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Epothilone B IxempraOne of the very first articles I wrote for Elemental Discoveries (Issue 3 in March 1997, it was) was on the subject of a novel class of anticancer compound that had been isolated from soil bacteria. The article (archived now on Sciencebase) discussed the discovery of a total synthesis for the archetypal epothilone.

Well, more than a decade since, and two decades after their initial discovery, the epothilones are about to enter the pharmaceutical market. More on anticancer epothilones here.

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