-thiazol​-2-yl]acr​ylonitrile

ACD/LogP: 6.74 # of Rule of 5 Violations: 1
ACD/LogD (pH 5.5): 6.74 ACD/LogD (pH 7.4): 6.74
ACD/BCF (pH 5.5): 77791.06 ACD/BCF (pH 7.4): 77791.15
ACD/KOC (pH 5.5): 110282.64 ACD/KOC (pH 7.4): 110282.77
#H bond acceptors: 3 #H bond donors: 0
#Freely Rotating Bonds: 3 Polar Surface Area: 77.81 Å2
Index of Refraction: 1.729 Molar Refractivity: 118.52 cm3
Molar Volume: 297 cm3 Polarizability: 46.98 10-24cm3
Surface Tension: 65.9 dyne/cm Density: 1.49 g/cm3
Flash Point: 337.3 °C Enthalpy of Vaporization: 93.73 kJ/mol
Boiling Point: 634.1 °C at 760 mmHg Vapour Pressure: 5.51E-16 mmHg at 25°C
            
 Log Octanol-Water Partition Coef (SRC):
    Log Kow (KOWWIN v1.67 estimate) =  6.45

 Boiling Pt, Melting Pt, Vapor Pressure Estimations (MPBPWIN v1.42):
    Boiling Pt (deg C):  594.24  (Adapted Stein & Brown method)
    Melting Pt (deg C):  256.62  (Mean or Weighted MP)
    VP(mm Hg,25 deg C):  3.09E-013  (Modified Grain method)
    Subcooled liquid VP: 1.04E-010 mm Hg (25 deg C, Mod-Grain method)

 Water Solubility Estimate from Log Kow (WSKOW v1.41):
    Water Solubility at 25 deg C (mg/L):  0.002793
       log Kow used: 6.45 (estimated)
       no-melting pt equation used

 Water Sol Estimate from Fragments:
    Wat Sol (v1.01 est) =  0.018215 mg/L

 ECOSAR Class Program (ECOSAR v0.99h):
    Class(es) found:
       Allylic/Vinyl Nitriles

 Henrys Law Constant (25 deg C) [HENRYWIN v3.10]:
   Bond Method :   4.94E-014  atm-m3/mole
   Group Method:   Incomplete
 Henrys LC [VP/WSol estimate using EPI values]:  6.445E-011 atm-m3/mole

 Log Octanol-Air Partition Coefficient (25 deg C) [KOAWIN v1.10]:
  Log Kow used:  6.45  (KowWin est)
  Log Kaw used:  -11.695  (HenryWin est)
      Log Koa (KOAWIN v1.10 estimate):  18.145
      Log Koa (experimental database):  None

 Probability of Rapid Biodegradation (BIOWIN v4.10):
   Biowin1 (Linear Model)         :   0.2965
   Biowin2 (Non-Linear Model)     :   0.0092
 Expert Survey Biodegradation Results:
   Biowin3 (Ultimate Survey Model):   1.5186  (recalcitrant)
   Biowin4 (Primary Survey Model) :   2.6477  (weeks-months)
 MITI Biodegradation Probability:
   Biowin5 (MITI Linear Model)    :  -0.4347
   Biowin6 (MITI Non-Linear Model):   0.0001
 Anaerobic Biodegradation Probability:
   Biowin7 (Anaerobic Linear Model): -1.3031
 Ready Biodegradability Prediction:   NO

Hydrocarbon Biodegradation (BioHCwin v1.01):
    Structure incompatible with current estimation method!

 Sorption to aerosols (25 Dec C)[AEROWIN v1.00]:
  Vapor pressure (liquid/subcooled):  1.39E-008 Pa (1.04E-010 mm Hg)
  Log Koa (Koawin est  ): 18.145
   Kp (particle/gas partition coef. (m3/ug)):
       Mackay model           :  216 
       Octanol/air (Koa) model:  3.43E+005 
   Fraction sorbed to airborne particulates (phi):
       Junge-Pankow model     :  1 
       Mackay model           :  1 
       Octanol/air (Koa) model:  1 

 Atmospheric Oxidation (25 deg C) [AopWin v1.92]:
   Hydroxyl Radicals Reaction:
      OVERALL OH Rate Constant =  20.7421 E-12 cm3/molecule-sec
      Half-Life =     0.516 Days (12-hr day; 1.5E6 OH/cm3)
      Half-Life =     6.188 Hrs
   Ozone Reaction:
      OVERALL Ozone Rate Constant =     1.260000 E-17 cm3/molecule-sec
      Half-Life =     0.910 Days (at 7E11 mol/cm3)
      Half-Life =     21.829 Hrs
   Fraction sorbed to airborne particulates (phi): 1 (Junge,Mackay)
    Note: the sorbed fraction may be resistant to atmospheric oxidation

 Soil Adsorption Coefficient (PCKOCWIN v1.66):
      Koc    :  1.27E+007
      Log Koc:  7.104 

 Aqueous Base/Acid-Catalyzed Hydrolysis (25 deg C) [HYDROWIN v1.67]:
    Rate constants can NOT be estimated for this structure!

 Bioaccumulation Estimates from Log Kow (BCFWIN v2.17):
   Log BCF from regression-based method = 4.266 (BCF = 1.846e+004)
       log Kow used: 6.45 (estimated)

 Volatilization from Water:
    Henry LC:  4.94E-014 atm-m3/mole  (estimated by Bond SAR Method)
    Half-Life from Model River: 2.494E+010  hours   (1.039E+009 days)
    Half-Life from Model Lake : 2.721E+011  hours   (1.134E+010 days)

 Removal In Wastewater Treatment:
    Total removal:              93.36  percent
    Total biodegradation:        0.78  percent
    Total sludge adsorption:    92.59  percent
    Total to Air:                0.00  percent
      (using 10000 hr Bio P,A,S)

 Level III Fugacity Model:
           Mass Amount    Half-Life    Emissions
            (percent)        (hr)       (kg/hr)
   Air       0.000692        7.9          1000       
   Water     0.837           4.32e+003    1000       
   Soil      55.6            8.64e+003    1000       
   Sediment  43.6            3.89e+004    0          
     Persistence Time: 1.4e+004 hr