Found 1 result

Search term: 801312-28-7 (Found by approved synonym)
ChemSpider 2D Image | GSK256066 | C27H26N4O5S

GSK256066

  • Molecular FormulaC27H26N4O5S
  • Average mass518.584 Da
  • Monoisotopic mass518.162415 Da
  • ChemSpider ID8003709

More details:

Validated by Experts, Validated by Users, Non-Validated, Removed by Users

2D6GK059SR
3-Quinolinecarboxamide, 6-[[3-[(dimethylamino)carbonyl]phenyl]sulfonyl]-4-[(3-methoxyphenyl)amino]-8-methyl- [ACD/Index Name]
6-[3-(dimethylcarbamoyl)benzenesulfonyl]-4-[(3-methoxyphenyl)amino]-8-methylquinoline-3-carboxamide
6-{[3-(Dimethylcarbamoyl)phenyl]sulfonyl}-4-[(3-methoxyphenyl)amino]-8-methyl-3-chinolincarboxamid [German] [ACD/IUPAC Name]
6-{[3-(Diméthylcarbamoyl)phényl]sulfonyl}-4-[(3-méthoxyphényl)amino]-8-méthyl-3-quinoléinecarboxamide [French] [ACD/IUPAC Name]
6-{[3-(Dimethylcarbamoyl)phenyl]sulfonyl}-4-[(3-methoxyphenyl)amino]-8-methyl-3-quinolinecarboxamide [ACD/IUPAC Name]
801312-28-7 [RN]
GSK256066
GSK-256066
(+)-2-hydroxy-3-indol-3-yl-propionic acid
More...
  • Experimental Physico-chemical Properties
  • Miscellaneous

    • Bio Activity:

      GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, MedChem Express http://www.medchemexpress.com/LY2811376.html
      GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380,000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.; IC50 value: 3.2 pM [1]; Target: PDE4B; in vitro: GSK256066 is a slow and tight binding inhibitor of PDE4B with apparent IC50 of 3.2 pM. MedChem Express HY-10469
      Immunology/Inflammation MedChem Express HY-10469
      Immunology/Inflammation; Metabolic Enzyme/Protease; MedChem Express HY-10469
      PDE4 MedChem Express HY-10469

Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, version: 14.00

Density: 1.3±0.1 g/cm3
Boiling Point: 791.7±60.0 °C at 760 mmHg
Vapour Pressure: 0.0±2.8 mmHg at 25°C
Enthalpy of Vaporization: 115.1±3.0 kJ/mol
Flash Point: 432.6±32.9 °C
Index of Refraction: 1.654
Molar Refractivity: 141.2±0.4 cm3
#H bond acceptors: 9
#H bond donors: 3
#Freely Rotating Bonds: 7
#Rule of 5 Violations: 1
ACD/LogP: 3.63
ACD/LogD (pH 5.5): 3.39
ACD/BCF (pH 5.5): 223.11
ACD/KOC (pH 5.5): 1665.15
ACD/LogD (pH 7.4): 3.40
ACD/BCF (pH 7.4): 225.29
ACD/KOC (pH 7.4): 1681.47
Polar Surface Area: 140 Å2
Polarizability: 56.0±0.5 10-24cm3
Surface Tension: 61.2±3.0 dyne/cm
Molar Volume: 385.4±3.0 cm3

Click to predict properties on the Chemicalize site


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