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- Tumor regression and potentiation of polymeric vascular disrupting therapy through reprogramming of a hypoxia microenvironment with temsirolimus. Haiyang Yu, Na Shen, Yanli Bao, Li Chen, Zhaohui Tang
, Biomater. Sci.
, 2020
, 8
, 325
- Structure guided design of improved anti-proliferative rapalogs through biosynthetic medicinal chemistry. Matthew A. Gregory, Andrew L. Kaja, Steven G. Kendrew, Nigel J. Coates, Tony Warneck, Mohammad Nur-e-Alam, Rachel E. Lill, Lesley S. Sheehan, Lindsey Chudley, Steven J. Moss, Rose M. Sheridan, Miguel Quimpere, Ming-Qiang Zhang, Christine J. Martin, Barrie Wilkinson
, Chem. Sci.
, 2013
, 4
, 1046
- Natural products to drugs: natural product-derived compounds in clinical trials. Mark S. Butler
, Nat. Prod. Rep.
, 2008
, 25
, 475
- Synthesis and biological evaluation of rapamycin-derived, next generation small molecules. Shiva Krishna Reddy Guduru, Prabhat Arya
, Med. Chem. Commun.
, 2018
, 9
, 27
- A biomaterial screening approach reveals microenvironmental mechanisms of drug resistance. Alyssa D. Schwartz, Lauren E. Barney, Lauren E. Jansen, Thuy V. Nguyen, Christopher L. Hall, Aaron S. Meyer, Shelly R. Peyton
, Integr. Biol.
, 2017
, 9
, 912
- Genetically encoded biosensors for the detection of rapamycin: toward the screening of agonists and antagonists. Euiyeon Lee, Hyunjin Jeon, Jeahee Ryu, Chungwon Kang, Soyoun Kim, Seungil Park, Youngeun Kwon
, Analyst
, 2020
, 145
, 5571
- Biosynthetic medicinal chemistry of natural product drugs. Frank E. Koehn
, Med. Chem. Commun.
, 2012
, 3
, 854
- The allosteric mechanism of mTOR activation can inform bitopic inhibitor optimization. Yonglan Liu, Mingzhen Zhang, Hyunbum Jang, Ruth Nussinov
, Chem. Sci.
, 2024
, 15
, 1003
- Hypoxia inducible factor down-regulation, cancer and cancer stem cells (CSCs): ongoing success stories. Anthony R. Martin, Cyril Ronco, Luc Demange, Rachid Benhida
, Med. Chem. Commun.
, 2017
, 8
, 21
- Industrial natural product chemistry for drug discovery and development. Armin Bauer, Mark Brönstrup
, Nat. Prod. Rep.
, 2014
, 31
, 35