Comments on: I’m Hard to Impress….I’m IMPRESSED!!! CLiDE can convert Palytoxin without error http://www.chemspider.com/blog/im-hard-to-impressim-impressed-clide-can-convert-palytoxin-without-error.html Building Community for Chemists Tue, 21 May 2013 16:16:29 +0000 hourly 1 http://wordpress.org/?v=3.5 By: David Bradley http://www.chemspider.com/blog/im-hard-to-impressim-impressed-clide-can-convert-palytoxin-without-error.html/comment-page-1#comment-3187 David Bradley Fri, 05 Oct 2007 17:18:55 +0000 http://www.chemspider.com/blog/?p=198#comment-3187 Gary’s exactly right. It takes me ten minutes to get even a simple functionalised benzene ring drawn properly. An automated way of pulling out proper fully-fledged structures from flat documents has to be one of the most important innovations for bringing the old chemical literature kicking and screaming into the second decade of the 21st century. Oh, incidentally, I reviewed an earlier version of Clide for Elemental Discoveries in April 2003 you can find it on my Sciencebase site.

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]]> By: Gary Martin http://www.chemspider.com/blog/im-hard-to-impressim-impressed-clide-can-convert-palytoxin-without-error.html/comment-page-1#comment-3155 Gary Martin Thu, 04 Oct 2007 22:31:16 +0000 http://www.chemspider.com/blog/?p=198#comment-3155 OK, so the website has nothing to do with science, but rather reflects one of my other passions. No apologies for that.

Having drawn palytoxin by hand for purposes of a review article some time ago, getting it done in seconds, vs. probably the 20 or so min it takes you to draw the molecule by hand is a Godsend! One of the problems with any big structure is that you never get right how the damned thing is laid out the first time and you spend a lot of time correcting that, dragging things around to make room for something, not to mention the time spent going in and getting all of the stereochemical orientations correct, and then putting in all the OH groups, ether oxygens, and all the rest of it. Then there’s the rather laborious problem of checking the structure to make sure that you got all the stereochemistry right!

Suffice it to say that I too am impressed!!!

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