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Search term: 1005775-56-3 (Found by approved synonym)
ChemSpider 2D Image | ASK1 Inhibitor 10 | C21H23Cl2N5O

ASK1 Inhibitor 10

  • Molecular FormulaC21H23Cl2N5O
  • Average mass432.346 Da
  • Monoisotopic mass431.127960 Da
  • ChemSpider ID29422707

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1005775-56-3 [RN]
4-tert-butyl-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide dihydrochloride
4-tert-butyl-N-[6-(imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]benzamide dihydrochloride
ASK1 Inhibitor 10
Benzamide, 4-(1,1-dimethylethyl)-N-[6-(1H-imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]-, hydrochloride (1:2) [ACD/Index Name]
N-[6-(1H-Imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]-4-(2-methyl-2-propanyl)benzamiddihydrochlorid [German] [ACD/IUPAC Name]
N-[6-(1H-Imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]-4-(2-methyl-2-propanyl)benzamide dihydrochloride [ACD/IUPAC Name]
N-[6-(1H-Imidazol-1-yl)imidazo[1,2-a]pyridin-2-yl]-4-(2-méthyl-2-propanyl)benzamide, dichlorhydrate [French] [ACD/IUPAC Name]
[1005775-56-3] [RN]
4-?(1,?1-?dimethylethyl)?-?N-?[6-?(1H-?imidazol-?1-?yl)?imidazo[1,?2-?a]?pyridin-?2-?yl]?-?Benzamide, hydrochloride (1:2)
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Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 4693 [DBID]
PubChem Substance ID 329825761 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      ASK1 Tocris Bioscience 4825
      Enzymes Tocris Bioscience 4825
      Kinases Tocris Bioscience 4825
      Potent and selective ASK1 inhibitor; orally bioavailable Tocris Bioscience 4825
      Potent ASK1 inhibitor (IC50 = 14 nM); displays selectivity for ASK1 over other kinases including ASK2 (IC50 = 0.51 ?M), MEKK1, TAK1, IKK?, ERK1, JNK1, p38?, GSK-3?, PKC? and B-raf (IC50 values are > 1 0 ?M). Blocks downstream JNK1/p38 phosphorylation in cells. Orally bioavailable. Tocris Bioscience 4825
      Potent ASK1 inhibitor (IC50 = 14 nM); displays selectivity for ASK1 over other kinases including ASK2 (IC50 = 0.51 ?M), MEKK1, TAK1, IKK?, ERK1, JNK1, p38?, GSK-3?, PKC? and B-raf (IC50 values are > 10 ?M). Blocks downstream JNK1/p38 phosphorylation in cells. Orally bioavailable. Tocris Bioscience 4825
      Potent ASK1 inhibitor (IC50 = 14 nM); displays selectivity for ASK1 over other kinases including ASK2 (IC50 = 0.51 muM), MEKK1, TAK1, IKKbeta, ERK1, JNK1, p38alpha, GSK-3beta, PKCtheta and B-raf (IC50 values are > 10 muM). Blocks downstream JNK1/p38 phosphorylation in cells. Orally bioavailable. Tocris Bioscience 4825

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

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