Found 1 result

Search term: 1337532-29-2 (Found by approved synonym)
ChemSpider 2D Image | GSK2656157 | C23H21FN6O

GSK2656157

  • Molecular FormulaC23H21FN6O
  • Average mass416.451 Da
  • Monoisotopic mass416.176086 Da
  • ChemSpider ID30798106

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1-(5-{4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-4-fluoro-2,3-dihydro-1H-indol-1-yl)-2-(6-methylpyridin-2-yl)ethan-1-one
1-(5-{4-amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl}-4-fluoro-2,3-dihydroindol-1-yl)-2-(6-methylpyridin-2-yl)ethanone
1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluor-2,3-dihydro-1H-indol-1-yl]-2-(6-methyl-2-pyridinyl)ethanon [German] [ACD/IUPAC Name]
1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydro-1H-indol-1-yl]-2-(6-methyl-2-pyridinyl)ethanone [ACD/IUPAC Name]
1-[5-(4-Amino-7-méthyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydro-1H-indol-1-yl]-2-(6-méthyl-2-pyridinyl)éthanone [French] [ACD/IUPAC Name]
1337532-29-2 [RN]
Ethanone, 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydro-1H-indol-1-yl]-2-(6-methyl-2-pyridinyl)- [ACD/Index Name]
GSK2656157
[1337532-29-2] [RN]
1-(5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoroindolin-1-yl)-2-(6-methylpyridin-2-yl)ethan-1-one
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Target Organs:

      PERK inhibitor TargetMol T2654

    • Chemical Class:

      A pyrrolopyrimidine that is 7-methyl-7<element>H</element>-pyrrolo[2,3-<ital>d</ital>]pyrimidin-4-amine which has been substituted at position 5 by a 4-fluoro-2,3-dihydro-1<element>H</element>-indol-5 -yl group, the nitrogen of which has been acylated by a (6-methylpyridin-2-yl)acetyl group. An orally bioavailable PERK inhibitor. ChEBI CHEBI:139047
      A pyrrolopyrimidine that is 7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine which has been substituted at position 5 by a 4-fluoro-2,3-dihydro-1H-indol-5-yl group, the nitrogen of which has been acylated by a (6-methylpyridin-2-yl)acetyl group. An orally bioavailable PERK inhibitor. ChEBI CHEBI:139047

    • Bio Activity:

      Apoptosis TargetMol T2654
      Cell Cycle/DNA Damage MedChem Express HY-13820
      Cell Cycle/DNA Damage; MedChem Express HY-13820
      GSK2656157 is an ATP-competitive inhibitor of PERK enzyme activity with an IC(50) of 0.9 nM; is highly selective for PERK with IC50 values >100 nM against a panel of 300 kinases.; IC50 value: 0.9 nM [1]; Target: PERK; in vitro: GSK2656157 inhibits PERK activity in cells with an IC(50) in the range of 10-30 nmol/L as shown by inhibition of stress-induced PERK autophosphorylation, eIF2? substrate phosphorylation, together with corresponding decreases in ATF4 and CAAT/enhancer binding protein homologous protein (CHOP) in multiple cell lines [1]. MedChem Express HY-13820
      PERK MedChem Express HY-13820
      PERK TargetMol T2654

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.4±0.1 g/cm3
Boiling Point: 744.6±60.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.5 mmHg at 25°C
Enthalpy of Vaporization: 108.6±3.0 kJ/mol
Flash Point: 404.1±32.9 °C
Index of Refraction: 1.722
Molar Refractivity: 115.1±0.5 cm3
#H bond acceptors: 7
#H bond donors: 2
#Freely Rotating Bonds: 3
#Rule of 5 Violations: 0
ACD/LogP: 3.43
ACD/LogD (pH 5.5): 2.32
ACD/BCF (pH 5.5): 26.08
ACD/KOC (pH 5.5): 262.76
ACD/LogD (pH 7.4): 2.79
ACD/BCF (pH 7.4): 76.74
ACD/KOC (pH 7.4): 773.12
Polar Surface Area: 90 Å2
Polarizability: 45.6±0.5 10-24cm3
Surface Tension: 55.5±7.0 dyne/cm
Molar Volume: 290.9±7.0 cm3

Click to predict properties on the Chemicalize site


Advertisement