Found 1 result

Search term: 192927-92-7 (Found by approved synonym)
ChemSpider 2D Image | LY-310,762 hydrochloride | C24H28ClFN2O2

LY-310,762 hydrochloride

  • Molecular FormulaC24H28ClFN2O2
  • Average mass430.943 Da
  • Monoisotopic mass430.182343 Da
  • ChemSpider ID10131824

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

1-{2-[4-(4-Fluorbenzoyl)-1-piperidinyl]ethyl}-3,3-dimethyl-1,3-dihydro-2H-indol-2-onhydrochlorid (1:1) [German] [ACD/IUPAC Name]
1-{2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl}-3,3-dimethyl-1,3-dihydro-2H-indol-2-one hydrochloride (1:1) [ACD/IUPAC Name]
1-{2-[4-(4-Fluorobenzoyl)-1-pipéridinyl]éthyl}-3,3-diméthyl-1,3-dihydro-2H-indol-2-one, chlorhydrate (1:1) [French] [ACD/IUPAC Name]
1-{2-[4-(4-Fluorobenzoyl)piperidin-1-yl]ethyl}-3,3-dimethyl-1,3-dihydro-2H-indol-2-one hydrochloride (1:1)
1-{2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl}-3,3-dimethyl-2,3-dihydro-1H-indol-2-one hydrochloride
1-{2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl}-3,3-dimethylindol-2-one hydrochloride
192927-92-7 [RN]
2H-Indol-2-one, 1-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-1,3-dihydro-3,3-dimethyl-, hydrochloride (1:1) [ACD/Index Name]
3,3-Dimethyl-1-{2-[4-(4-fluorobenzoyl)-1-piperidinyl]-1-ethyl}-1,3-dihydro-2H-indol-2-one hydrochloride
LY-310,762 hydrochloride
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CCRIS 4693 [DBID]
EU-0100658 [DBID]
L2536_SIGMA [DBID]
  • References
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Safety:

      Sold under license from Eli Lilly and company Tocris Bioscience 3078

    • Target Organs:

      5-HT Receptor antagonist TargetMol T2688

    • Chemical Class:

      A hydrochloride resulting from the formal reation of equimolar amount of LY-310762 with hydrogen chloride. A potent and selective antagonist for the 5-hydroxytryptamine 1D (5-HT1D) receptor. ChEBI CHEBI:140935
      A hydrochloride resulting from the formal reation of equimolar amount of LY-310762 with hydrogen chloride. A potent and selective antagonist for the 5-hydroxytryptamine 1D (5-HT1D; ) receptor. ChEBI https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:140935
      Serotonin EU-OpenScreen [L 2536]

    • Bio Activity:

      5-HT Receptor MedChem Express HY-13527
      5-HT Receptors Tocris Bioscience 3078
      5-HT<sub>1D</sub>-preferring receptor antagonist Hello Bio HB1751
      5-HT<sub>1D</sub>-preferring receptor antagonist (EC<sub>50</sub> = 31 nM). Hello Bio HB1751
      5-HT1 Receptors Tocris Bioscience 3078
      5-HT1D receptor TargetMol T2688
      5-HT1D-preferring antagonist Tocris Bioscience 3078
      5-HT1D-preferring receptor antagonist (EC50 = 31 nM). Displays no activity on 5-HT transport. Tocris Bioscience 3078
      7-TM Receptors Tocris Bioscience 3078
      Biochemicals & small molecules/Antagonists & inhibitors Hello Bio HB1751
      GPCR/G protein MedChem Express HY-13527
      GPCR/G protein; Neuronal Signaling; MedChem Express HY-13527
      LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM, having a weaker affinity for 5-HT1B receptor. MedChem Express
      LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM, having a weaker affinity for 5-HT1B receptor.; IC50 value: 249 nM (Ki) [1]; Target: 5-HT1D ; in vitro: LY310762 has a higher affinity for the guinea pig 5-HT1D receptor than for the 5-HT1B receptor. MedChem Express HY-13527
      LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM, having a weaker affinity for 5-HT1B receptor.;IC50 value: 249 nM (Ki) [1];Target: 5-HT1D ;In vitro: LY310762 has a higher affinity for the guinea pig 5-HT1D receptor than for the 5-HT1B receptor. LY310762 potentiates the potassium-induced [3H]5-HT outflow from guinea pig cortical slices with an EC50 of 30 nM. The maximum potentiation of the potassium-induced outflow which is obtained with LY310762 is about 40% [1]. LY310762 blocks the decreased EPSC amplitude induced by Sumatriptan [2]. ;In vivo: Systemic administration of LY310762 (10 mg/kg i.p.) produces a further significant enhancement in the 5-HT response to fluoxetine (20 mg/kg i.p.) when compared to animals receiving a control vehicle injection. In fluoxetine treated animals, levels of 5-HT increases from 312?43% to a maximum of 683% after LY310762. In control animals, levels of 5-HT remains unchanged (250%). LY310762 administered alone also significantly increases MedChem Express HY-13527
      Neuroscience TargetMol T2688
      Receptors & Transporters/G protein coupled receptors/5-HT/5-HT<sub>1</sub>/5-HT<sub>1D</sub> Hello Bio HB1751

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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