Copyright©2008 Antony Williams
An article entitled The Search for Unusual Suspects discusses the fact that scaffold hopping expands the range of core molecular shapes for lead generation. This is of particular interest to us here at ChemSpider because it discusses LASSO. For those of you watching the blog you will know that we are in the process of implementing LASSO here on ChemSpider. One of the specific advantages of the LASSO descriptor is the ability to scaffold-hop. This is defined in the article and quoted here:
The term “scaffold hopping” was coined by former Hoffmann-La Roche researcher Gisbert Schneider. “It defines the techniques used to identify isofunctional molecules — molecules that have the same bioactivity but different architecture — in other words, different chemotypes,”
Rather than try to do justice to the article I recommend reading the article here.
Also, expect to see LASSO rollout in the the very near future here on ChemSpider.Stumble it!