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Search term: WGRBWDOYKYLLSA-UHFFFAOYAA
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Inherent Properties, Identifiers and References
ChemSpider ID: 2843798
Empirical Formula: C27H34N4O3S
Molecular Weight: 494.6489
Nominal Mass: 494 Da
Average Mass: 494.6489 Da
Monoisotopic Mass: 494.235161 Da
Systematic Name: ethyl 1-[[4-(2-isopropylphenyl)-3-(4-methoxyphenyl)-5-thioxo-1,2,​4-triazol-1-yl]methyl]piperidine-3-carboxylate
SMILES: S=C3N(\N=C(\c1ccc(OC)cc1)N3c2ccccc2C(C)C)CN4CC(C(=O)OCC)CCC4
InChI: InChI=1/C27H34N4O3S/c1-5-34-26(32)21-9-8-16-29(17-21)18-30-27(35)​31(24-11-7-6-10-23(24)19(2)3)25(28-30)20-12-14-22(33-4)15-13-20/h​6-7,10-15,19,21H,5,8-9,16-18H2,1-4H3
InChIKey: WGRBWDOYKYLLSA-UHFFFAOYAA
Std. InChI: InChI=1S/C27H34N4O3S/c1-5-34-26(32)21-9-8-16-29(17-21)18-30-27(35​)31(24-11-7-6-10-23(24)19(2)3)25(28-30)20-12-14-22(33-4)15-13-20/​h6-7,10-15,19,21H,5,8-9,16-18H2,1-4H3
Std. InChIKey: WGRBWDOYKYLLSA-UHFFFAOYSA-N
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ACD/LogP: 4.69 # of Rule of 5 Violations: 0
ACD/LogD (pH 5.5): 4.67 ACD/LogD (pH 7.4): 4.69
ACD/BCF (pH 5.5): 2056.8 ACD/BCF (pH 7.4): 2156.04
ACD/KOC (pH 5.5): 8077.7 ACD/KOC (pH 7.4): 8467.42
#H bond acceptors: 7 #H bond donors: 0
#Freely Rotating Bonds: 9 Polar Surface Area: 89.7 Å2
Index of Refraction: 1.617 Molar Refractivity: 141.92 cm3
Molar Volume: 405.2 cm3 Polarizability: 56.26 10-24cm3
Surface Tension: 43.7 dyne/cm Density: 1.22 g/cm3
Flash Point: 300.3 °C Enthalpy of Vaporization: 85.87 kJ/mol
Boiling Point: 572.9 °C at 760 mmHg Vapour Pressure: 3.91E-13 mmHg at 25°C
            
 Log Octanol-Water Partition Coef (SRC):
    Log Kow (KOWWIN v1.67 estimate) =  8.13

 Boiling Pt, Melting Pt, Vapor Pressure Estimations (MPBPWIN v1.42):
    Boiling Pt (deg C):  622.03  (Adapted Stein & Brown method)
    Melting Pt (deg C):  269.60  (Mean or Weighted MP)
    VP(mm Hg,25 deg C):  4.01E-014  (Modified Grain method)
    Subcooled liquid VP: 1.95E-011 mm Hg (25 deg C, Mod-Grain method)

 Water Solubility Estimate from Log Kow (WSKOW v1.41):
    Water Solubility at 25 deg C (mg/L):  8.854e-005
       log Kow used: 8.13 (estimated)
       no-melting pt equation used

 Water Sol Estimate from Fragments:
    Wat Sol (v1.01 est) =  0.0011078 mg/L

 ECOSAR Class Program (ECOSAR v0.99h):
    Class(es) found:
       Aliphatic Amines
       Esters
       Hydrazines

 Henrys Law Constant (25 deg C) [HENRYWIN v3.10]:
   Bond Method :   1.65E-011  atm-m3/mole
   Group Method:   Incomplete
 Henrys LC [VP/WSol estimate using EPI values]:  2.948E-010 atm-m3/mole

 Log Octanol-Air Partition Coefficient (25 deg C) [KOAWIN v1.10]:
  Log Kow used:  8.13  (KowWin est)
  Log Kaw used:  -9.171  (HenryWin est)
      Log Koa (KOAWIN v1.10 estimate):  17.301
      Log Koa (experimental database):  None

 Probability of Rapid Biodegradation (BIOWIN v4.10):
   Biowin1 (Linear Model)         :   0.8777
   Biowin2 (Non-Linear Model)     :   0.9664
 Expert Survey Biodegradation Results:
   Biowin3 (Ultimate Survey Model):   1.8043  (months      )
   Biowin4 (Primary Survey Model) :   3.2890  (days-weeks  )
 MITI Biodegradation Probability:
   Biowin5 (MITI Linear Model)    :   0.0691
   Biowin6 (MITI Non-Linear Model):   0.0069
 Anaerobic Biodegradation Probability:
   Biowin7 (Anaerobic Linear Model): -2.0085
 Ready Biodegradability Prediction:   NO

Hydrocarbon Biodegradation (BioHCwin v1.01):
    Structure incompatible with current estimation method!

 Sorption to aerosols (25 Dec C)[AEROWIN v1.00]:
  Vapor pressure (liquid/subcooled):  2.6E-009 Pa (1.95E-011 mm Hg)
  Log Koa (Koawin est  ): 17.301
   Kp (particle/gas partition coef. (m3/ug)):
       Mackay model           :  1.15E+003 
       Octanol/air (Koa) model:  4.91E+004 
   Fraction sorbed to airborne particulates (phi):
       Junge-Pankow model     :  1 
       Mackay model           :  1 
       Octanol/air (Koa) model:  1 

 Atmospheric Oxidation (25 deg C) [AopWin v1.92]:
   Hydroxyl Radicals Reaction:
      OVERALL OH Rate Constant = 376.6515 E-12 cm3/molecule-sec
      Half-Life =     0.028 Days (12-hr day; 1.5E6 OH/cm3)
      Half-Life =    20.446 Min
   Ozone Reaction:
      No Ozone Reaction Estimation
   Fraction sorbed to airborne particulates (phi): 1 (Junge,Mackay)
    Note: the sorbed fraction may be resistant to atmospheric oxidation

 Soil Adsorption Coefficient (PCKOCWIN v1.66):
      Koc    :  1.482E+005
      Log Koc:  5.171 

 Aqueous Base/Acid-Catalyzed Hydrolysis (25 deg C) [HYDROWIN v1.67]:
  Total Kb for pH > 8 at 25 deg C :  1.639E-003  L/mol-sec
  Kb Half-Life at pH 8:      13.400  years  
  Kb Half-Life at pH 7:     133.996  years  

 Bioaccumulation Estimates from Log Kow (BCFWIN v2.17):
   Log BCF from regression-based method = 3.263 (BCF = 1834)
       log Kow used: 8.13 (estimated)

 Volatilization from Water:
    Henry LC:  1.65E-011 atm-m3/mole  (estimated by Bond SAR Method)
    Half-Life from Model River: 7.892E+007  hours   (3.288E+006 days)
    Half-Life from Model Lake : 8.609E+008  hours   (3.587E+007 days)

 Removal In Wastewater Treatment:
    Total removal:              94.02  percent
    Total biodegradation:        0.78  percent
    Total sludge adsorption:    93.24  percent
    Total to Air:                0.00  percent
      (using 10000 hr Bio P,A,S)

 Level III Fugacity Model:
           Mass Amount    Half-Life    Emissions
            (percent)        (hr)       (kg/hr)
   Air       0.00668         0.682        1000       
   Water     1.4             1.44e+003    1000       
   Soil      30.2            2.88e+003    1000       
   Sediment  68.4            1.3e+004     0          
     Persistence Time: 4.71e+003 hr