Found 1 result

Search term: 1225451-84-2 (Found by approved synonym)
ChemSpider 2D Image | SKLB1002 | C13H12N4O2S2

SKLB1002

  • Molecular FormulaC13H12N4O2S2
  • Average mass320.390 Da
  • Monoisotopic mass320.040161 Da
  • ChemSpider ID28663597

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1225451-84-2 [RN]
2-((6,7-Dimethoxyquinazolin-4-yl)thio)-5-methyl-1,3,4-thiadiazole
6,7-Dimethoxy-4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]chinazolin [German] [ACD/IUPAC Name]
6,7-Dimethoxy-4-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanyl]quinazoline [ACD/IUPAC Name]
6,7-Diméthoxy-4-[(5-méthyl-1,3,4-thiadiazol-2-yl)sulfanyl]quinazoline [French] [ACD/IUPAC Name]
6,7-Dimethoxy-4-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]-quinazoline
MFCD27938707
Quinazoline, 6,7-dimethoxy-4-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]- [ACD/Index Name]
SKLB 1002
SKLB1002
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      VEGFR inhibitor TargetMol T2421

    • Bio Activity:

      Protein Tyrosine Kinase/RTK MedChem Express HY-13944
      Protein Tyrosine Kinase/RTK; MedChem Express HY-13944
      SKLB1002 is a novel and potent VEGFR-2 inhibitor with an IC50 value of 32 nM. MedChem Express
      SKLB1002 is a novel and potent VEGFR-2 inhibitor with an IC50 value of 32 nM.; IC50 Value: 32 nM [1]; Target: VEGFR-2; in vitro: SKLB1002 showed potent inhibition of VEGFR2 kinase activity (IC50 = 32 nmol/L), which was similar with the positive drugs vandetanib (IC50 = 40 nmol/L) and sunitinib (IC50 = 9 nmol/L). MedChem Express HY-13944
      Tyrosine Kinase/Adaptors TargetMol T2421
      VEGFR MedChem Express HY-13944
      VEGFR2 TargetMol T2421

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.5±0.1 g/cm3
Boiling Point: 522.4±60.0 °C at 760 mmHg
Vapour Pressure: 0.0±1.3 mmHg at 25°C
Enthalpy of Vaporization: 76.6±3.0 kJ/mol
Flash Point: 269.7±32.9 °C
Index of Refraction: 1.687
Molar Refractivity: 83.7±0.4 cm3
#H bond acceptors: 6
#H bond donors: 0
#Freely Rotating Bonds: 4
#Rule of 5 Violations: 0
ACD/LogP: 2.40
ACD/LogD (pH 5.5): 2.06
ACD/BCF (pH 5.5): 21.60
ACD/KOC (pH 5.5): 313.90
ACD/LogD (pH 7.4): 2.06
ACD/BCF (pH 7.4): 21.60
ACD/KOC (pH 7.4): 313.90
Polar Surface Area: 124 Å2
Polarizability: 33.2±0.5 10-24cm3
Surface Tension: 80.0±5.0 dyne/cm
Molar Volume: 219.8±5.0 cm3

Click to predict properties on the Chemicalize site


Advertisement