Found 1 result

Search term: 66104-23-2 (Found by approved synonym)
ChemSpider 2D Image | Pergolide mesylate | C20H30N2O3S2

Pergolide mesylate

  • Molecular FormulaC20H30N2O3S2
  • Average mass410.594 Da
  • Monoisotopic mass410.169769 Da
  • ChemSpider ID43504

  • defined stereocentres - 3 of 3 defined stereocentres

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

(6aR,9R,10aR)-9-[(methylsulfanyl)methyl]-7-propyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline methanesulfonate
(8β)-8-[(methylsulfanyl)methyl]-6-propylergoline methanesulfonate
(8β)-8-[(Methylsulfanyl)methyl]-6-propylergoline methanesulfonate (1:1) [ACD/IUPAC Name]
55B9HQY616
66104-23-2 [RN]
8-b-((Methylthio)methyl)-6-propylergoline Methanesulfonate
8b-((Methylthio)methyl)-6-propylergoline Monomethanesulfonate
8β-[(Methylthio)methyl]-6-propylergoline methanesulfonate salt
acide méthanesulfonique - (6aR,9R,10aR)-9-[(méthylsulfanyl)méthyl]-7-propyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoléine (1:1) [French]
Acide méthanesulfonique - (8β)-8-[(méthylsulfanyl)méthyl]-6-propylergoline (1:1) [French] [ACD/IUPAC Name]
More...

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

CHEBI:8021 [DBID]
LY 127809 [DBID]
D00502 [DBID]
EU-0100984 [DBID]
LY-127809 [DBID]
MLS000069837 [DBID]
NSC319773 [DBID]
P8828_SIGMA [DBID]
Prestwick_652 [DBID]
SMR000058504 [DBID]
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Chemical Class:

      A methanesulfonate salt obtained from pergolide by mixing eqimolar amount of pergolide and methanesulfonic acid. A dopamine D<smallsub>2</smallsub> receptor agonist which also has D<smallsub>1</smalls ub> and D<smallsub>2</smallsub> agonist properties, it is used in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk o f cardiac valve dysfunction. ChEBI CHEBI:8021
      A methanesulfonate salt obtained from pergolide by mixing eqimolar amount of pergolide and methanesulfonic acid. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it is used in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction. ChEBI https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:8021, CHEBI:8021

    • Bio Activity:

      Dopamine Receptor MedChem Express HY-13720A
      GPCR/G protein MedChem Express HY-13720A
      GPCR/G protein; Neuronal Signaling; MedChem Express HY-13720A
      Pergolide Mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist. MedChem Express
      Pergolide Mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist.; Target: Dopamine Receptor; Pergolide mesylate (trade name Permax) is an ergoline-based dopamine receptor agonist used in some countries for the treatment of Parkinson's disease. MedChem Express HY-13720A
      Pergolide Mesylate is an antiparkinsonian agent which functions as a dopaminergic agonist.;Target: Dopamine ReceptorPergolide mesylate (trade name Permax) is an ergoline-based dopamine receptor agonist used in some countries for the treatment of Parkinson's disease. Pergolide mesylate functions as an agonist at the dopamine D2, D1 and serotonin 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, and 5-HT2C receptors. It may possess agonist activity at other dopamine receptor subtypes as well, similar to cabergoline [1, 2]. Pergolide mesylate decreases plasma prolactin concentrations [3]. The weak agonist activity of pergolide at D1 receptors somewhat alters its clinical and side effect profile in the treatment of Parkinson's disease. The drug is in decreasing use, as it is reported to be associated with a form of heart disease called cardiac fibrosis. The use of pergolide or cabergoline is associated with a significantly increased risk of newly diagnosed cardiac-valve regurgitation [4]. MedChem Express HY-13720A

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

No predicted properties have been calculated for this compound.

Click to predict properties on the Chemicalize site


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