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Efficient synthesis of 2-nitroimidazole derivatives and the bioreductive clinical candidate Evofosfamide (TH-302) . Liam J. O'Connor, Cindy Cazares-Körner, Jaideep Saha, Charles N. G. Evans, Michael R. L. Stratford, Ester M. Hammond, Stuart J. Conway
, Org. Chem. Front.
, 2015
, 2
, 1026
Quantifying the effects of quadrupolar sinks via
15 N relaxation dynamics in metronidazoles hyperpolarized via SABRE-SHEATH . Jonathan R. Birchall, Mohammad S. H. Kabir, Oleg G. Salnikov, Nikita V. Chukanov, Alexandra Svyatova, Kirill V. Kovtunov, Igor V. Koptyug, Juri G. Gelovani, Boyd M. Goodson, Wellington Pham, Eduard Y. Chekmenev
, Chem. Commun.
, 2020
, 56
, 9098
Selective turn-on near-infrared fluorescence probe for hypoxic tumor cell imaging . Chen Jin, Qiumeng Zhang, Wei Lu
, RSC Adv.
, 2017
, 7
, 18217
Hypoxia-targeted drug delivery . Amit Sharma, Jonathan F. Arambula, Seyoung Koo, Rajesh Kumar, Hardev Singh, Jonathan L. Sessler, Jong Seung Kim
, Chem. Soc. Rev.
, 2019
, 48
, 771
Hypoxic tumor therapy based on free radicals . Jingtao Zheng, Yanyan Pan, Yubin Chen, Junyan Li, Weishuo Li
, Mater. Chem. Front.
, 2023
, 7
, 3576
Prodrugs as empowering tools in drug discovery and development: recent strategic applications of drug delivery solutions to mitigate challenges associated with lead compounds and drug candidates . Murugaiah A. M. Subbaiah, Jarkko Rautio, Nicholas A. Meanwell
, Chem. Soc. Rev.
, 2024
, 53
, 2099
Bioreductive fluorescent imaging agents: applications to tumour hypoxia . Robert B. P. Elmes
, Chem. Commun.
, 2016
, 52
, 8935
Synthesis and biological evaluation of benzocyclooctene-based and indene-based anticancer agents that function as inhibitors of tubulin polymerization . Christine A. Herdman, Tracy E. Strecker, Rajendra P. Tanpure, Zhi Chen, Alex Winters, Jeni Gerberich, Li Liu, Ernest Hamel, Ralph P. Mason, David J. Chaplin, Mary Lynn Trawick, Kevin G. Pinney
, Med. Chem. Commun.
, 2016
, 7
, 2418
The diverse pharmacology and medicinal chemistry of phosphoramidates – a review . Fabrício M. Oliveira, Luiz C. A. Barbosa, Fyaz M. D. Ismail
, RSC Adv.
, 2014
, 4
, 18998
Development of a cobalt(iii )-based ponatinib prodrug system . Marlene Mathuber, Michael Gutmann, Mery La Franca, Petra Vician, Anna Laemmerer, Patrick Moser, Bernhard K. Keppler, Walter Berger, Christian R. Kowol
, Inorg. Chem. Front.
, 2021
, 8
, 2468