Found 1 result

Search term: 6054-98-4 (Found by approved synonym)
ChemSpider 2D Image | Olsalazine sodium | C14H8N2Na2O6

Olsalazine sodium

  • Molecular FormulaC14H8N2Na2O6
  • Average mass346.203 Da
  • Monoisotopic mass346.017761 Da
  • ChemSpider ID10482009

  • Charge - Charge

    Double-bond stereo - Double-bond stereo

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

3,3'-(E)-diazène-1,2-diylbis(6-hydroxybenzoate) de disodium
3,3'-[(E)-1,2-Diazènediyl]bis(6-hydroxybenzoate) de disodium [French] [ACD/IUPAC Name]
6054-98-4 [RN]
Azodisal sodium
Benzoic acid, 3,3'-[(E)-1,2-diazenediyl]bis[6-hydroxy-, sodium salt (1:2) [ACD/Index Name]
Benzoic acid, 3,3'-azobis[6-hydroxy-, disodium salt
Dinatrium-3,3'-(E)-diazen-1,2-diylbis(6-hydroxybenzolcarboxylat)
Dinatrium-3,3'-[(E)-1,2-diazendiyl]bis(6-hydroxybenzoat) [German] [ACD/IUPAC Name]
Dipentum [Trade name]
Disodium 3,3'-(E)-diazene-1,2-diylbis(6-hydroxybenzoate)
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

C.I. 14130 [DBID]
D00727 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      An organic sodium salt that is the disodium salt of 3,3'-azobis(6-hydroxybenzoic acid) (olsalazine). Effective in the treatment of inflammatory bowel disease and ulcerative colitis. Mechanism of actio n unknown, but appears to be topical ChEBI CHEBI:63614

    • Bio Activity:

      Antibacterial MedChem Express HY-B0174
      Anti-infection MedChem Express HY-B0174
      Anti-infection; MedChem Express HY-B0174
      Olsalazine is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease and Ulcerative Colitis. MedChem Express
      Olsalazine is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease and Ulcerative Colitis.; Target: Antibacterial; Olsalazine is a derivative of salicylic acid. MedChem Express HY-B0174
      Olsalazine is an anti-inflammatory drug used in the treatment of Inflammatory Bowel Disease and Ulcerative Colitis.;Target: AntibacterialOlsalazine is a derivative of salicylic acid. Inactive by itself (it is a prodrug), it is converted by the bacteria in the colon to mesalamine. Olsalazine is potent inhibitors of human intestinal macrophages chemotaxis to LTB4 with IC50 of 0.39 mM. Olsalazine (0.4 mM) inhibits the superoxide radical production generated by phorbol myristate acetate (PMA)-activated neutrophils or by xanthine-xanthine oxidase reaction by reduction of 31% and 73%, respectively. Olsalazine inhibits tumor growth in a rodent model of colorectal cancer. In 1,2-dimethylhydrazine-treated rats, Olsalazine (25 mg/kg/day) decreases number and volume of tumors by 58.17% and 62.67%, respectively. Administration of Olsalazine induces a 1.7-fold times increase in the number of apoptotic cells, companied with a reduction of 42.4% in cell proliferation rate. MedChem Express HY-B0174

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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