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PaclitaxelCoherent anti-Stokes Raman scattering microscopy has been used to evaluate a new approach to the controlled released of the drug paclitaxel used in preventing a re-narrowing of blood vessels following insertion of a coated-stent to treat the initial condition.

Paclitaxel (aka Taxol) is added to PLGA, poly(lactic-co-glycolic acid, and used to coat blood vessel stents. This reduces the risk of restenosis and cuts target-vessel revascularization. PEG is now added as a plasticizer, but little is known about the release mechanism from these polymer blends.

Now, Kinam Park and colleagues at Purdue University have used CARS microscopy and molecular imaging to reveal details of just how paclitaxel is released from from the polymer blends and why different compositions are better than others. Their results could help refine the formulation of the stent coating and ultimately improve success rates.

You can read more about their work in the Raman channel on SpectroscopyNOW.com

InChI=1/C47H51NO14/c1-25-31(60-43(56)36(52)35(28-16-10-7-11-17-28)48-41(54)29-18-12-8-13-19-29)23-47(57)40(61-42(55)30-20-14-9-15-21-30)38-45(6,32(51)22-33-46(38,24-58-33)62-27(3)50)39(53)37(59-26(2)4 9)34(25)44(47,4)5/h7-21,31-33,35-38,40,51-52,57H,22-24H2,1-6H3,(H,48,54)/t31-,32-,33+,35-,36+,37-,38-,40-,45+,46-,47+/m0/s1/f/h48H

Weirdly this page shows up in the search engines for the phrase “used cars” or used cars, or even used cars, I guess it’s not quite that odd, but it never occurred to me that it wouldn’t only show up for searches on those using coherent anti-Stokes Raman scattering microscopy (those who used CARS microscopy, in other words).

2 Responses to “Cars Constriction”

[...] David Bradley blogged on Spinneret about the application of coherent anti-Stokes Raman scattering microscopy to evaluate a new [...]

Taxol is a great example of a complex structure with lots of stereochemistry and a challenging enough example that there is a significant opportunity for misrepresentation – one stereocenter wrong and you don’t have THE Taxol anymore. It’s a great example for us to test the quality of data on the ChemSPider database (and others). I blogged about it here (http://www.chemspider.com/blog/?p=64)