Found 1 result

Search term: 1186195-62-9 (Found by approved synonym)
ChemSpider 2D Image | IKK-16 (hydrochloride) | C28H30ClN5OS

IKK-16 (hydrochloride)

  • Molecular FormulaC28H30ClN5OS
  • Average mass520.089 Da
  • Monoisotopic mass519.185974 Da
  • ChemSpider ID21475131

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(4-{[4-(1-Benzothiophen-2-yl)-2-pyrimidinyl]amino}phenyl)[4-(1-pyrrolidinyl)-1-piperidinyl]methanone hydrochloride (1:1) [ACD/IUPAC Name]
(4-{[4-(1-Benzothiophén-2-yl)-2-pyrimidinyl]amino}phényl)[4-(1-pyrrolidinyl)-1-pipéridinyl]méthanone, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
(4-{[4-(1-Benzothiophen-2-yl)-2-pyrimidinyl]amino}phenyl)[4-(1-pyrrolidinyl)-1-piperidinyl]methanonhydrochlorid (1:1) [German] [ACD/IUPAC Name]
(4-{[4-(1-Benzothiophen-2-yl)pyrimidin-2-yl]amino}phenyl)[4-(pyrrolidin-1-yl)piperidin-1-yl]methanone hydrochloride (1:1)
1186195-62-9 [RN]
IKK-16 (hydrochloride)
Methanone, [4-[(4-benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-, hydrochloride (1:1) [ACD/Index Name]
[1186195-62-9] [RN]
[4-[(4-benzo[b]thien-2-yl-2-pyrimidinyl)amino]phenyl][4-(1-pyrrolidinyl)-1-piperidinyl]-methanone, monohydrochloride
1186195-62-9 (HCl)
More...
  • Experimental Physico-chemical Properties

    • Experimental Solubility:

      Soluble to 50 mM in water and to 100 mM in DMSO Tocris Bioscience 2539
      Soluble to 50 mM in water and to 50 mM in DMSO Tocris Bioscience 2539
  • Miscellaneous

    • Bio Activity:

      Enzymes Tocris Bioscience 2539
      IkB Kinase Tocris Bioscience 2539
      Kinases Tocris Bioscience 2539
      Selective inhibitor of I?B kinase (IKK) (IC50 values are 40, 70 and 200 nM for IKK?, IKK complex and IKK? respectively). Inhibits TNF-?-stimulated I?B degradation and expression of adhesion molecules E-selectin, ICAM and VCAM (IC50 values are 1.0, 0.5, 0.3 and 0.3 ?M respectively). Inhibits LPS-induced TNF-? release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis. Tocris Bioscience 2539
      Selective inhibitor of I?B kinase (IKK) (IC50 values are 40, 70 and 200 nM for IKK?, IKK complex and IKK? respectively). Inhibits TNF-?-stimulated I?B degradation and expression of adhesion molecules E-selectin, ICAM and VCAM (IC50 values are 1.0, 0.5, 0.3 and 0.3 ?M respectively). Inhibits LPS-induced TNF-? release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis. Tocris Bioscience 2539
      Selective inhibitor of IkappaB kinase (IKK) (IC50 values are 40, 70 and 200 nM for IKKbeta, IKK complex and IKKalpha respectively). Inhibits TNF-alpha-stimulated IkappaB degradation and expression of adhesion molecules E-selectin, ICAM and VCAM (IC50 values are 1.0, 0.5, 0.3 and 0.3 muM respectively). Inhibits LPS-induced TNF-alpha release in vivo and neutrophil extravasion in thioglycollate-induced peritonitis. Tocris Bioscience 2539
      Selective inhibitor of IKK Tocris Bioscience 2539

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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