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18 10 2007

A Challenge to the Synthetic Organic Chemist Community - Meet Quindolinocryptotackieine

Posted by: Antony Williams in ChemSpider Chemistry

Copyright©2007 Antony Williams

Attention synthetic organic chemists. Most scientists have skeletons in the closet. Problems they cannot solve and observations they cannot explain. A couple of years ago I was involved in a project to slve the structure of a compound. It had remained unresolved by manual interrogation of the NMR data for over a decade. The application of a computer-assisted structure elucidation system helped resolve the structure. It is described in detail in this publication.

Quindolinocryptotackieine: the elucidation of a novel indoloquinoline alkaloid structure through the use of computer-assisted structure elucidation and 2D NMR

Now, we THINK we have it elucidated correctly. However, we would like to confirm it. Synthesis of the molecule in question, further NMR data generation and a crystal structure would help finish this work fully. This is a call to organic chemists to participate in a hobby project. Anybody want to help? We guarantee a publication etc. The structure is shown below. Contact me at antonyDOTwilliamsATChemspiderDOTcom. Thanks!

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This entry was posted on Thursday, October 18th, 2007 at 11:37 pm and is filed under ChemSpider Chemistry. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

2 Responses to “A Challenge to the Synthetic Organic Chemist Community - Meet Quindolinocryptotackieine”

  1. Ryan's Blog on NMR Software says:
    October 19th, 2007 at 2:20 pm

    Meet Quindolinocryptotackiene

    Tony over at ChemSpider takes us on a trip down memory lane to one of the most successful stories surrounding Computer Assisted Structure Elucidation (CASE). It is also the best example of achieving symbiosis between a spectroscopist (in this case

  2. Antony Williams says:
    October 25th, 2007 at 1:25 pm

    I’m happy to announce that a group has stepped up and shown interest in synthesizing the compound and are presently researching a synthetic path. If they choose to move forward then I will introduce them via this blog and we’ll track the work in the interests of Open Notebook Science

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